The function of LARG in the nucleus
| Project/Area Number |
21591348
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SUZUKI Nobuchika 東京大学, 先端科学技術研究センター, 特任助教 (90247007)
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| Co-Investigator(Kenkyū-buntansha) |
KOZASA Tohru 東京大学, 先端科学技術センター, 特任教授 (70202059)
KAWAMURA Takeshi 東京大学, 先端科学技術センター, 特任助教 (70306835)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 小児血液学 / 白血病細胞 / 分化 / RH-RhoGEF / G蛋白質 / ショットガンプロテオミクス / リン酸化 |
|---|
| Research Abstract |
The signal through p115RhoGEF in the nucleus, collaborating with the canonical Gα13~p115RhoGEF～RhoA pathway at the plasma membrane, may regulate the differentiation of HL60 cells.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] A method of generating antibodies against exogenously administered self-antigen by manipulating CD4+CD25+ regulatory T cells.2011
Author(s)
IWANARI, H., NAKADA-NAKURA, Y., KUSANO-ARAI, O., SUZUKI, N., KODAMA, T., SAKIHAMA, T. & HAMAKUBO, T.
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Journal Title
J Immunol Methods
Volume: 369
Pages: 108-14
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[Journal Article] Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface.2009
Author(s)
SUZUKI, N., TSUMOTO, K., HAJICEK, N., DAIGO, K., TOKITA, R., MINAMI, S., KODAMA, T., HAMAKUBO, T. & KOZASA, T.
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Journal Title
J Biol Chem
Volume: 284
Pages: 5000-9
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