Novel treatment of neuroblastoma by live-attenuated poliovirus

• Project/Area Number: 21591359
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Mie University
• Principal Investigator: TOYODA Hidemi 三重大学, 大学院・医学系研究科, 助教 (60525327)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 神経芽腫 / ポリオウイルス

Research Abstract

In a previous study, we demonstrated that neuroblastoma subcutaneously implanted in immuno-competent mice is eliminated by intratumoral administration of neuroattenuated poliovirus(PV). Our results also suggested that the in vivo destruction of neuroblastoma cells by virotherapy lead to a robust antitumor immune response. In accordance with these findings, we started phase 1 clinical trial, novel treatment of neuroblastoma by live-attenuated poliovirus.

Research Products

• [Journal Article] Oncolytic poliovirus therapy and immunization with poliovirus-infected cell lysate induces potent antitumor immunity against neuroblastoma in vivo (2011)
  • Author(s): Hidemi Toyoda, Jeronimo Cello, and Eckard Wimmer
  • Journal Title: International Journal of Oncology Volume: 38 Pages: 81-87
• [Journal Article] Oncolytic poliovirus therapy and immunization with poliovirus-infected cell lysate induces potent antitumor immunity against neuroblastoma in vivo. (2011)
  • Author(s): Toyoda H, Wimmer E, Cello J
  • Journal Title: International Journal of Oncology Volume: 38 Pages: 81-87
  • Peer Reviewed
• [Journal Article] Elevated von Willebrand factor propeptide for the diagnosis of thrombotic microangiopathy and for predicting poor outcome. (2011)
  • Author(s): Ito-Habe N, Wada H, Matsumoto T, Ohishi K, Toyoda H, et al.
  • Journal Title: International Journal of Hematology Volume: 93 Pages: 47-52
  • NAID: 10029532480
  • Peer Reviewed
• [Journal Article] Multiple cutaneous squamous cell carcinomas in a patient with IFN-γreceptor 2 deficiency (2010)
  • Author(s): Hidemi Toyoda, Masaru Ido, Kyoichi Nakanishi, Takashi Nakano, Hitoshi Kamiya, Akihiko Matsumine, Atsumasa Uchida, Hitoshi Mizutani, Ludovic de Beaucoudrey, Guillaume Vogt, Stephanie Boisson-Dupuis, Jacinta Bustamante, Jean-Laurent Casanova, Yoshihiro Komada
  • Journal Title: Journal of Medical Genetics Volume: 47 Pages: 631-634
• [Journal Article] Multiple cutaneous squamous cell carcinoma in a patient with interferon gamma receptor 2 deficiency. (2010)
  • Author(s): Toyoda H, Ido M, Nakanishi K, Nakano T, Kamiya H, et al.
  • Journal Title: Journal of Medical Genetics Volume: 47 Pages: 631-634
  • Peer Reviewed
• [Journal Article] Prediction of reactivity to noninherited maternal antigen in MHC-mismatched minor histocompatibility antigen-matched stem cell transplantation in a mouse in a mouse (2010)
  • Author(s): Araki M, Hirayama M, Azuma E, Kumamoto T, Iwamoto S, Toyoda H, Ito M, Amano K, Komada Y.
  • Journal Title: Journal of Immunology Volume: 185 Pages: 7739-7745
  • Peer Reviewed
• [Presentation] 招待講演 (2011)
  • Author(s): 豊田秀実
  • Organizer: 第3回大阪小児固形腫瘍研究会
  • Place of Presentation: 大阪大学
  • Year and Date: 2011-04-22
• [Presentation] 招待講演 (2009)
  • Author(s): 豊田秀実
  • Organizer: 骨軟部腫瘍セミナー
  • Place of Presentation: 京都リーガロイヤル
  • Year and Date: 2009-08-29
• [Book] Neuroblastoma-Present and Future (2012)
  • Author(s): Hidemi Toyoda
  • Publisher: In Tech Published