| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
To clarify the molecular mechanism of a temperature-sensitive(TS) phenotype in peroxisomal biogenesis disorders(PBD), we analyzed the change of gene expression in the fibroblasts from PBD patients at 37℃and 30℃, using micro array method. Several hypoxia inducible genes may be possible to associate with TS phenomenon, therefore, we continue further study at a condition of hypoxia. Furthermore, we demonstrated mice fed on high-fat diet(HFD) induced hepatic gene expression of peroxisomal metabolism, which may provide useful fundamental information to understand the role of the peroxisomal function in obesity and lifestyle-related diseases.
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