Analysis of the role of the Notch1 signaling in the onset of acute myeloid leukemia : aiming to establish a new differentiation-inducing therapy.

Research Project

Project/Area Number	21591355
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Pediatrics
Research Institution	University of Yamanashi
Principal Investigator	NAKAMURA Makoto 山梨大学, 大学院・医学工学総合研究部, 医学研究員 (10422685)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	Notch1シグナル / 顆粒球分化 / 急性骨髄性白血病 / Notch 1シグナル
Research Abstract	Our data indicate that Notch1 signaling activation suppresses PU. 1 expression and granulocytic differentiation through a pathway involving MAML1, and maintains a part of myeloid progenitor cells at the immature stage. Therefore, it suggests that aberrant Notch1 signaling could support the granulocytic transformation and the maintenance of the malignant phenotype.

Report

(4 results)