| Project/Area Number |
21591340
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yukiyo 産業医科大学, 医学部, 助教 (20279334)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 小児 / 栄養 / 肥満 / 生活習慣病 / 脂肪細胞 / 酸化ストレス / 小児肥満 / メタボリックシンドローム / 摂食 / 新生児 |
|---|
| Research Abstract |
I have studied by this research grant the association of prenatal adipocytokine levels with the postnatal growth, and the redox status in obese school-aged children. Postnatal development of Nesfatin-1, a new appetite regulator, gene expression has also been studied in rats. Furthermore, the production of NO, MCP-1, etc. have been studied in cultured adipocytes stimulated by TNF-alpha, and the effects of some drugs on these. I have planed further adult-disease model experiments. I have also presented the problems of the evaluation methods for obese children.
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