possible inhibitory action of omega-3 unsatulated fatty acid on development of childhood asthma
| Project/Area Number |
21591364
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 気道上皮 / 気道炎症 / 脂肪酸代謝物 / 小児気管支喘息 / アラキドン酸代謝物 / semaphirin3A / 気道上皮細胞 / air-liquid interface (ALI) / 好中球 / ω-脂肪酸 / 気管支喘息 / ロイコトリエンB4 / resolution / resolvin / protectin / ω-3脂肪酸 / lipoxin |
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| Research Abstract |
Childhood asthma has been known to be a chronic airway inflammation which is characterized by infiltration of inflammatory cells including lymphocytes, mast cells, eosinophils and PMNs. We investigated action of various bioactive substances including unsaturated fatty acid-metabolites and cytokines in human and murine cultured airway epithelial cells.(1) Leukotrienes(LTB4), a substance of unsaturated fatty acid induced ICAM-1 expression on cultured human airway epithelial cells, indicating important roles in the process of virus-induced inflammation of airway.(2) Poly IC induced sema3A in cultured human airway epithelial cells. Sema3A increased phagocytotic function of human PMNs.(3) IL-13 was confirmed to stimulate proliferation of cultured murine tracheal epithelial cells by using air-liquid interface assay. This proliferative action is associated with new induction of epigen, which is a substance of epidermal growth factor receptor(EGFR) ligand family.
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Report
(4 results)
Research Products
(25 results)
