Analysis of the role of the Notch1 signaling in the onset of acute myeloid leukemia : aiming to establish a new differentiation-inducing therapy.
| Project/Area Number |
21591355
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Yamanashi |
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Principal Investigator |
NAKAMURA Makoto 山梨大学, 大学院・医学工学総合研究部, 医学研究員 (10422685)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Notch1シグナル / 顆粒球分化 / 急性骨髄性白血病 / Notch 1シグナル |
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| Research Abstract |
Our data indicate that Notch1 signaling activation suppresses PU. 1 expression and granulocytic differentiation through a pathway involving MAML1, and maintains a part of myeloid progenitor cells at the immature stage. Therefore, it suggests that aberrant Notch1 signaling could support the granulocytic transformation and the maintenance of the malignant phenotype.
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Report
(4 results)
Research Products
(4 results)
