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The etiology of food allergy and inflammatory bowel diseases in children inrelation to peptides derived from digested food proteins.

Research Project

Project/Area Number 21591372
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionJuntendo University

Principal Investigator

OHTSUKA Yoshikazu  順天堂大学, 医学部, 准教授 (90338335)

Co-Investigator(Kenkyū-buntansha) SHIMIZU Toshiaki  順天堂大学, 医学部, 教授 (30260889)
NAGATA Satoru  順天堂大学, 医学部, 准教授 (70266055)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords消化 / 食物アレルギー / 炎症性腸疾患 / 新生児・乳児消化管アレルギーリンパ濾胞 / Probiotics / 栄養療法 / 消化機能
Research Abstract

To investigate the etiology of food allergy and inflammatory bowel diseases(IBD) in children in relation to peptides derived from digested food proteins, their antigenicity was analyzed ; however, no specific reactions were confirmed in serum derived from food allergy or IBD. We have also investigated the mucosal samples taken from food protein-induced proctocolitis(FPIP) and IBD with microarray, RT-PCR, immunohistochemistry and found that the lymphoid hyperplasia with eosinophilic infiltration into the colonic mucosa in response to CCL11 and CXCL13 signaling is important in FPIP while CXCL9 and CXCR3 are the key molecules in pediatric IBD.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (53 results)

All 2012 2011 2010 2009 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (33 results) Book (4 results) Remarks (2 results)

  • [Journal Article] Effects of Bifidobacterium breve on inflammatory gene expression in neonatal anweaning rat intestine2012

    • Author(s)
      Ohtsuka Y, Ikegami T, Izumi H, Namura M, Ikeda T, Ikuse T, Baba Y, Kudo T, Suzuki R, Shimizu T.
    • Journal Title

      Pediatr Res.

      Volume: 72 Pages: 46-53

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microarray analysis of mucosal biopsies in neonates with rectal bleeding : Is it really an allergic disease2012

    • Author(s)
      Ohtsuka Y, Jimbo K, Inage E, Mori M, Yamakawa Y, Aoyagi Y, Suzuki M, Kudo T, Suzuki R, Shimizu T.
    • Journal Title

      J Allergy Clin Immunol

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microarray analysis of mucosal biopsies in neonates with rectal bleeding : Is it really an allergic disease?2012

    • Author(s)
      Ohtsuka Y, Jimbo K, Inage E, et al
    • Journal Title

      J Allergy Clin Immunol

      Volume: 129([Epub ahead of print]Feb 11) Issue: 6 Pages: 1676-1678

    • DOI

      10.1016/j.jaci.2012.01.042

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Four distinct subtypes of non-IgE-mediated gastrointestinal food allergies in neonates and infants, distinguished by their initial symptoms2011

    • Author(s)
      Nomura I, Morita H, Hosokawa S, Hoshina H, Fukuie T, Watanabe M, Ohtsuka Y, Shoda T, Terada A, Takamasu T, Arai K, Ito Y, Ohya Y, Saito H, Matsumoto K.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 127 Pages: 685-688

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pulse steroids as induction therapy for children with ulcerative colitis2011

    • Author(s)
      Kudo T, Nagata S, Ohtani K, Fujii T, Wada M, Haruna H, Shoji H, Ohtsuka Y, Shimizu T, Yamashiro Y.
    • Journal Title

      Pediatr Int

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Four distinct subtypes of non-IgE-mediated gastrointestinal food allergies in neonates and infants, distinguished by their initial symptoms2011

    • Author(s)
      Nomura I, Morita H, Ohtsuka Y, et al
    • Journal Title

      J Allergy Clin Immunol

      Volume: 127 Issue: 3 Pages: 685-688.e8

    • DOI

      10.1016/j.jaci.2011.01.019

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulse steroids as induction therapy for children with ulcerative colitis2011

    • Author(s)
      Kudo T, Nagata S, Ohtsuka Y, et al
    • Journal Title

      Pediatr Int

      Volume: 53 Issue: 6 Pages: 974-9

    • DOI

      10.1111/j.1442-200x.2011.03405.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monitoring 6-thioguanine nucleotide concentrations in Japanese children and adolescents with inflammatory bowel disease2010

    • Author(s)
      Ohtsuka Y, Arai K, Aoyagi Y, Fujii T, Yamakawa Y, Ohtani K, Ikuse T, Baba Y, Inage E, Kudo T, Suzuki R, Nagata S, Shimizu T.
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 25 Pages: 1626-30

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical efficacy of leukotriene receptor antagonist in children with food allergy2010

    • Author(s)
      Yamakawa Y, Ohtsuka Y, Ohtani K, Fujii T, Nagata S, Shimizu T.
    • Journal Title

      Drugs R D.

