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Study of innate immunity in primary antibody deficiency

Research Project

Project/Area Number 21591350
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionUniversity of Toyama

Principal Investigator

KANEGANE Hirokazu  富山大学, 大学病院, 講師 (00293324)

Co-Investigator(Renkei-kenkyūsha) ISHIKAWA Fumihiko  理化学研究所, 免疫アレルギー科学総合研究センター ヒト疾患モデル研究ユニット, ユニットリーダー (30403918)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords抗体産生不全症 / 自然免疫 / X連鎖無ガンマグロブリン血症 / Toll様受容体 / ブルトンチロシンキナーゼ
Research Abstract

Approximately 15-20% of patients with X-linked agammaglobulinemia(XLA), which is caused by BTK deficiency, have neutropenia, and it is associated with the severity of infection. BTK-deficient neutrophils had more production of reactive oxygen species(ROS) after various stimuli, which was associated with more apoptosis. The production of ROS and apoptosis of BTK-deficient neutrophils were reversed by transduction of recombinant BTK. These data suggest that severe neutropenia in patients with XLA can be treated with recombinant BTK.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (67 results)

All 2012 2011 2010 2009

All Journal Article (48 results) (of which Peer Reviewed: 46 results) Presentation (9 results) Book (10 results)

  • [Journal Article] Clinical and genetic characteristics of XIAP deficiency in Japan2012

    • Author(s)
      Yang X, Kanegane H, 他15名
    • Journal Title

      J Clin Immunol

      Volume: 32 Pages: 411-420

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Epstein-Barr virus(EBV)-infected cells in EBV-associated hemophagocytic lymphohistiocytosis in two patients with X-linked lymphoproliferative syndrome type 1 and type 22012

    • Author(s)
      Yang X, Kanegane H, 他11名(13番目)
    • Journal Title

      Herpesviridae

      Volume: 3 Pages: 1-1

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils2012

    • Author(s)
      Honda F, Kanegane H, 他7名(3番目)
    • Journal Title

      Nat Immunol

      Volume: 13 Pages: 36-378

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features and outcome of X-linked lymphoproliferative syndrome type 1(SAP deficiency) in Japan identified by the combination of flow cytometric assay and genetic analysis2012

    • Author(s)
      Kanegane H, 他7名
    • Journal Title

      Pediatr Allergy Immunol

      Volume: 21

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Delayed onset adenosine deaminase deficiency associated with acute disseminated encephalomyeliti2012

    • Author(s)
      Nakaoka H, Kanegane H, 他15名
    • Journal Title

      Int J Hematol

      Volume: 24

    • NAID

      10030793746

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Severe primary antibody deficiency due to a novel mutation of micro heavy chain2012

    • Author(s)
      Mohammadzadeh I, Kanegane H, 他10名(9番目)
    • Journal Title

      J Investig Allergol Clin Immunol

      Volume: 22 Pages: 78-79

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early and rapid detection of X-linked lymphoproliferative syndrome with SH2D1A mutations by flow cytometry2012

    • Author(s)
      Zhao M, Kanegane H, 他10名
    • Journal Title

      Cytometry B Clin Cytom

      Volume: 80 Pages: 8-13

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and genetic characteristics of XIAP deficiency in Japan2012

    • Author(s)
      Yang X, Kanegane H, et al
    • Journal Title

      J Clin Immunol

      Volume: 32(3)巻 Pages: 411-420

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Epstein-Barr virus (EBV)-infected cells in EBV-associated hemophagocytic lymphohistiocytosis in two patients with X-linked lymphoproliferative syndrome type 1 and type 22012

    • Author(s)
      Yang X, Kanegane H, et al
    • Journal Title

      Herpesviridae

      Volume: 3 Pages: 1-1

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils2012

    • Author(s)
      Honda F, Kanegane H, et al
    • Journal Title

      Nat Immunol

      Volume: 13 Issue: 4 Pages: 369-378

    • DOI

      10.1038/ni.2234

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency : a multicenter study on the manifestations, management, and outcome of the disease2011

    • Author(s)
      Booth C, Kanegane H, 他46名(39番目)
    • Journal Title

      Blood

      Volume: 117 Pages: 53-62

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] X-linked agammaglobulinemia complicated with endobronchial tuberculosis2011

    • Author(s)
      Kawakami C, Kanegane H, 他4名(4番目)
    • Journal Title

      Acta Paediatr

      Volume: 100 Pages: 466-468

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1(XLP-1/SAP-deficiency) versus type 2(XLP-2/XIAP-deficiency)2011

    • Author(s)
      Pachlopnik Schmid J, Kanegane H, 他31名(7番目)
    • Journal Title

      Blood

      Volume: 117 Pages: 1522-1529

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 幼児期に見逃されてしまったX連鎖無ガンマグロブリン血症の1例2011

