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Molecular genetics and proteomics for gene-environmental relationship in allergy

Research Project

Project/Area Number 21591358
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionGifu University

Principal Investigator

KONDO Naomi  岐阜大学, 医学系研究科, 教授 (50124714)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsアレルギー / 分子遺伝学 / タンパク構造学 / 遺伝因子 / 環境因子 / テーラーメイド治療 / 蛋白構造学 / 遺伝環境相互関係
Research Abstract

The purposes of this study are(1) a analysis of molecular interaction between gene-environment for development of allergic disorders and(2) establishment of personalized medicine for allergic disorders. As results, several related genes for development of allergic disorders were analyzed, a new genetic classification for allergy was established, and personalized medicine for allergic disorders was established based on genetic and molecular analyses.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (19 results)

All 2011 2010 2009 2005

All Journal Article (11 results) (of which Peer Reviewed: 10 results) Presentation (4 results) Book (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Propranolol for intractable diffuse lymphangiomatosis2011

    • Author(s)
      Ozeki M, Fukao T, Kondo N
    • Journal Title

      N Engl J Med

      Volume: 364 Pages: 1380-1382

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Propranolol for intractable diffuse lymp hangiomatosis2011

    • Author(s)
      Ozeki M, Fukao T, Kondo N
    • Journal Title

      N Engl J Med

      Volume: 364 Pages: 1380-1382

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variations in MyD88 adaptor-like are associated with atopic dermatitis2011

    • Author(s)
      An Y, Ohnishi H, Matsui E, Funato M, Kato Z, Teramoto T, Kaneko H, Kimura T, Kubota K, Kasahara K, Kondo N
    • Journal Title

      Int J Mol Med

      Volume: 27 Pages: 795-801

    • NAID

      120006341946

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antigen-specific immune response to endotoxin-free recombinant P34. Allergy2011

    • Author(s)
      Morita H, Kaneko H, Ohnishi H, Kato Z, Kondo N
    • Journal Title

      Allergy

      Volume: 66 Pages: 985-986

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacogenetics of asthma in children2010

    • Author(s)
      Kondo N, Matsui E, Nishimura A, Kaneko H
    • Journal Title

      Allergy Asthma Immunol Res

      Volume: 2 Pages: 14-19

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Japanese pediatric guidelines for the treatment and management of bronchial asthma 20082010

    • Author(s)
      Kondo N, Nishimuta T, Nishima S, Morikawa A, Aihara Y, Akasaka T, Akasawa A, Adachi Y, Arakawa H, Ikarashi T, Ikebe T, Inoue T, Iwata T, Urisu A, Ebisawa M, Ohya Y, Okada K, Odajima H, Katsunuma T, Kameda M, Kurihara K, Kohno Y, Sakamoto T, Shimojo N, Suehiro Y, Tokuyama K, Nambu M, Hamasaki Y, Fujisawa T, Matsui T, Matsubara T, Mayumi M, Mukoyama T, Mochizuki H, Yamaguchi K, Yoshihara S
    • Journal Title

      Pediatr Int

      Volume: 52 Pages: 319-326

    • NAID

      10028182293

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacogenetics of asthma in children.2010

    • Author(s)
      Kondo N, Matsui E, Nishimura A, Kaneko H
    • Journal Title

      Allergy Asthma Immunol Res

      Volume: 2 Pages: 14-19

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] I.遺伝子診断(Genetic Diagnosis) B.各論疾患群の遺伝学的検査(Genetic Testing)と遺伝子検査(Gene-Based Testing)アレルギー疾患2010

    • Author(s)
      近藤直実,松井永子,金子英雄,加藤善一郎,折戸万紀子
    • Journal Title

      遺伝子診療学(第2版)-遺伝子診断の進歩とゲノム治療の展望-

      Volume: 68 Pages: 388-396

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Phamacogenetics of asthma in children.2010

    • Author(s)
      N Kondo.
    • Journal Title

      Allergy Asthma Immunol Res 2

      Pages: 14-19

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japanese pediatric guideline for the treatment and management of bronchial asthma 2008.2010

    • Author(s)
      N Kondo, T Nishimuta, S Nishima., et al.
    • Journal Title

      Pediatr Int (Epub ahead of print)

    • NAID

      10028182293

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ^1H, ^<13>C, and ^<15>N resonance assignment of the backbone of the 17kDa TIR domain of human My88.2010

    • Author(s)
      H Onishi, H Tochio, Z Kato, N kondo., et al
    • Journal Title

      Proc Natl Acad Sci U S A (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 免疫療法その機序と効果-免疫療法の基礎的背景-2011

    • Author(s)
      近藤直実
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 現在と近未来の喘息治療2010

    • Author(s)
      近藤直実
    • Organizer
      小児科医のための喘息フォーラム(第10回)
    • Place of Presentation
      大阪
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] アレルギーの患者と地球に優しい医療とその開発2009

    • Author(s)
      近藤直実
    • Organizer
      第21回日本アレルギー学会春季臨床大会
    • Place of Presentation
      岐阜
    • Year and Date
      2009-06-05
    • Related Report
      2011 Final Research Report
  • [Presentation] アレルギーの患者と地球に優しい医療とその開発2009

    • Author(s)
      近藤直実
    • Organizer
      第21回日本アレルギー学会春季臨床大会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Book] こどものアレルギー診療のポイント2011

    • Author(s)
      近藤直実
    • Total Pages
      135
    • Publisher
      診断と治療社
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Book] 免疫異能性食品の基礎と応用2010

    • Author(s)
      近藤直実
    • Total Pages
      227
    • Publisher
      シーエムシー出版
    • Related Report
      2010 Annual Research Report
  • [Book] アレルギー疾患イラストレイテッド 第2版2010

    • Author(s)
      近藤直実
    • Total Pages
      303
    • Publisher
      メディカルレビュー社
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] Th2サイトカイン阻害剤への感受性の検査方法2005

    • Inventor(s)
      近藤直実
    • Industrial Property Rights Holder
      近藤直実
    • Industrial Property Number
      2005-334787
    • Filing Date
      2005-11-18
    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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