Analysis of phosphate metabolism and treatment for hereditary hypophosphatemic rickets

Research Project

Project/Area Number	21591308
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Pediatrics
Research Institution	Tohoku University
Principal Investigator	FUJIWARA Ikuma 東北大学, 大学院・医学系研究科, 准教授 (10271909)
Co-Investigator(Kenkyū-buntansha)	HAKODA Akiko 東北大学, 病院, 医員 (70509398) KANNO Junko 東北大学, 病院, 医員 (30509386)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	低リン血性くる病 / FGF23 / DMP1 / 骨代謝 / リン調節機構
Research Abstract	According to Prof JQ Feng at Baylor Univ., they have already done experiments that were exactly the same as we had planned. They crossed osteoblast-spesific DMP-1 transgenic mice (DMP1-Tg)and hyp mice, model mice of hypophosphatemic rickets, though hypophosphatemia was not improved in those DMP-1/hyp mice. We decided to do another approach of the research because it was meaningless to do the same experiments that they did, but we could not get substantial achievements currently.

Report

(4 results)