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Establishment of immuno-monitoring system for the infectious disease control and analysis of neutrophil dysfunction in various compromised hosts

Research Project

Project/Area Number 21591300
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Infectious disease medicine
Research InstitutionTeikyo University

Principal Investigator

ONO Yasuo  帝京大学, 医学部, 教授 (10177272)

Co-Investigator(Kenkyū-buntansha) UBAGAI Tsuneyuki  帝京大学, 医学部, 講師 (10311416)
TANSHO Shigeru  帝京大学, 医学部, 助教 (50266300)
UEDA Takane  帝京大学, 医学部, 助教 (80459312)
KOSHIO Osamu  帝京大学, 医学部, 講師 (30365986)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords感染症防御学 / 易感染性 / 好中球 / セプシス / 遊走能 / 細胞膜抗原 / 遺伝子発現 / 活性酸素産生能 / 易感染性宿主 / TLR / 細胞内遺伝子発現 / HL-60 / CXCR1遺伝子導入 / 活性酸素 / 細胞表面抗原 / MAPK / 基準値
Research Abstract

Neutrophil chemotaxis was reduced in septic patients and poorly controlled diabetic patients. Neutrophil bactericidal ability in the patients with liver cirrhosis, SLE, AIDS, myeloma, severe burn and elderly persons was significantly lower than that of healthy controls. Expression levels of neutrophil membrane antigens, CD14 and TLR-4 were higher in patients with sepsis ; however, the expression levels of CD11b and CD16 were lower. The gene expression of TREM-1 in neutrophils associated with the severity of sepsis. Analysis of neutrophil functions using these assays may be available as the sensitive and reliable immuno-monitoring tools for determining the capacity of host defense against bacterial infections in compromised hosts.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (11 results)

All 2012 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (7 results)

  • [Journal Article] Enhancement of interleukin-8-induced chemotactic response and reactive oxygen species production in HL-60 cells expressing CXCR12012

    • Author(s)
      Kikuchi-Ueda T, Tansho S, Ono Y
    • Journal Title

      J Infect Chemother

      Volume: (in press)

    • NAID

      10030787020

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of membrane antigens on neutrophils from patients with sepsis2012

    • Author(s)
      Tansho-Nagakawa S, Ubagai T, Kikuchi-Ueda T, Koshio O, Koshibu Y, Kikuchi H, Ono Y
    • Journal Title

      J Infect Chemother

      Volume: 18 Issue: 5 Pages: 646

    • DOI

      10.1007/s10156-012-0386-7

    • NAID

      10031120720

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of TREM1 gene expression in circulating polymorphonuclear leukocytes and its inverse correlation with the severity of pathophysiological conditions of patients with acute bacterial infections2012

    • Author(s)
      Ubagai T, Tansho-Nagakawa S, Ikeki T, Ono Y
    • Journal Title

      Jap J Infect Dis

      Volume: (in press)

    • NAID

      130001931845

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CXCR1発現HL-60細胞におけるインターロイキン-8誘導走化性応答および活性酸素種産生の増強(Enhancement of interleukin-8-induced chemotactic response and reactive oxygen species production in HL-60 cells expressing CXCR1)2012

    • Author(s)
      Kikuchi-Ueda T, Tansho S, Ono Y
    • Journal Title

      J Infect Chemother

      Volume: 18 Issue: 3 Pages: 283

    • DOI

      10.1007/s10156-011-0321-3

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 細菌感染症患者の末梢血白血球における抗原認識に関わる細胞膜抗原の解析2011

    • Author(s)
      丹生茂, ほか
    • Organizer
      第85回日本感染症学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 細菌感染症患者の末梢好中球内で重症度に関連して発現変化する遺伝子に関する検討2011

    • Author(s)
      祖母井庸之, ほか
    • Organizer
      第85回日本感染症学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 真菌および細菌由来菌体成分の好中球MAPK familyリン酸化に対する影響2011

    • Author(s)
      越尾修, ほか
    • Organizer
      第85回日本感染症学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 会長シンポジウム[ヒト・微生物・薬剤関係からみた感染症、最近の知見]1.宿主(ヒト)からみた感染症2010

    • Author(s)
      斧康雄
    • Organizer
      第84回日本感染症学会総会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2010-04-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 会長シンポジウム,「ヒト・微生物・薬剤関係からみた感染症,最新の知見」,宿主からみた感染症2010

    • Author(s)
      斧康雄
    • Organizer
      第84回日本感染症学会総会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] 原虫感染に対するHL-60を用いた好中球機能の解析,第2報2010

    • Author(s)
      上田たかね, ほか
    • Organizer
      第84回日本感染症学会総会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] 教育講演1 好中球からみたセプシス2009

    • Author(s)
      斧康雄
    • Organizer
      日本感染症学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2009-04-23
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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