The molecular mechanism of human lymphopoesis
| Project/Area Number |
21591363
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
DOI Takehiko 九州大学, 大学病院, 特任助教 (20572100)
TANAKA Tamami 九州大学, 大学院・医学研究院, 学術研究員 (60423547)
堤 康 九州大学, 大学病院, 助教 (80419564)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 原発性免疫不全症候群 / リンパ球分化 / エキソーム解析 / 血液細胞・リンパ球分化 / マイクロアレイ |
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| Research Abstract |
We clarified a new pathway of lymphoid differentiation, which was suggested by a novel primary immunodeficiency, by making humanized mice recapitulating the disease. To elucidate the responsible gene which encodes the key molecule in the development of B cells, NK cells and plasmacytoid dendritic cells, we analyzed genes which are reported to play important roles in lymphoid development. Although we further performed exome analysis of 2 patients with this disease, we have not determined the cause of this disease, yet.
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Report
(4 results)
Research Products
(73 results)
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[Journal Article] High incidence of NLRP3 somatic mosaicism in patients with chronic infantile neurologic, cutaneous, articular syndrome2011
Author(s)
Tanaka N, Izawa K, Saito MK, Sakuma M, Oshima K, Ohara O, Nishikomori R, Morimoto T, Kambe N, Goldbach-Mansky R, Aksentijevich I, de Saint Basile G, Neven B, van Gijn M, Frenkel J, Arostegui JI, Yague J, Merino R, Ibanez M, Pontillo A, Takada H, Imagawa T
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Journal Title
Arthritis Rheum
Volume: 63
Issue: 11
Pages: 3625-32
DOI
Related Report
Peer Reviewed
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[Presentation] Normal and Pathological Development of Human B Cells in NOD/SCID/IL2rgnull Mice Transplanted with Normal and BTK Gene-Mutated Human HSC_s2010
Author(s)
Doi T, Takada H, Kanegane H, Tomizawa M, Saito Y, Miyawaki T, Watanabe T, Ohara 0, Ishii F, Shultz LD., Hara T, Ishikawa F
Organizer
The 14th International Congress of Immunology(ICI 2010)
Place of Presentation
Kobe, Japan
Related Report
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[Presentation] Rapid diagnostic system of primary immunodeficiency diseases in Japan2009
Author(s)
Hara T, Takada H, Ishimura M, Imai K, Nonoyama S, Ariga T, Tsuchiya S, Morio T, Kamachi Y, Yachie A, Nunoi H, Kobayashi M, Nakahata T, Kanegane H, and Miyawaki T
Organizer
The 5th Congress of Asian Society for Pediatric Research
Place of Presentation
Hangzhou, China
Related Report
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[Presentation] Successful cord blood transplantation for a CHARGE syndrome with CHD7 mutation showing characteristic triad of DiGeorge syndrome including hypoparathyroidism2009
Author(s)
Takada H, Inoue H, Ishimura M, Kusuda T, Goto T, Ochiai M, Kinjo T, Muneuchi J, Takahata Y, Kosaki K, Hara T
Organizer
The 5th Congress of Asian Society for Pediatric Research
Place of Presentation
Hangzhou, China
Related Report
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