    • Author(s)
      竹綱庸仁、金兼弘和、他8名(10番目)
    • Journal Title

      小児科臨床

      Volume: 64 Pages: 64-65

    • Related Report
      2011 Final Research Report
  • [Journal Article] Exonic deletion of CASP10 in a patient presenting with systemic juvenile idiopathic arthritis, but not with autoimmune lymphoproliferative syndrome type IIa2011

    • Author(s)
      Tadaki H, Kanegane H, 他14名(3番目)
    • Journal Title

      Int J Immunogenet

      Volume: 37 Pages: 287-293

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantification ofκ-deleting recombination excision circles in Guthrie cards for the identification of early B-cell maturation defects2011

    • Author(s)
      Nakagawa N, Kanegane H, 他22名(3番目)
    • Journal Title

      J Allergy Clin Immunol

      Volume: 128

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmune lymphoproliferative syndrome mimicking chronic active Epstein-Barr virus infection2011

    • Author(s)
      Nomura K, Kanegane H, 他5名
    • Journal Title

      Int J Hematol

      Volume: 93 Pages: 760-764

    • NAID

      10029535559

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analysis of contiguous X-chromosome deletion syndrome encompassing the BTK and TIMM8A genes2011

    • Author(s)
      Arai T, Kanegane H, 他8名(3番目)
    • Journal Title

      J Hum Genet

      Volume: 56 Pages: 577-582

    • NAID

      10030660427

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disseminated BCG Infection Mimicking Metastatic Nasopharyngeal Carcinoma in an Immunodeficient Child with a Novel Hypomorphic NEMO Mutation2011

    • Author(s)
      Imamura M, Kanegane H, 他13名(7番目)
    • Journal Title

      J Clin Immunol

      Volume: 31 Pages: 802-810

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of FOXP3-negative regulatory T-like(CD4^+CD25^+CD127^<low>) cells in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome2011

    • Author(s)
      Otsubo K, Kanegane H, 他15名、
    • Journal Title

      Clin Immunol

      Volume: 141 Pages: 111-120

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Atypical case of X-linked agammaglobulinemia diagnosed at 45 years of age2011

    • Author(s)
      Fujioka T, Kanegane H, 他6名(7番目)
    • Journal Title

      Pediatr Int

      Volume: 53 Pages: 611-612

    • NAID

      10029559433

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hematopoietic stem cell transplantation with reduced intensity conditioning from a familyhaploidentical donor in an infant with familial hemophagocytic lymphohistocytosis2011

    • Author(s)
      Ohta H, Kanegane H, 他12名(12番目)
    • Journal Title

      Int J Hematol

      Volume: 94 Pages: 285-290

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nationwide Survey of Patients with Primary Immunodeficiency Diseases in Japan2011

    • Author(s)
      Ishimura M, Kanegane H, 他13名(6番目)
    • Journal Title

      J Clin Immunol

      Volume: 31 Pages: 968-976

    • NAID

      120005133089

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early and rapid detection of X-linked lymphoproliferative syndrome with SH2D1A mutations by flow cytometry2011

    • Author(s)
      Zhao M, Kanegane H, et al
    • Journal Title

      Cytometry B Clin Cytom

      Volume: 80 Issue: 1 Pages: 8-13

    • DOI

      10.1002/cyto.b.20552

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP-deficiency) versus type 2 (XLP-2/XIAP-deficiency)2011

    • Author(s)
      Pachlopnik Schmid J, Kanegane H, et al
    • Journal Title

      Blood

      Volume: 117 Pages: 1522-1529

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 幼児期に見逃されてしまったX連鎖無ガンマグロブリン血症の1例2011

    • Author(s)
      竹綱庸仁、金兼弘和, ほか
    • Journal Title

      小児科臨床

      Volume: 64 Pages: 61-65

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
  • [Journal Article] Quantification of K-deleting recombination excision circles in Guthrie cards for the identification of early B-cell maturation defects2011

    • Author(s)
      Nakagawa N, Kanegane H, et al
    • Journal Title

      J Allergy Clin Immunol

      Volume: 128 Pages: 223-225

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmune lymphoproliferative syndrome mimicking chronic active Epstein-Barr virus infection2011

    • Author(s)
      Nomura K, Kanegane H, et al
    • Journal Title

      Int J Hematol

      Volume: 93 Pages: 760-4

    • NAID

      10029535559

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disseminated BCG infection mimicking metastatic nasopharyngeal carcinoma in an immunodeficient child with a novel hypomorphic NEMO mutation2011

    • Author(s)
      Imamura M, Kanegane H, et al
    • Journal Title

      J Clin Immunol

      Volume: 31 Pages: 802-810

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of FOXP3-negative regulatory T-like (CD4^+CD25^+CD127^<low>) cells in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome2011

