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EstablishingstrategytocontrolneonatalseizurefolIowingasphyxia

Research Project

Project/Area Number 21591339
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKurume University

Principal Investigator

IWATA Osuke  久留米大学, 医学部, 助教 (30465710)

Co-Investigator(Kenkyū-buntansha) IWATA Sachiko  久留米大学, 医学部, 助教 (40465711)
OKAMURA Hisayoshi  久留米大学, 高次脳疾患研究所, 助教 (00454918)
KANDA Hiroshi  久留米大学, 医学部, 助教 (30341340)
OKADA Junichiro  久留米大学, 医学部, 助教 (60389278)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords低酸素虚血 / γアミノ酪酸 / 新生児脳症 / Bumetanide / 新生児けいれん様発作 / 動物モデル / 神経興奮
Research Abstract

Newborn infants are vulnerable for seizures, which are generally resistant to anti-convulsants. In our current project, we developed a large animal model of neonatal seizure by titrating the depth of hypo-ventilation insult. To assess the seizure burden following the recovery from the insult, we developed a handy telemetry video EEG system with off-line amplitude-integrated EEG exchanger software, which enabled us to quantitate the frequency and the duration of seizures. Our model would be relevant to the clinical neonatal seizures following perinatal hypoxia-ischaemia, which could be used to assess the impact of the treatment on histopathological changes in the brain as well as to develop new pharmacological treatments.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (47 results)

All 2012 2011 2010 2009

All Journal Article (26 results) (of which Peer Reviewed: 14 results) Presentation (18 results) Book (3 results)

  • [Journal Article] Qualitative Brain MRI at Term and Cognitive Outcomes at 9 Years After Very Preterm Birth2012

    • Author(s)
      Iwata S, Nakamura T, Hizume E, Kihara H, Takashima S, Matsuishi T, and Iwata O.
    • Journal Title

      Pediatrics

      Volume: 129(5)

    • Related Report
      2011 Final Research Report
  • [Journal Article] Hypothermia for neonatal encephalopathy : Nationwide Survey of Clinical Practice in Japan as of August 20102012

    • Author(s)
      Iwata O, Nabetani M, Takenouchi T, Iwaibara T, Iwata S, Tamura M.
    • Journal Title

      Acta Paediatr

      Volume: 101(5)

    • Related Report
      2011 Final Research Report
  • [Journal Article] Sleep architecture in healthy 5-year-old preschool children : associations between sleep schedule and quality variables2012

    • Author(s)
      Iwata S, Iwata O, Iemura A, Iwasaki M, Matsuishi T.
    • Journal Title

      Acta Paediatr

      Volume: 101(3)

    • Related Report
      2011 Final Research Report
  • [Journal Article] Therapeutic hypothermia for neonatal encephalopathy : JSPNM & MHLW Japan Working Group Practice Guidelines Consensus Statement from the Working Group on Therapeutic Hypothermia for Neonatal Encephalopathy, Ministry of Health, Labor and Welfare(MHLW)2012

    • Author(s)
      Takenouchi T, Iwata O, Nabetani M, . Tamura M.
    • Journal Title

      Brain Dev

      Volume: 34(2) Pages: 165-170

    • Related Report
      2011 Final Research Report
  • [Journal Article] Past, present and future of hypothermic neuroprotection for neonatal encephalopathy in Japan : time to say good-by to the old remedies2012

    • Author(s)
      Iwata O, Takenouchi T.
    • Journal Title

      Brain Dev

      Volume: 34(2) Pages: 163-164

    • NAID

      10031049929

    • Related Report
      2011 Final Research Report
  • [Journal Article] Past, present and future of hypothermic neuroprotection for neonatal encephalopathy in Japan : time to say good-by to the old remedies2012

    • Author(s)
      Iwata O, Takenouchi T
    • Journal Title

      Brain Dev

      Volume: 34(2) Pages: 163-4

    • NAID

      10031049929

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic hypothermia for neonatal encephalopathy : JSPNM & MHLW Japan Working Group Practice Guidelines Consensus Statement from the Working Group on Therapeutic Hypothermia for Neonatal Encephalopathy, Ministry of Health, Labor and Welfare (MHLW), Japan, and Jap an Society for Perinatal and Neonatal Medicine (JSPNM)2012

