温度感受性に基づく代謝機能回復因子の網羅的探索と新規治療法の開発
| Project/Area Number |
21591318
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Gifu University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脂質代謝異常 / ペルオキシソーム / 代謝ネットワーク / 遺伝病 / 代謝機能回復因子 / 温度感受性 / 生活習慣病 / 対者ネットワーク |
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| Research Abstract |
To clarify the molecular mechanism of a temperature-sensitive(TS) phenotype in peroxisomal biogenesis disorders(PBD), we analyzed the change of gene expression in the fibroblasts from PBD patients at 37℃and 30℃, using micro array method. Several hypoxia inducible genes may be possible to associate with TS phenomenon, therefore, we continue further study at a condition of hypoxia. Furthermore, we demonstrated mice fed on high-fat diet(HFD) induced hepatic gene expression of peroxisomal metabolism, which may provide useful fundamental information to understand the role of the peroxisomal function in obesity and lifestyle-related diseases.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Clinical biochemical and molecular characterization of peroxisomal diseases in Arabs2011
Author(s)
Shaheen R, Al-Dirbashi OY, Al-Hassnan ZN, Al-Owain M, Makhsheed N, Basheeri F, Seidahmed MZ, Salih MAM, Faqih E, Zaidan H, Al-Sayed M, Rahbeeni Z, Al-Sheddi T, Hashem M, Kurdi W, Shimozawa N, Alkuraya FS
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Journal Title
Clin Genet
Volume: 79
Issue: 1
Pages: 60-70
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of novel SNPs of ABCD1, ABCD2, ABCD3, and ABCD4 genes in patients with X-linked adrenoleukodystrophy(ALD) based on comprehensive resequencing and association studies with ALD phenotypes2011
Author(s)
Matsukawa T, Asheuer M, Takahashi Y, Goto J, Suzuki Y, Shimozawa N, Takano H, Onodera O, Nishizawa M, Aubourg P, Tsuji S
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Journal Title
Neurogenetics
Volume: 12
Issue: 1
Pages: 41-50
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical aspects and adrenal functions in eleven Japanese children with X-linked adrenoleukodystrophy2010
Author(s)
Miyoshi Y, Sakai N, Hamada Y, Tachibana M, Hasegawa Y, Kiyohara Y, Yamada H, Murakami M, Kondou H, Kimura-Ohba S, Mine J, Sato T, Kamio N, Ueda H, Suzuki Y, Shiomi M, Ohta H, Shimozawa N, Ozono K
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Journal Title
Endocrine Journal
Volume: 57
Issue: 11
Pages: 965-972
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed
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