| Project/Area Number |
21591324
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Tottori University |
|---|
Principal Investigator |
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|---|
| Co-Investigator(Renkei-kenkyūsha) |
NAGATA Ikuo 鳥取大学, 医学部, 准教授 (50252846)
HANAKI Keiichi 鳥取大学, 医学部, 教授 (20238041)
KAWASHIMA Yuki 鳥取大学, 医学部附属病院, 助教 (20403412)
OKADA Shin-ichi 鳥取大学, 医学部, 講師 (50343281)
NAGAISHI Jun-ichi 鳥取大学, 医学部附属病院, 講師 (90346354)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 小児内分泌学 / IGF受容体 / 低身長 / インスリン様成長因子 / IGF-I不応症 / インスリン受容体 / インスリン受容体異常症 / 胎内発育遅延 |
|---|
| Research Abstract |
We identified heterozygous mutation(Asp1105Glu) of the IGF-IR gene in a Japanese girl with high serum IGF-I levels and with SGA short stature and her mother. Cells transfected with mutated IGF-IR gene did not show any autophosphorylation of IGF-IR in response to IGF-I. Co-transfection of mutated IGF-IR gene and wild-type IGF-IR gene resulted in dominant negative effects on autophosphorylation of wild-type IGF-IR.
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