    • Author(s)
      Takenouchi T, Iwata O, Nabetani M, Tamura M
    • Journal Title

      Brain Dev

      Volume: 34(2) Pages: 165-70

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypothermia for neonatal encephalopathy : Nationwide Survey of Clinical Practice in Japan as of August 20102012

    • Author(s)
      Iwata O, Nabetani M, Takenouchi T, Iwaibara T, Iwata S, Tamura M
    • Journal Title

      Acta Paediatr

      Volume: 101(5) Issue: 5

    • DOI

      10.1111/j.1651-2227.2011.02562.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Qualitative brain MRI at term and cognitive outcomes at g years after very preterm birth2012

    • Author(s)
      Iwata S, Nakamura T, Hizume E, Kihara H, Takashima S, Matsuishi T, Iwata O
    • Journal Title

      Pediatrics

      Volume: 129(5)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Filling the evidence gap : how can we improve the outcome of neonatal encephalopathy in the next 10 years2011

    • Author(s)
      Iwata O, Iwata S.
    • Journal Title

      Brain Dev

      Volume: 33(3) Pages: 221-228

    • NAID

      10029560851

    • Related Report
      2011 Final Research Report
  • [Journal Article] Propofol protects against anandamide-induced injury in human umbilical vein endothelial cells2011

    • Author(s)
      Ito T, Mishima Y, Ito A, Kameyama N, Harada H, Iwata O, Watanabe S, Ushijima K. Kurume Med J.
    • Volume
      58(1)
    • Pages
      15-20
    • NAID

      130001444130

    • Related Report
      2011 Final Research Report
  • [Journal Article] Levothyroxine replacement therapy and refractory hypotension out of transitional period in preterm infants2011

    • Author(s)
      Okada J, Iwata S, Hirose A, Kanda H, Yoshino M, Maeno Y, Matsuishi T, Iwata O.
    • Journal Title

      Clin Endocrinol(Oxf)

      Volume: 74(3) Pages: 354-364

    • Related Report
      2011 Final Research Report
  • [Journal Article] Determinants of sleep patterns in healthy Japanese 5-year-old children2011

    • Author(s)
      Iwata S, Iwata O, Iemura A, Iwasaki M, Matsuishi T.
    • Journal Title

      Int J Dev Neurosci

      Volume: 29(1) Pages: 57-62

    • Related Report
      2011 Final Research Report
  • [Journal Article] Determinants of outcomes following acute child encephalopathy and encephalitis : pivotal effect of early and delayed cooling2011

    • Author(s)
      Kawano G, Iwata O, Iwata S, Kawano K, Obu K, Kuki I, Rinka H, Shiomi M, Yamanouchi H, Kakuma T, Takashima S, Matsuishi T.
    • Journal Title

      Research Network for Acute Encephalopathy in Childhood. Arch Dis Child

      Volume: 96(10) Pages: 936-941

    • Related Report
      2011 Final Research Report
  • [Journal Article] Propofol protects against anandamide-induced injury in human umbilical vein endothelial cells2011

    • Author(s)
      Ito T, Mishima Y, Ito A, Kameyama N, Harada H, Iwata O, Watanabe S, Ushijima K
    • Journal Title

      Kurume Med J

      Volume: 58(1) Pages: 15-20

    • NAID

      130001444130

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Determinants of outcomes following acute child encephalopathy and encephalitis : pivotal effect of early and delayed cooling2011

    • Author(s)
      Kawano G, Iwata O, Iwata S, Kawano K, Obu K, Kuki I, Rinka H, Shiomi M, Yamanouchi H, Kakuma T, Takashima S, Matsuishi T; Research Network for Acute Encephalopathy in Childhood
    • Journal Title

      Arch Dis Child

      Volume: 96(10) Pages: 936-41

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sleep architecture in healthy 5-year-old preschool children : associations between sleep schedule and quality variables2011

    • Author(s)
      Iwata S, Iwata O, …, Matsuishi T
    • Journal Title

      Acta Paediatr

      Volume: 101 Issue: 3

    • DOI

      10.1111/j.1651-2227.2011.02515.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Levothyroxine replacement therapy and refractory hypotension out of transitional period in preterm infants.2011

    • Author(s)
      Okada J, Iwata O, et al.
    • Journal Title

      Clin Endocrinol.

