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Novel treatment of neuroblastoma by live-attenuated poliovirus

Research Project

Project/Area Number 21591359
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionMie University

Principal Investigator

TOYODA Hidemi  三重大学, 大学院・医学系研究科, 助教 (60525327)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords神経芽腫 / ポリオウイルス
Research Abstract

In a previous study, we demonstrated that neuroblastoma subcutaneously implanted in immuno-competent mice is eliminated by intratumoral administration of neuroattenuated poliovirus(PV). Our results also suggested that the in vivo destruction of neuroblastoma cells by virotherapy lead to a robust antitumor immune response. In accordance with these findings, we started phase 1 clinical trial, novel treatment of neuroblastoma by live-attenuated poliovirus.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (9 results)

All 2012 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Oncolytic poliovirus therapy and immunization with poliovirus-infected cell lysate induces potent antitumor immunity against neuroblastoma in vivo2011

    • Author(s)
      Hidemi Toyoda, Jeronimo Cello, and Eckard Wimmer
    • Journal Title

      International Journal of Oncology

      Volume: 38 Pages: 81-87

    • Related Report
      2011 Final Research Report
  • [Journal Article] Oncolytic poliovirus therapy and immunization with poliovirus-infected cell lysate induces potent antitumor immunity against neuroblastoma in vivo.2011

    • Author(s)
      Toyoda H, Wimmer E, Cello J
    • Journal Title

      International Journal of Oncology

      Volume: 38 Pages: 81-87

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated von Willebrand factor propeptide for the diagnosis of thrombotic microangiopathy and for predicting poor outcome.2011

    • Author(s)
      Ito-Habe N, Wada H, Matsumoto T, Ohishi K, Toyoda H, et al.
    • Journal Title

      International Journal of Hematology

      Volume: 93 Pages: 47-52

    • NAID

      10029532480

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple cutaneous squamous cell carcinomas in a patient with IFN-γreceptor 2 deficiency2010

    • Author(s)
      Hidemi Toyoda, Masaru Ido, Kyoichi Nakanishi, Takashi Nakano, Hitoshi Kamiya, Akihiko Matsumine, Atsumasa Uchida, Hitoshi Mizutani, Ludovic de Beaucoudrey, Guillaume Vogt, Stephanie Boisson-Dupuis, Jacinta Bustamante, Jean-Laurent Casanova, Yoshihiro Komada
    • Journal Title

      Journal of Medical Genetics

      Volume: 47 Pages: 631-634

    • Related Report
      2011 Final Research Report
  • [Journal Article] Multiple cutaneous squamous cell carcinoma in a patient with interferon gamma receptor 2 deficiency.2010

    • Author(s)
      Toyoda H, Ido M, Nakanishi K, Nakano T, Kamiya H, et al.
    • Journal Title

      Journal of Medical Genetics

      Volume: 47 Pages: 631-634

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of reactivity to noninherited maternal antigen in MHC-mismatched minor histocompatibility antigen-matched stem cell transplantation in a mouse in a mouse2010

    • Author(s)
      Araki M, Hirayama M, Azuma E, Kumamoto T, Iwamoto S, Toyoda H, Ito M, Amano K, Komada Y.
    • Journal Title

      Journal of Immunology

      Volume: 185 Pages: 7739-7745

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 招待講演2011

    • Author(s)
      豊田秀実
    • Organizer
      第3回大阪小児固形腫瘍研究会
    • Place of Presentation
      大阪大学
    • Year and Date
      2011-04-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 招待講演2009

    • Author(s)
      豊田秀実
    • Organizer
      骨軟部腫瘍セミナー
    • Place of Presentation
      京都リーガロイヤル
    • Year and Date
      2009-08-29
    • Related Report
      2011 Final Research Report
  • [Book] Neuroblastoma-Present and Future2012

    • Author(s)
      Hidemi Toyoda
    • Publisher
      In Tech Published
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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