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The role of CD95-induced apoptosis system in the maturation and differentiation stages of self-antigen specific B cells

Research Project

Project/Area Number 21591352
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKanazawa University

Principal Investigator

KASAHARA Yoshihito  金沢大学, 保健学系, 教授 (30204366)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsアポトーシス細胞死 / アポトーシス / CD95 / B細胞分化
Research Abstract

To examine the functional roles of CD95-induced apoptosis in B cell differentiation and maturation stages, B cell antigen expression and repertoire were analyzed. Increase of CD19-positive, CD20-negative cells including CD38 positive, IgD negative, CD95positive memory B cells, plasmablast and plasma cells were found in circulation in patients with infection and autoimmune disease. These results indicated that anomaly of CD95-induced apoptosis systems in B cell maturation may relate to the pathogenesis of autoimmune disease.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (34 results)

All 2012 2011 2010 2009

All Journal Article (24 results) (of which Peer Reviewed: 24 results) Presentation (10 results)

  • [Journal Article] Human microRNA-1245 downregulates the NKG2D receptor in NK cells and impairs NKG2D-mediated functions2012

    • Author(s)
      Espinoza JL, Takami A, Yoshioka K, Nakata K, Sato T, Kasahara Y, Nakao S
    • Journal Title

      Haematologica

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Monitoring of Epstein-Barr virusinfectedcells by flow cytometer permits early diagnosis and evaluation of disease progression in EBV-associated hemophagocyticlymphohistiocytosis2012

    • Author(s)
      Fukuda M, Nishimura R, Araki R, KurodaR, Mase S, Nakagawa Y, Tone Y, Maeba H, Wada T, Kasahara Y, Yachie A
    • Journal Title

      Rinsho Ketsueki

      Volume: 3 Pages: 337-41

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Japanese StudyGroup of Insulin Therapy for Childhoodand Adolescent Diabetes(JSGIT)2012

    • Author(s)
      Sugihara S, Ogata T, Kawamura T, Urakami T, Takemoto K, Kikuchi N, Takubo N, Tsubouchi K, Horikawa R, Kobayashi K, Kasahara Y, Kikuchi T, Koike A, Mochizuki T, Minamitani K, Takaya R, Mochizuki H, Nishii A, YokotaI, Kizaki Z, Mori T, Shimura N, MukaiT, Matsuura N, Fujisawa T, Ihara K, Kosaka K, Kizu R, Takahashi T, MatsuoS, Hanaki K, Igarashi Y, Sasaki G, Soneda S, Teno S, Kanzaki S, Saji H, Tokunaga K, Amemiya S
    • Journal Title

      Pediatr. Diabetes

      Volume: 1 Pages: 33-44

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] HLA-class II and class 1 genotypes among Japanese children with type 1A Diabetes and their families2012

    • Author(s)
      Sugihara S, Kasahara Y, et al
    • Journal Title

      Pediatr.Diabetes

      Volume: 1 Pages: 33-44

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monitoring of Epstein-Barr virus-infected cells by flow cytometer permits early diagnosis and evaluation of disease progression in EBV-associated hemophagocytic lymphohistiocytosis2012

    • Author(s)
      Fukuda M, Kasahara Y, et al
    • Journal Title

      Rinsho Ketsueki

      Volume: 3 Pages: 337-41

    • NAID

      10030830710

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human microRNA-1245 downregulates the NKG2D receptor in NK cells and impairs NKG2D-mediated functions2012

    • Author(s)
      Espinoza JL,, Kasahara Y, et al
    • Journal Title

      Haematologica

      Volume: 4(掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmunelymphoproliferative syndrome-likedisease with somatic KRAS mutation2011

    • Author(s)
      M. Takagi, K Shinoda, J Piao, NMitsuiki, M Takagi, K Matsuda, HMuramatsu, S Doisaki, M Nagasawa, TMorio, Y Kasahara, K Koike, S Kojima, A Takao, S Mizutani
    • Journal Title

      Blood

      Volume: 117(10) Pages: 2887-90

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accelerated production of multiplecytokines and chemokines byEpstein-Barr virus-infected naturalkiller cells and T cells2011

    • Author(s)
      M Inoue, Y Kasahara, M Akajima, T Toma, M Shimizu, S Koizumi, A, Yachie
    • Journal Title