      Volume: 74(3) Pages: 354-364

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Filling the evidence gap : how can we improve the outcome of neonatal encephalopathy in the next 10 years?2011

    • Author(s)
      Iwata O, Iwata S.
    • Journal Title

      Brain Dev.

      Volume: 33(3) Pages: 221-228

    • NAID

      10029560851

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Subtle white matter injury is common in term-born infants with a wide range of risks2010

    • Author(s)
      Iwata S, Bainbridge A, Nakamura T, Tamura M, Takashima S, Matsuishi T, Iwata O.
    • Journal Title

      Int J Dev Neurosci

      Volume: 28(7) Pages: 573-580

    • Related Report
      2011 Final Research Report
  • [Journal Article] Utility of subjective sleep assessment tools for healthy preschool children : a comparative study between sleep logs, questionnaires, and actigraphy2010

    • Author(s)
      Iwasaki M, Iwata S, Iemura A, Yamashita N, Tomino Y, Anme T, Yamagata Z, Iwata O, Matsuishi T.
    • Journal Title

      J Epidemiol

      Volume: 20(2) Pages: 143-149

    • NAID

      10026251793

    • Related Report
      2011 Final Research Report
  • [Journal Article] Determinants of outcomes following acute child encephalopathy and encephalitis : pivotal effect of early and delayed cooling.2010

    • Author(s)
      Kawano G, Iwata S, et al.
    • Journal Title

      Arch Dis Child.

      Volume: (E-publication, E-publication)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Utility of subjective sleep assessment tools for healthy preschool children : a comparative study between sleep logs, questionnaires, and actigraphy.2010

    • Author(s)
      Iwasaki M, Iwata S, et al.
    • Journal Title

      J Epidemiol.

      Volume: 20(2) Pages: 143-149

    • NAID

      10026251793

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age and gender specific prevalence of HTLV-12009

    • Author(s)
      Eshima N, Iwata O, et al.
    • Journal Title

      J Clin Virol. 45(2)

      Pages: 135-8

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain-type natriuretic peptide at birth reflects foetal maturation and antenatal stress2009

    • Author(s)
      Kanbe T, Iwata O, et al.
    • Journal Title

      Acta Paediatr. 98(9)

      Pages: 1421-5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Utility of subjective sleep assessment tools for healthy preschool children : a comparative study between sleep logs, questionnaires, and actigraphy2009

    • Author(s)
      Iwasaki M, Iwata O, et al.
    • Journal Title

      J Epidemiol. 5;20(2)

      Pages: 143-9

    • NAID

      10026251793

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 世界と日本におけるBayley III検査2011

    • Author(s)
      岩田欧介
    • Organizer
      第2回Bayley研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-08-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] 低体温療法の実際Consensus 2010に基づいた新生児の低体温療法ワークショップ2011

    • Author(s)
      岩田欧介
    • Organizer
      第56回日本未熟児新生児学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 方向性拡散強調画像を用いた新生児脳の発達評価FA、ADCを用いた定量的検討2011

    • Author(s)
      大矢崇志, 岩田幸子, 才津宏樹, 海野光昭, 岡田純一郎, 神田洋, 前野泰樹, 岩田欧介, 松石豊次郎
    • Organizer
      第114回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] ハイリスク児の成長と脳の微細構造2011

    • Author(s)
      木下正啓, 田中祥一朗, 海野光昭, 才津宏樹, 岡田純一郎, 岩田幸子, 神田洋, 松石豊治郎, 前野泰樹, 岩田欧介
    • Organizer
      第47回日本周産期・新生児医学会総会および学術集会
    • Place of Presentation
      札幌
    • Related Report
      2011 Final Research Report
  • [Presentation] 小児における脳低温療法小児領域における脳低温療法現状とこれからの課題2011

    • Author(s)
      岩田欧介
    • Organizer
      第14回日本脳低温療法学会
    • Place of Presentation
      鹿児島
    • Related Report
      2011 Final Research Report
  • [Presentation] ベッドサイドにおける新生児の脳成熟度評価の試み2011

    • Author(s)
      大矢崇志, 岩田幸子, 永光信一郎, 山下裕史朗, 岩田欧介, 松石豊次郎
    • Organizer
      第53回日本小児神経学会総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 日本における新生児脳症に対する低体温療法の全国調査2011

