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Role of Rab family small G proteins in determining the prognosis of neuroblastoma patients

Research Project

Project/Area Number 21591361
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKobe University

Principal Investigator

LEE Myeongjin  神戸大学, 大学院・医学研究科, 非常勤講師 (20273766)

Co-Investigator(Kenkyū-buntansha) NISHIMURA Noriyuki  神戸大学, 大学院・医学研究科, 准教授 (00322719)
西尾 久英  神戸大学, 医学研究科, 教授 (80189258)
Co-Investigator(Renkei-kenkyūsha) NISHIO Hisahide  神戸大学, 大学院・医学研究科, 教授 (80189258)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords神経芽腫 / 予後決定因子 / Rab15 / 選択的スプライシング / レチノイン酸 / がん幹細胞 / 自然消退 / Rab / 細胞極性
Research Abstract

Neuroblastoma is an aggressive solid tumor that accounts for approximately 15% of all cancer-related deaths in children. More than half of high-risk neuroblastoma patients are estimated to experience relapses and their overall survival rates remain less than 40%. Identification of a new prognostic factor is essential to improve the prognosis of neuroblastoma patients. Aberrant alternative splicing is intimately associated with an increasing number of cancers, and its use as a new diagnostic and/or prognostic biomarker has attracted considerable attention. In the present study, we identified four alternatively spliced isoforms of Rab15, originally isolated as a brain-specific Rab protein. Rab15 isoform balance correlated with differentiation of neuroblastoma tumor-initiating cells(TICs) and Rab15 alternative splicing may serve as a biomarker to discriminate TICs from non-TICs in neuroblastoma.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report

Research Products

(8 results)

All 2012 2011 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 5 results)

  • [Journal Article] Rab15 alternative splicing is altered in spheres of neuroblastoma cells2012

    • Author(s)
      Pham TVH, Hartomo TB, Lee MJ, Hasegawa D, Ishida T, Kawasaki K, Kosaka Y, Yamamoto T, Morikawa S, Yamamoto N, Kubokawa I, Mori T, Yanai T, Hayakawa A, Takeshima Y, Iijima K, Matsuo M, Nishio H and Nishimura N
    • Journal Title

      Oncol. Rep

      Volume: 27 Pages: 2045-2049

    • Related Report
      2011 Final Research Report
  • [Journal Article] Epigallocatechin gallate inhibits sphere formation of neuroblastoma BE(2)-C cells2012

    • Author(s)
      Nishimura N, Hartomo TB, Pham TVH, Lee MJ, Yamamoto T, Morikawa S, Hasegawa D, Takeda H, Kawasaki K, Kosaka Y, Yamamoto N, Kubokawa I, Mori T, Yanai T, Hayakawa A, Takeshima Y, Iijima K, Matsuo M, Nishio H
    • Journal Title

      Environ. Health Prev. Med

      Volume: 17 Pages: 246-251

    • NAID

      10030617244

    • Related Report
      2011 Final Research Report
  • [Journal Article] Rab15 alternative splicing is altered in spheres of neuroblastoma cells2012

    • Author(s)
      Pham, TVH.
    • Journal Title

      Oncol. Rep

      Volume: (in press)(掲載確定) Pages: 2045-2049

    • DOI

      10.3892/or.2012.1731

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigallocatechin gallate inhibits sphere formation of neuroblastoma BE(2)-C cells2012

    • Author(s)
      Nishimura, N.
    • Journal Title

      Environ Health Prev Med

      Volume: (in press)(掲載確定) Issue: 3 Pages: 246-251

    • DOI

      10.1007/s12199-011-0239-5

    • NAID

      10030617244

    • ISSN
      1342-078X, 1347-4715
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rab15 expression correlates with retinoic acid-induced differentiation of neuroblastoma cells2011

    • Author(s)
      Nishimura N, Pham TVH, Hartomo TB, Lee MJ, Hasegawa D, Takeda H, Kawasaki K, Kosaka Y, Yamamoto T, Morikawa S, Yamamoto N, Kubokawa I, Mori T, Yanai T, Hayakawa A, Takeshima Y, Nishio H and Matsuo M
    • Journal Title

      Oncol. Rep

      Volume: 26 Pages: 145-151

    • Related Report
      2011 Final Research Report
  • [Journal Article] Rab15 expression correlates with retinoic acid-induced differentiation of neuroblastoma cells2011

    • Author(s)
      Nishimura, N.
    • Journal Title

      Oncol. Rep.

      Volume: 26 Pages: 145-151

    • DOI

      10.3892/or.2011.1255

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rab family small G proteins in regulation of epithelial apical junctions.2009

    • Author(s)
      Nishimura, N.
    • Journal Title

      Front.Biosci. 14

      Pages: 2115-2129

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rab15 expression correlates with retinoic acid-induced differentiation of neuroblastoma cells.

    • Author(s)
      Nishimura, N.
    • Journal Title

      Oncol.Rep.

      Volume: (In Press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2009-03-31   Modified: 2016-04-21  

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