| Project/Area Number |
21591363
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
|
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| Research Institution | Kyushu University |
|---|
Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
DOI Takehiko 九州大学, 大学病院, 特任助教 (20572100)
TANAKA Tamami 九州大学, 大学院・医学研究院, 学術研究員 (60423547)
堤 康 九州大学, 大学病院, 助教 (80419564)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 原発性免疫不全症候群 / リンパ球分化 / エキソーム解析 / 血液細胞・リンパ球分化 / マイクロアレイ |
|---|
| Research Abstract |
We clarified a new pathway of lymphoid differentiation, which was suggested by a novel primary immunodeficiency, by making humanized mice recapitulating the disease. To elucidate the responsible gene which encodes the key molecule in the development of B cells, NK cells and plasmacytoid dendritic cells, we analyzed genes which are reported to play important roles in lymphoid development. Although we further performed exome analysis of 2 patients with this disease, we have not determined the cause of this disease, yet.
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