      J. JuzenMedical Soc

      Volume: 119(4) Pages: 154-163

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmune lymphoproliferative syndro memimicking chronic active Epstein2011

    • Author(s)
      K Nomura, H Kanegane, K Otsubo, HWakiguchi, Y Noda, Y Kasahara, TMiyawaki
    • Journal Title

      Int J Hematol

      Volume: 93 Pages: 760-764

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmune lymphoproliferative syndrome mimicking chronic active Epstein-Barr virus infection2011

    • Author(s)
      K Nomura, Kasahara Y, et al
    • Journal Title

      Int J Hematol

      Volume: 93 Pages: 760-764

    • NAID

      10029535559

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accelerated production of multiple cytokines and chemokines by Epstein-Barr virus-infected natural killer cells and T cells2011

    • Author(s)
      M Inoue, Y Kasahara, et al
    • Journal Title

      十全医学会雑誌

      Volume: 119 Pages: 154-163

    • NAID

      10027787049

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation2011

    • Author(s)
      Takagi M, Kasahara Y, et al
    • Journal Title

      Blood

      Volume: 49 Pages: 2887-90

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinctcytokine profiles of systemic-onsetjuvenile idiopathicarthritis-associated macrophageactivation syndrome with particularemphasis on the role of interleukin-18in its pathogenesis2010

    • Author(s)
      M Shimizu, T Yokoyama, K Yamada, HKaneda, H Wada, T Wada, T Toma, K Ohta, Y Kasahara, A Yachie
    • Journal Title

      Rheumatology

      Volume: 49(9) Pages: 1645-53

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Difference offoot manifestations between young, adult, and bedridden elderly withdiabetes : a cross-sectional observational study2010

    • Author(s)
      Oe M, Okuwa M, Sanada H, Sugama J, Inagaki M, Kasahara Y, Tabata K, Nakagami G, Nishizawa T
    • Journal Title

      J. Soc. NursPractice

      Volume: 22(1) Pages: 19-27

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Secondary anaplastic astrocytomadeveloping in a young adult withautoimmune lymphoproliferativesyndrome(ALPS)2010

    • Author(s)
      D. Kita, Y Hayashi, T Watanabe, AKorshunov, Von Deimling A, M Nakada, YKasahara, Zen Y, Hamada JI, Hayashi Y
    • Journal Title

      Neuropathol ApplNeurobiol

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis2010

    • Author(s)
      M Shimizu, T Yokoyama, K Yamada, HKaneda, H Wada, T Wada, T Toma, K Ohta, Y Kasahara, A Yachie
    • Journal Title

      Rheumatology

      Volume: 49(9) Pages: 1645-53

    • NAID

      120002463521

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hyper IgD andperiodic fever syndrome in Japan2010

    • Author(s)
      河島尚志, 金兼弘和, 森雅亮, 今中啓之, 新庄正宜, 村田卓士, 笠原善仁, 谷口義弘, 杉田完爾, 宮脇利男
    • Journal Title

      J. Tokyo Med Univ

      Volume: 68(2) Pages: 235-238

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hyper IgD and periodic fever syndrome in Japan.2010

    • Journal Title

      J.Tokyo Med Univ.

      Volume: 68 Pages: 235-238

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct cytokine profile of systemic juvenile-idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis2010

    • Author(s)
      Shimizu, M, Kasahara Y, et al
    • Journal Title

      Rheumatology

      Volume: 49 Pages: 1645-1653

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Secondary anaplastic astrocytoma developing in a young adult with autoimmune lymphoproliferative syndrome (ALPS).2010

    • Author(s)
      Kita D, Kasahara Y, et al
    • Journal Title

      Neuropathol AppI Neurobiol

      Volume: 10 Pages: 1365-1365

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation.2010

    • Author(s)
      Takagi M, Kasahara Y, et al
    • Journal Title

      Blood

      Volume: 117 Pages: 2887-2890

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct cytokine profile of systemic juvenile-idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis2010

    • Author(s)
      Shimizu, M, Kasahara Y, et al
    • Journal Title

      Rheumatology (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] M-protein-positive chronicactive Epstein-Barr virus infection : features mimicking HIV-1infection2009

