| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Serum FGF23 levels were lower than 20 pg/ ml and higher than 40 pg/ ml in 21 patients with vitamin D-deficiency and with hypophosphatemic rickets, respectively.
Umbilical blood FGF23 levels were lower than those in normal adults and pregnant woman. On the other hand, umbilical blood soluble klotho levels were higher than those in normal adults and pregnant woman.
Serum FGF23 levels were high in affected fetus of hyp mice, while serum phosphate levels remained in normal range in affected fetus.
Chondrocyte transduced the signal of FGF23 when FGF23 and soluble klotho were given.
Intravenous administration of bisphosphonate rapidly lowered FGF23 levels in patients with osteogenesis imperfecta.
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