Production mechanisms and roles of antibodies to glutamate receptor in ac ute encephalitis.
| Project/Area Number |
21591342
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | 独立行政法人国立病院機構(静岡てんかん・神経医療センター) (2011)
National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders (2009-2010) |
|---|
Principal Investigator |
TAKAHASHI Yukitoshi 独立行政法人国立病院機構(静岡てんかん・神経医療センター), 臨床研究部, 部員(統括診療部長) (70262764)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NISHIMURA Shigeko 独立行政法人国立病院機構静岡てんかん・神経医療センター(臨床研究部), 臨床研究部, 室員 (60393120)
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|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Keywords | 急性脳炎 / 辺縁系脳炎 / 卵巣奇形腫 / GluRψ2(NR2B) / GluRζ1(NR1) / アポトーシス / サイトカイン / GluRε2(NR2B) / GluRε2 (NR2B) / GluRζ1 (NR1) |
|---|
| Research Abstract |
In CSF from patients with non-herpetic acute limbic encephalitis(NHALE), antibodies to GluRψ2(NR2B) and GluRζ1(NR1) we re related with clinical evolution. Antibodies to NMDAR seemed to internalize extra-synaptic NMDAR, because those antibod i es prevent ed apoptosis of rat cultured neurons. Those antibodies seemed not to inte rnalize synaptic NMDAR, because those did not affect phosphorylation of CREB(cAMP-Responsive-Element-Binding protein). These may contribute to the relatively better outcome of NHALE.
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Report
(4 results)
Research Products
(187 results)
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[Journal Article] CDKL5 alterations lead to early epileptic encephalopathy in both genders2011
Author(s)
Jao-Shwann Liang, Keiko Shimojima, Rumiko Takayama, Jun Natsume, MinobuShichiji, Kyoko Hirasawa, Kaoru Imai, Tohru Okanishi, Seiji Mizuno, Akihisa Okumura, Midori Sugawara, Tomoshiro Ito, Hiroko Ikeda, Yukitoshi Takahashi, Hirokazu Oguni, Katsumi Imai, Makiko Osawa, Toshiyuki Yamamoto
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Journal Title
Epilepsia
Volume: 52-10
Issue: 10
Pages: 1835-1842
DOI
Related Report
Peer Reviewed
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[Journal Article] Nationwide survey(incidence, clinical course, prognosis) of Rasmussen s encephalitis2010
Author(s)
Ayako Muto, Hirokazu Oguni, Yukitoshi Takahashi, Yukiyoshi Shirasaka, Yukio Sawaishi, Tamami Yano, Toru Hoshida, Hitoshi Osaka, Satoru Nakasu, Noriyuki Akasaka, Kenji Sugai, Akie Miyamoto, Satoru Takahashi, Motomasa Suzuki, Iori Ohmori, Shin Nabatame, Makiko Osawa
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Journal Title
Brain Dev
Volume: 32-6
Issue: 6
Pages: 445-53
DOI
Related Report
Peer Reviewed
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[Journal Article]2010
Author(s)
高橋幸利, 他
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Journal Title
Annual Review神経2010(中外医学社)
Pages: 85-93
Related Report
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