Establishment of immuno-monitoring system for the infectious disease control and analysis of neutrophil dysfunction in various compromised hosts
| Project/Area Number |
21591300
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Teikyo University |
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Principal Investigator |
ONO Yasuo 帝京大学, 医学部, 教授 (10177272)
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| Co-Investigator(Kenkyū-buntansha) |
UBAGAI Tsuneyuki 帝京大学, 医学部, 講師 (10311416)
TANSHO Shigeru 帝京大学, 医学部, 助教 (50266300)
UEDA Takane 帝京大学, 医学部, 助教 (80459312)
KOSHIO Osamu 帝京大学, 医学部, 講師 (30365986)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 感染症防御学 / 易感染性 / 好中球 / セプシス / 遊走能 / 細胞膜抗原 / 遺伝子発現 / 活性酸素産生能 / 易感染性宿主 / TLR / 細胞内遺伝子発現 / HL-60 / CXCR1遺伝子導入 / 活性酸素 / 細胞表面抗原 / MAPK / 基準値 |
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| Research Abstract |
Neutrophil chemotaxis was reduced in septic patients and poorly controlled diabetic patients. Neutrophil bactericidal ability in the patients with liver cirrhosis, SLE, AIDS, myeloma, severe burn and elderly persons was significantly lower than that of healthy controls. Expression levels of neutrophil membrane antigens, CD14 and TLR-4 were higher in patients with sepsis ; however, the expression levels of CD11b and CD16 were lower. The gene expression of TREM-1 in neutrophils associated with the severity of sepsis. Analysis of neutrophil functions using these assays may be available as the sensitive and reliable immuno-monitoring tools for determining the capacity of host defense against bacterial infections in compromised hosts.
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Report
(4 results)
Research Products
(11 results)
