Pathogenesis and pathophysiology of pediatric multiple sclerosis and acute disseminated encephalomyelitis

• Project/Area Number: 21591326
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kyushu University
• Principal Investigator: KIRA Ryutaro 九州大学, 大学病院, 特別教員 (70304805)
• Co-Investigator(Kenkyū-buntansha): TORISU Hiroyuki 九州大学, 大学病院, 助教 (10398076) ; SANEFUJI Masafumi 九州大学, 大学病院, 助教 (50467940) ; ISHIZAKI Yoshito 九州大学, 大学病院, 助教 (20572944) ; LEE Sooyoung 九州大学, 大学病院, 助教 (10529796)
• Co-Investigator(Renkei-kenkyūsha): MIZUGUCHI Masashi 東京大学, 医学系研究科, 教授 (20209753) ; ICHIYAMA Takashi 山口大学, 医学系研究科, 教授 (20263767) ; MAEGAKI Yoshihiro 鳥取大学, 医学部, 准教授 (80252849)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 小児神経学 / 急性散在性脳脊髄炎 / 多発性硬化症 / 小児 / 診断 / マーカー / 病因 / 病態

Research Abstract

Acute disseminate encephalomyelitis(ADEM) and pediatricmultiple sclerosis(MS) are very rare diseases. The pathogenesis and pathophysiology remain to be fully clarified. To find their diagnostic markers, we delineated the clinical features of the epidemiological backgrounds ; signs and symptoms ; laboratory, neurophysiological, and magnetic resonance imaging(MRI) findings ; treatments ; and prognoses of these diseases, based on the definition proposed by the International Pediatric MS Study Group(2007). In addition, we performed genetic association studies in ADEM patients and controls. The results revealed several characteristics of each disease.

