| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
It has been presumed that fibrocytes are involved in airway remodeling in asthmatics as well as repair of damaged tissues and fibrosis. Recently, IL-33 has been attracting attention as an important cytokine that induces the differentiation of Th2 cell, which plays a pivotal role in the pathophysiology of bronchial asthma. In this study, we analyzed the effects of IL-33 on the function of fibrocytes. Fibrocytes expressed IL-33 receptor, ST2. IL-33 enhanced cell proliferation,α-smooth muscle actin expression and MMP9 production of fibrocytes. Dexamethasone suppressed cell proliferation and MMP9 expression of fibrocytes regardless of the presence or absence of IL-33-stimulation. IL-33 not only induces the differentiation of Th2 cells through modulating the function of dendritic cell function but also may play an important role in airway remodeling, a repairing process of allergic inflammation. Steroid seems to effectively inhibit the function of fibrocytes.
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