    • Author(s)
      Imashuku S, Azuma N, Kanegane H, Kasahara Y
    • Journal Title

      Int J Hematol

      Volume: 90(2) Pages: 235-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] M-protein-positive chronic active Epstein-Barr virus infection : features mimicking HIV-1 infection2009

    • Author(s)
      Imashuku S, Azuma N, Kanegane H, Kasahara Y.
    • Journal Title

      Int J Hematol. 90

      Pages: 235-8

    • NAID

      10026108532

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 家族性血球貪食性リンパ組織球症2型のCD8+T細胞におけるCD5発現低下2011

    • Author(s)
      榊原康久,和田泰三,東馬智子,谷内江昭宏,笠原善仁,八角高裕,西眞範,小原收
    • Organizer
      第7回血球貪食症候群研究会
    • Place of Presentation
      ベルサール八重洲(東京都)
    • Year and Date
      2011-03-19
    • Related Report
      2011 Final Research Report
  • [Presentation] リツキシマブが有用であった難治性若年性皮膚筋炎の1例2011

    • Author(s)
      佐藤啓,清水正樹,上野和之,横山忠史,笠原善仁,谷内江昭宏
    • Organizer
      第20回日本小児リウマチ学会総会・学術集会
    • Place of Presentation
      沖縄県市町村自治会館(沖縄県)
    • Year and Date
      2011-02-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 家族性血球貪食性リンパ組織球症2型のCD8+T細胞におけるCD5発現低下2011

    • Author(s)
      和田泰三,榊原康久,東馬智,笠原善仁,八角,高西眞範、小原收,谷内江昭宏
    • Organizer
      厚生労働省難治性疾患克服研究事業原発性免疫不全症候群に関する調査研究班平成22年度班会議総会
    • Place of Presentation
      九州大学医学部講堂(福岡県)
    • Year and Date
      2011-01-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Analysisof cytokine, chemokine production bynewly established EBV-positive NK or Tcell lines2010

    • Author(s)
      Kasahara Y, Nishida M
    • Organizer
      第72回日本血液学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2010-09-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 1型糖尿病患者の血槍コントロール目標値の決め方と血糖自己測定の活用2010

    • Author(s)
      川東庸子、稲垣美智子、多崎恵子,笠原善仁
    • Organizer
      第81回日本糖尿病学会中部地方会
    • Place of Presentation
      金沢大学医学類(石川県)
    • Year and Date
      2010-04-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 慢性活動性EBV感染症由来EBV陽性NK/T細胞株の特徴2009

    • Author(s)
      笠原善仁,西田巳香,和田泰三,岡島道子,清水正樹,谷内江昭宏
    • Organizer
      第41回日本小児感染症学会総会・学術集会
    • Place of Presentation
      福井市フェニックス・プラザ(福井県)
    • Year and Date
      2009-11-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Danon病の診断における,フローサイトメトリーを用いたLAMP-2発現解析の有用性.第51回日本先天代謝異常学会総会2009

    • Author(s)
      橋田暢子,斉藤剛克,太田邦雄,笠原善仁,谷内江昭宏
    • Organizer
      第8回アジア先天代謝異常症シンポジウム
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2009-11-05
    • Related Report
      2011 Final Research Report
  • [Presentation] マクロファージ活性化症候群を合併した全身型若年性特発性関節炎におけるサイトカイン動態解析2009

    • Author(s)
      清水正樹,栂暁子,横山忠史,和田泰三,東馬智子,笠原善仁,谷内江昭宏
    • Organizer
      第19回日本小児リウマチ学会総会・学術集会
    • Place of Presentation
      京都リサーチパーク(京都府)
    • Year and Date
      2009-10-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 自然経過中に成長率の回復を認めたempty sellaの一例2009

    • Author(s)
      宮下健悟,西田巳香,岡島道子,谷内江昭宏,笠原善仁
    • Organizer
      第112回日本小児科学会学術集会
    • Place of Presentation
      奈良県文化会館(奈良県)
    • Year and Date
      2009-04-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 母親が未診断であった骨形成不全症V型の母子例2009

    • Author(s)
      横山忠史,笠原善仁,小泉晶一
    • Organizer
      第112回日本小児科学会学術集会
    • Place of Presentation
      奈良県文化会館(奈良県)
    • Year and Date
      2009-04-18
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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