    • Author(s)
      武内俊樹, 岩田欧介, 鍋谷まこと, 田村正徳
    • Organizer
      第53回日本小児神経学会総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 小児急性脳症・脳炎に対する脳低温療法の多施設共同研究に向けて2011

    • Author(s)
      河野剛, 岩田欧介, 武内俊樹, 山内秀雄, 松石豊次郎
    • Organizer
      第53回日本小児神経学会総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 混沌の海と航海新世代モニタリングは黄金の羅針盤となり得るか?2011

    • Author(s)
      岩田欧介
    • Organizer
      第14回日本脳低温療法学会教育講演
    • Place of Presentation
      鹿児島
    • Related Report
      2011 Annual Research Report
  • [Presentation] 小児における脳低温療法小児領域における脳低温療法現状とこれからの課題2011

    • Author(s)
      岩田欧介
    • Organizer
      第14回日本脳低温療法学会シンポジスト
    • Place of Presentation
      鹿児島
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新生児脳低温療法日本において新生児脳低温療法は標準的医療と成り得るか新生児の低体温療法標準治療普及への鍵2011

    • Author(s)
      岩田欧介
    • Organizer
      第47回日本周産期・新生児医学会総会および学術集会シンポジスト
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] 発達神経学を身近に…神経学と言う堅物を手なずけるには?2011

    • Author(s)
      岩田欧介
    • Organizer
      日本未熟児新生児学会第15回教育セミナー
    • Place of Presentation
      長野
    • Related Report
      2011 Annual Research Report
  • [Presentation] Bayley式乳幼児発達評価法第3版-総論1:検査の概略と日本・世界における未来Bayley式乳幼児発達評価第3版実践ワークショップ2011

    • Author(s)
      岩田欧介
    • Organizer
      第56回日本未熟児新生児学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hypothermic Neuroprotection for Encephalopathic Infants and Children in Japan : Past, Present and Future2011

    • Author(s)
      Osuke Iwata, Go Kawano, Toshiki Takenouchi, Makoto Nabetani, Sachiko Iwata, Ikuya Ueta, Masaki Shimizu, Satoshi Ibara, Masanori Tamura, Ken Nagao
    • Organizer
      The 4th International Hypothermia Symposium
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脳低温療法の未来日本と世界における脳低温療法の問題点と今後の課題について2010

    • Author(s)
      岩田欧介
    • Organizer
      日本未熟児新生児学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新生仔豚を用いた低酸素性虚血性脳症モデルでのキセノンガス吸入による脳保護の可能性2010

    • Author(s)
      加藤丈典, 岩田欧介, 岩田幸子, 戸苅創
    • Organizer
      第52回日本小児神経学会総会
    • Place of Presentation
      福岡
    • Related Report
      2011 Final Research Report
  • [Presentation] Physiological Effects of 50% Xenon Inhaled Aloneor Combined with Therapeutic Hypothermia for 24 h in an Experimental Model of Perinatal Asphyxia2009

    • Author(s)
      Kato T, 他(10名中7番目)
    • Organizer
      Annual Meeting of Pediatric Academic Societies
    • Place of Presentation
      Baltimore
    • Related Report
      2011 Final Research Report
  • [Presentation] Amiloride Does Not Provide Significant Neuroprotection When Administered after Resuscitation in a Newborn Piglet Model of Perinatal Asphyxia2009

    • Author(s)
      Kapetanakis A他(9名中6番目)
    • Organizer
      Annual Meeting of Pediatric Academic Societies
    • Place of Presentation
      Baltimore
    • Related Report
      2011 Final Research Report
  • [Book] Consensus 2010に基づく新生児低体温療法実践マニュアル2011

    • Author(s)
      田村正徳, 岩田欧介, 岩田幸子, 鍋谷まこと, 武内俊樹
    • Publisher
      東京医学社
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Book] 新生児・小児のための脳低温療法-日本脳低温療法学会公認テキスト2011

    • Author(s)
      茨聡, 岩田欧介, 徳久琢也, 他
    • Publisher
      メディカ出版
    • Related Report
      2011 Final Research Report
  • [Book] 新生児・小児のための脳低温療法2011

    • Author(s)
      茨聡, 岩田欧介, 他
    • Total Pages
      150
    • Publisher
      メディカ出版
    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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