    • Author(s)
      Otsubo K, Kanegane H, et al
    • Journal Title

      Clin Immunol

      Volume: 141 Pages: 111-120

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hematopoietic stem cell transplantation with reduced intensity conditioning from a family haploidentical donor in an infant with familial hemophagocytic lymphohistocytosis2011

    • Author(s)
      Ohta H, Kanegane H, et al
    • Journal Title

      Int J Hematol

      Volume: 94 Pages: 286-290

    • NAID

      10029694397

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early and rapid detection of X-linked lymphoproliferative syndrome with SH2D1A mutations by flow cytometry.2011

    • Author(s)
      Zhao M, Kanegane H, et al.
    • Journal Title

      Cytometry B Clin Cytom

      Volume: 80 Pages: 8-13

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency : a multicenter study on the manifestations, management, and outcome of the disease.2011

    • Author(s)
      Booth C, Kanegane H, et al.
    • Journal Title

      Blood

      Volume: 117 Pages: 53-62

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] X-linked agammaglobulinemia complicated with endobronchial tuberculosis.2011

    • Author(s)
      Kawakami C, Kanegane H, et al.
    • Journal Title

      Acta Paediatr

      Volume: 100 Pages: 466-468

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1(XLP-1/SAP-deficiency)versus type 2(XLP-2/XIAP-deficiencv).2011

    • Author(s)
      Pachlopnik Schmid J, Kanegane H, et al.
    • Journal Title

      Blood

      Volume: 117 Pages: 1522-1529

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel XIAP mutation in a Japanese boy with recurrent pancytopenia and splenomegaly.2010

    • Author(s)
      Zhao M, Kanegane H, et al.
    • Journal Title

      Haematogica

      Volume: 95 Pages: 688-689

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyper IgD and periodic fever syndrome in Japan.2010

    • Author(s)
      Kawashima Kanegane H, et al.
    • Journal Title

      J Tokyo Med Univ

      Volume: 68 Pages: 235-238

    • NAID

      10026237739

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IPEX症候群とヒトTreg細胞2010

    • Author(s)
      大坪慶輔、金兼弘和, ほか
    • Journal Title

      臨床免疫学会雑誌

      Volume: 33 Pages: 196-206

    • NAID

      130006949797

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation of the BTK gene and clinical feature of X-linked agammaglob ulinemia in Mainland China.2009

    • Author(s)
      Wang Y, Kanegane H, et al.
    • Journal Title

      J Clin Immunol 29

      Pages: 352-356

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Minimal change nephritic syndrome associated with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.2009

    • Author(s)
      Hashimura Y, Kanegane H, et al
    • Journal Title

      Pediatr Nephrol 24

      Pages: 1181-1186

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutropenia associated with X-linked agammaglobulinemia in an Iranian referral center.2009

    • Author(s)
      Aghamohammadi A, Kanegane H, et al.
    • Journal Title

      Iran J Allergy Asthma Immunol 8

      Pages: 43-47

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pneumocystis jiroveci pneumonia as an atypical presentation of X-linked agammaglobulinemia.2009

    • Author(s)
      Kanegane H, et al.
    • Journal Title

      Int J Hematol 89

      Pages: 716-717

    • NAID

      10025162231

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three brothers of X-linked agammaglobulinemia : the relation between phenotype and neutropenia.2009

    • Author(s)
      Kawakami C, Kanegane H, et al.
    • Journal Title

      Int J Hematol 90

      Pages: 117-119

    • NAID

      10025162704

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel immunoregulatory protein in human colostrum, syntenin-1, for promoting the development of IgA-producing cells from cord blood B cells.2009

    • Author(s)
      Shira MM, Kanegane H, et al.
    • Journal Title

      Int Immunol 21

      Pages: 1013-1023

    • NAID

      10027389170

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新生児における免疫機能とその発達2009

    • Author(s)
      金兼弘和
    • Journal Title

      日本産婦人科・新生児血液学会誌 18

      Pages: 155-164

    • NAID

      10026710069

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of severe combined immunodeficiency by T-cell receptor excision circles quantification using neonatal Guthrie cards2009

    • Author(s)
      Morinishi Y, Kanegane H, et al.
    • Journal Title

      J Pediatr 155

      Pages: 829-833

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemokine receptor expression and functional effects of chemokines on B cells : implication in the pathogenesis of rheumatoid arthritis.2009

    • Author(s)
      Nanki T, Kanegane H, et al.
    • Journal Title

      Arthritis Res Ther 11

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IPEX症候群と腎疾患2009

    • Author(s)
      橋村裕也、金兼弘和, ほか
    • Journal Title

      日本小児腎臓病学会雑誌 22

      Pages: 131-139

    • NAID

      10026411780

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 抗体産生不全症における臨床遺伝学2011

    • Author(s)
      金兼弘和
    • Organizer
      遺伝医学合同学術集会2011
    • Place of Presentation
      京都市(招待講演)
    • Year and Date
      2011-06-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] SAP and XIAP deficiency in hemophagocytic lymphohistiocytosis2011

