| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Research Abstract |
Cytokine-induced killer(CIK) cells exert strong graft-versus tumor effect(GVT) without causing severe acute graft-versus-host disease(GVHD) in a murine model. However, in some cases CIK cells causes mild chronic GVHD. To reduce chronic GVHD, we studied the role of IL-17, which are involved in the pathogenesis of chronic inflammation, in a murine model. We demonstrated that the mice receiving bone marrow cells from IL-17 knockout mice showed very mild chronic GVHD compared to the mice receiving wild type bone marrow cells. Bone marrow transplantation augmented GVT without causing chronic GVHD might be possible by controlling IL-17.
|
