Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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Research Abstract |
To address the role of UBE3A in brain development, we generated transgenic UBE3A mice expressing a full length UBE3A cDNA under control of the rat enolase 2, gamma, neuronal(Eno2) promoter. UBE3A-overexpressing transgenic mice showed normal phenotype. Neurobehavioral phenotypes in anxiety-related behaviors and social interactions of AS model mice were partially rescued by transgene expression in striatum neurons.
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