Molecular characteristic of Community-Acquired methicillin-resistant Staphylococcus aureus isolates by using New Genetic Diagnosis
| Project/Area Number |
21591294
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | MRSA / 分子疫学解析 / 薬剤耐性菌 / 病原因子 / 遺伝子診断 |
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| Research Abstract |
This study is a nationwide survey of all clinical methicillin-resistant Staphylococcus aureus(MRSA) isolates, including community-acquired MRSA(CA-MRSA), in Japan. Only 4(2. 3%) of 171 SCCmec type IV strains were Panton-Valentine leukocidin(lukS/ F-PV)-positive. Thus, this result indicates a unique feature of SCCmec type IV strains in Japan. The information in this study not only is important in terms of local public health but will also contribute to an understanding of epidemic clones of CA-MRSA
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Antimicrobial susceptibility and molecular characteristic of 857 methicillin-resistant Staphylococcus aureus isolates from 16 medical centers in Japan(2008-2009): Nationwide survey of community-acquired and nosocomial MRSA2012
Author(s)
Yanagihara K, Araki N, Watanabe S, Kinebuchi T, Kaku M, Maesakii S, Yamaguchi K, Matsumoto, Mikamo H, Takesue Y, Fujita J, Kadota J, Iwatsuki K, Hino H, Kaneko T, Asagoe K, Ikeda M, T Yasuoka A, Kohno S
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Journal Title
Diagn Microbiol Infect Dis
Volume: 72
Pages: 253-257
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[Journal Article] Clinical characteristics of bacteremia caused by methicillin-resistant Staphylococcus aureus in a tertiary hospital2011
Author(s)
Yamada K, Yanagihara K, Hara Y, Araki N, Harada Y, Morinaga Y, Matsuda J, Izumikawa K, Seki M, Kakeya H, Yamamoto Y, Kohno S, Kamihira S
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Journal Title
Tohoku J Exp Med
Volume: 224
Pages: 61-67
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[Journal Article] High dose tobramycin inhibits lipopolysaccharide-induced MUC5AC production in human lung epithelial cells2011
Author(s)
Nakamura S, Yanagihara K, Araki N, Morinaga Y, Yamada, K, Izumikawa K, Seki M, Kakeya H, Yamamoto Y, Kamihira S, Kohno
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Journal Title
European Journal of Pharmacology
Volume: 659
Pages: 67-71
NAID
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[Journal Article] Evaluation of pathogen detection from clinical samples by real-time polymerase chain reaction using a sepsis pathogen DNA detection Kit2010
Author(s)
Yanagihara K, Kitagawa Y, Tomonaga M, Tsukasaki K, Kohno S, Seki M, Sugimoto H, Shimazu T, Tasaki O, Matsushima A, Ikeda Y, Okamoto S, Aikawa N, Hori S, Obara H, Ishizaka A, Hasegawa N, Takeda J, Kamihira S, Sugahara K, Asari S, Murata M, Kobayashi Y, Gin
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Journal Title
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[Journal Article] Efficacy of linezolid against PVL-positive MRSA in a mouse model of hematogenous pulmonary infection2009
Author(s)
Yanagihara K, Kihara R, Araki N, Morinaga Y, Seki M, Izumikawa K, Kakeya H, Yamamoto Y, Yamada Y, Kamihira S, Tsukamoto K, Kohno S
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Journal Title
Int J Antimicrob Agents
Volume: 34
Pages: 477-481
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