    • Author(s)
      Kanegane H
    • Organizer
      The 3^<rd> Symposium for PID in Asia
    • Place of Presentation
      Denver、Colorado、USA
    • Year and Date
      2011-05-01
    • Related Report
      2011 Final Research Report
  • [Presentation] SAP and XIAP deficiency in hemophagocytic lymphohistiocytosis2011

    • Author(s)
      Kanegane H
    • Organizer
      The 3^<rd> Symposium for PID in Asia
    • Place of Presentation
      Denver, Colorado, USA(招待講演)
    • Year and Date
      2011-05-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 原発性免疫不全症における臨床遺伝学「抗体産生不全症における臨床遺伝学」2011

    • Author(s)
      金兼弘和
    • Organizer
      遺伝医学合同学術集会2011
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] 教育講演「腸管出血性大腸菌O111の集団発生から学んだこと」2011

    • Author(s)
      金兼弘和
    • Organizer
      第43回日本小児感染症学会
    • Place of Presentation
      岡山市.
    • Related Report
      2011 Final Research Report
  • [Presentation] Flow cytometric diagnosis of XLP1 and 22010

    • Author(s)
      Kanegane H
    • Organizer
      XLP symposium 2010
    • Place of Presentation
      London
    • Year and Date
      2010-02-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] T-B-NK+ Severe combined immunodeficiency caused by a common gamma chain deficiency.2010

    • Author(s)
      Kanegane H, et al.
    • Organizer
      First CIS North American Primary Immune Deficiency National Conference
    • Place of Presentation
      Philadelphia, U.S.A.
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification of FOXP3-negative regulatory T-like(CD127^<dim>CD25^+CD4^+)cells in patients with IPEX.2010

    • Author(s)
      Kanegane H, et al.
    • Organizer
      XIVth Meeting of the European Society for Immunodeficiencies(ESID)
    • Place of Presentation
      Istanbul, Turkey
    • Related Report
      2010 Annual Research Report
  • [Presentation] IPEX症候群とヒトTreg細胞2009

    • Author(s)
      金兼弘和
    • Organizer
      第37回日本臨床免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Book] 原発性免疫不全症、「今日の小児治療指針第15版」2012

    • Author(s)
      金兼弘和
    • Publisher
      医学書院
    • Related Report
      2011 Final Research Report
  • [Book] コロナウイルス、ブニアウイルス、JCウイルス、プリオン、「日常診療に役立つ小児感染症マニュアル2012」2012

    • Author(s)
      西田直徳、金兼弘和
    • Publisher
      東京医学社
    • Related Report
      2011 Final Research Report
  • [Book] 免疫調節障害、小児の発熱AtoZ2012

    • Author(s)
      金兼弘和
    • Publisher
      診断と治療社
    • Related Report
      2011 Final Research Report
  • [Book] 今日の小児治療指針第15版2012

    • Author(s)
      金兼弘和
    • Total Pages
      2
    • Publisher
      原発性免疫不全症
    • Related Report
      2011 Annual Research Report
  • [Book] 小児の発熱A to Z2012

    • Author(s)
      金兼弘和
    • Total Pages
      4
    • Publisher
      免疫調節障害
    • Related Report
      2011 Annual Research Report
  • [Book] 免疫不全関連リンパ増殖性疾患、小児がん診療ハンドブック~実地診療に役立つ診断・治療の理念と実践~2011

    • Author(s)
      金兼弘和、他
    • Publisher
      医薬ジャーナル社
    • Related Report
      2011 Final Research Report
  • [Book] 先天性免疫不全症、血液専門医テキスト2011

    • Author(s)
      金兼弘和
    • Publisher
      南江堂
    • Related Report
      2011 Final Research Report
  • [Book] 小児科ピクシス24「症状別検査の選び方・進め方」2011

    • Author(s)
      金兼弘和
    • Total Pages
      4
    • Publisher
      易感染、免疫不全
    • Related Report
      2011 Annual Research Report
  • [Book] 小児がん診療ハンドブック~実地診療に役立つ診断・治療の理念と実践~2011

    • Author(s)
      金兼弘和、大坪慶輔、野村恵子
    • Total Pages
      6
    • Publisher
      免疫不全関連リンパ増殖性疾患
    • Related Report
      2011 Annual Research Report
  • [Book] 血液専門医テキスト2011

    • Author(s)
      金兼弘和
    • Total Pages
      4
    • Publisher
      先天性免疫不全症
    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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