Research Products

• [Journal Article] Clinical and MRI characteristics of acute encephalopathy in congenital adrenal hyperplasia (2011)
  • Author(s): Lee S, Sanefuji, M, Watanabe K, Uematsu A, Torisu, H, Baba H, Kira, R, Takada Y, Ishizaki Y, Toyoshima M, Aragaki F, Hata D, Hara T
  • Journal Title: J Neurol Sci Volume: 306 Issue: 1-2 Pages: 91-93
  • DOI: 10.1016/j.jns.2011.03.037
  • NAID: 120005133038
  • Peer Reviewed
• [Journal Article] Strategy in short葉erm memory for pictures in childhood (2011)
  • Author(s): Sanefuji, M, Takada Y, Kimura N, Torisu, H, Kira, R, Ishizaki Y, Hara T
  • Journal Title: a near擁nfrared spectroscopy study Volume: 54 Issue: 3 Pages: 2394-2400
  • DOI: 10.1016/j.neuroimage.2010.09.090
  • Peer Reviewed
• [Journal Article] Parental age and child growth and development (2011)
  • Author(s): Iwayama M, Kira, R, Kinukawa N, Sakai Y, Torisu, H, Sanefuji, M, Ishizaki Y, Nose Y, Matsumoto T, Hara T
  • Journal Title: child health check蓉p data Volume: 53 Issue: 5 Pages: 709-714
  • DOI: 10.1111/j.1442-200x.2011.03331.x
  • Peer Reviewed
• [Journal Article] 全面改訂版必携!けいれん、意識障害その時どうする (2011)
  • Author(s): 鳥巣浩幸
  • Journal Title: けいれん・意識障害を起こす疾患の治療管理のポイント多発性硬化症 Volume: 43 Pages: 538-540
• [Journal Article] Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis, and acute transverse myelitis in FukuokaPrefecture (2010)
  • Author(s): Torisu H, Kira R, Ishizaki Y, Sanefuji M, Yamaguchi Y, Yasumoto S, Murakami Y, Shimono M, Nagamitsu S, Masuzaki M, Amamoto M, Kondo R, Uozumi T, Aibe M, Gondo K, Hanai T, Hirose S, Matsuishi T, Shirahata A, Mitsudome A, Hara T.
  • Journal Title: Japan. Brain Dev Volume: 32(6) Issue: 6 Pages: 454-62
  • DOI: 10.1016/j.braindev.2009.10.006
  • Peer Reviewed
• [Journal Article] Genetic susceptibility to febrile seizures (2010)
  • Author(s): Kira, R, Ishizaki Y, Torisu, H, Sanefu j i, M, Takemoto M, Sakamoto K, Matsumoto S, Yamaguchi Y, Yukaya N, Sakai Y, Gondo K, Hara T
  • Journal Title: Case幼ontrol association studies Volume: 32 Issue: 1 Pages: 57-63
  • DOI: 10.1016/j.braindev.2009.09.018
• [Journal Article] PDl as a common candidate susceptibility gene of subacute sclerosing panencephalitis (2010)
  • Author(s): Ishizaki Y, Yukaya N, Kusuhara K, Kira, R, Torisu, H, Ihara K, Sakai Y, Sanefuji, M, Pipo-Deveza JR, Silao CL, Sanchez BC, Lukban MB, Salonga AM, Hara T
  • Journal Title: Hum Genet Volume: 127 Pages: 411-9
• [Journal Article] 我が国における小児急性散在性脳脊髄炎、多発性硬化症の現状 (2010)
  • Author(s): 山口結, 吉良龍太郎, 原寿郎
  • Journal Title: 脳と発達 Volume: 42(3) Pages: 227-229
  • NAID: 10026412282
• [Journal Article] 小児の治療指針 (2010)
  • Author(s): 吉良龍太郎
  • Journal Title: 急性散在性脳脊髄炎・多発性硬化症 Pages: 733-736
• [Journal Article] 必携小児の薬の使い方 (2010)
  • Author(s): 吉良龍太郎
  • Journal Title: 多発性硬化症 Volume: 42 Pages: 513-516
• [Journal Article] ここまでわかっている自己抗体と自己免疫疾患 (2010)
  • Author(s): 吉良龍太郎
  • Journal Title: 多発性硬化症・急性散在性脳脊髄炎 Volume: 73 Pages: 2135-8
• [Journal Article] Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis and acute transverse myelitis in Fukuoka Prefecture, Japan. (2010)
  • Author(s): Torisu H, Kira R, et al.
  • Journal Title: Brain Dev Volume: 32 Pages: 454-462
  • NAID: 10027491651
  • Peer Reviewed
• [Journal Article] Genetic susceptibility to febrile seizures : Case-control association studies. (2010)
  • Author(s): Kira R, et al.
  • Journal Title: Brain Dev Volume: 32 Pages: 57-63
  • NAID: 10027212465
  • Peer Reviewed
• [Journal Article] Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis and acute transverse myelitis in Fukuoka Prefecture, Japan (2010)
  • Author(s): Torisu H, et al
  • Journal Title: Brain Dev 32(In press)
  • NAID: 10027491651
  • Peer Reviewed
• [Journal Article] 免疫性神経疾患一新たな治療戦略に向けて
  • Author(s): 吉良龍太郎
  • Journal Title: 急性散在性脳脊髄炎の臨床と病理
• [Journal Article] PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis.
  • Author(s): Ishizaki, et al.
  • Journal Title: Hum Genet Volume: (In press)
  • Peer Reviewed
• [Presentation] 小児免疫性中枢神経疾患の臨床-最近の進歩-;小児多発性硬化症 (2011)
  • Author(s): 吉良龍太郎
  • Organizer: 第53回日本小児神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-05-26
• [Presentation] 小児免疫性中枢神経疾患の臨床一最近の進歩一小児多発性硬化症 (2011)
  • Author(s): 吉良龍太郎
  • Organizer: 第53回日本小児神経学会総会
  • Place of Presentation: 横浜
• [Presentation] 小児免疫性中枢神経疾患の臨床-景近の進歩-;小児急性散在性脳脊髄炎の臨床像 (2011)
  • Author(s): 鳥巣浩幸
  • Organizer: 第53回日本小児神経学会総会
  • Place of Presentation: 横浜
• [Presentation] Clinically isolated syndromeの臨床像?全国疫学調査より (2010)
  • Author(s): 鳥巣浩幸
  • Organizer: 第52回日本小児神経学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-05-21
• [Presentation] 多発性硬化症治療ガイドライン2010の概要と小児への応用 (2010)
  • Author(s): 吉良龍太郎
  • Organizer: 第52回日本小児神経学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-05-21
• [Presentation] 多発性硬化症治療ガイドライン2010の概要と小児への応用 (2010)
  • Author(s): 吉良龍太郎
  • Organizer: 第52回日本小児神経学会総会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2010-05-20
• [Presentation] 小児神経免疫疾患研究グループ:我が国における小児急性散在性脳脊髄炎、多発性硬化症の現状について:疾患定義案の概要 (2009)
  • Author(s): 吉良龍太郎,山口結,原寿郎
  • Organizer: 第51回日本小児神経学会総会
  • Place of Presentation: 米子
• [Presentation] 「我が国における小児急性散在性脳脊髄炎、多発性硬化症の現状について」;疾患定義案の概要 (2009)
  • Author(s): 吉良龍太郎, 他
  • Organizer: 第51回日本小児神経学会総会
  • Place of Presentation: 米子
• [Book] 急性散在性脳脊髄炎今日の小児治療指針第15版 (2012)
  • Author(s): 吉良龍太郎
  • Publisher: 医学書院
• [Book] 急性散在性脳脊髄炎P98-101『小児科臨床ピクシス』急性脳炎・急性脳症 (2011)
  • Author(s): 吉良龍太郎
  • Publisher: 中山書店
• [Book] 『小児科臨床ピクシス』(28)急性脳炎・急性脳症 (2011)
  • Author(s): 吉良龍太郎
  • Publisher: 中山書店
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/pediatr/msadem.htm
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/pediatr/msadem.htm
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/pediatr/msadem.htm