Molecular and behavioral analysis of transgenic mice of Angelman syndrome gene, Ube3a

Research Project

Project/Area Number	21591327
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Pediatrics
Research Institution	Nagasaki University
Principal Investigator	KISHINO Tatsuya 長崎大学, 先導生命科学研究支援センター, 准教授 (70315232)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords	UBE3A / アンジェルマン症候群 / トランスジェニックマウス / 神経細胞
Research Abstract	To address the role of UBE3A in brain development, we generated transgenic UBE3A mice expressing a full length UBE3A cDNA under control of the rat enolase 2, gamma, neuronal(Eno2) promoter. UBE3A-overexpressing transgenic mice showed normal phenotype. Neurobehavioral phenotypes in anxiety-related behaviors and social interactions of AS model mice were partially rescued by transgene expression in striatum neurons.

Report

(4 results)