      Volume: 10 Pages: 147-54

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of mizoribine in children with inflammatory bowel disease2010

    • Author(s)
      Fujii T, Ohtsuka Y, Yamakawa Y, Ohtani K, Kudo T, Ohtomo Y, Nagata S, Shimizu T.
    • Journal Title

      Pediatr Int

      Volume: 52

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peroxisome proliferator-activated receptor mutation may cause a subset of ulcerative colitis2010

    • Author(s)
      Aoyagi Y, Nagata S, Kudo T, Fujii T, Wada M, Chiba Y, Ohtsuka Y, Yamashiro Y, Shimizu T, Ohkusa T
    • Journal Title

      Pediatr Int

      Volume: 52 Pages: 729-34

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The increased expression of GATA-3 but T-bet observed in the mucosa from children with acute phase of inflammatory bowel disease2009

    • Author(s)
      Ohtani K, Ohtsuka Y, Ikuse T, Baba Y, Yamakawa Y, Aoyagi Y, Fujii T, Kudo T, Nagata S, Shimizu T.
    • Journal Title

      Pediatr Int

      Pages: 584-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] プランルカストを投与した新生児一過性好酸球性大腸炎の1例2009

    • Author(s)
      佐藤洋明, 大塚宜一, 森真理, 佐藤圭子, 東海林宏道, 清水俊明
    • Journal Title

      小児科

      Volume: 50 Pages: 1521-1524

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 新生児・乳児消化管アレルギーの病態消化管局所における病態2009

    • Author(s)
      大塚宜一, 馬場洋介, 幾瀬圭, 山川陽子, 藤井徹, 青柳陽, 東海林宏道, 工藤孝広, 鈴木竜洋, 佐藤洋明, 清水俊明
    • Journal Title

      日本小児アレルギー学会雑誌

      Volume: 23 Pages: 18-24

    • NAID

      10026284258

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Monitoring 6-thioguaninenucleotide concentrations in Japanese children and adolescents with inflammatory bowel disease2012

    • Author(s)
      Ohtsuka Y, Arai K, Aoyagi Y, Fujii T, Ikuse T, Kudo T, Shimizu T.
    • Organizer
      6th Korea-Japan IBD Symposium
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2012-01-02
    • Related Report
      2011 Final Research Report
  • [Presentation] 新生児乳児消化管アレルギー患児の粘膜を用いた病態の解析2011

    • Author(s)
      大塚宜一, 石田明日香, 神保圭祐, 稲毛英介, 馬場洋介, 森真理, 山川陽子, 和田万里子, 工藤孝広, 鈴木竜洋, 清水俊明
    • Organizer
      第61回日本アレルギー学会秋季大会ミニシンポジウム
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 新生児・乳児消化管アレルギー患児の粘膜を用いた病態の解析第2報2011

    • Author(s)
      大塚宜一, 石田明日香, 神保圭祐, 他
    • Organizer
      第61回日本アレルギー学会秋季大会ミニシンポジウム
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Microarray and histological analysis of food. protein induced enterocolitis syndrome2011

    • Author(s)
      Ohtsuka Y, Ishida A, Inage E, Baba Y, Mori M, Yamakawa Y, Wada M, Suzuki R, Shimizu T.
    • Organizer
      APAPARI mini-symposium
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2011-10-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Microarray and histological analysis of food-protein induced enterocolitis syndrome2011

    • Author(s)
      Ohtsuka Y, Ishida A, Inage E, et al
    • Organizer
      Asia Pacific Association of Pediatric Allergy, Respirology & Immunology 2011, mini-symposium
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2011-10-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新生児・乳児消化管アレルギーの病態の解析2011

    • Author(s)
      大塚宜一, 神保圭祐, 稲毛英介, 幾瀬圭, 山川陽子, 青柳陽, 藤井徹, 工藤孝広, 永田智, 清水俊明
    • Organizer
      第38回日本小児栄養消化器肝臓学会
    • Place of Presentation
      ホテル紫苑(盛岡)
    • Year and Date
      2011-10-09
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 消化管アレルギーから見た小児の粘膜免疫2011

    • Author(s)
      大塚宜一
    • Organizer
      第74回日本小児アレルギー同好会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 小児期炎症性腸疾患の炎症と免疫2011

    • Author(s)
      大塚宜一
    • Organizer
      第114回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-08-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 小児期消化器疾患の臨床-便秘,下痢,血便を中心に2011

    • Author(s)
      大塚宜一
    • Organizer
      第23回海匝地区小児懇話会
    • Place of Presentation
      千葉
    • Year and Date
      2011-07-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 小児期消化器疾患の臨床-便秘,下痢,血便を中心に2011

    • Author(s)
      大塚宜一
    • Organizer
      山梨県小児科医会山梨県小児保健協会学術集会
    • Place of Presentation
      山梨
    • Year and Date
      2011-06-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 小児期慢性腸疾患の病態と免疫2011

    • Author(s)
      大塚宜一
    • Organizer
      第325回順天堂医学会学術集会
    • Place of Presentation
      東京(有山記念講堂)
    • Year and Date
      2011-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Microarray analysis of food. protein induced enterocolitis syndrome by comparison with inflammatory bowel disease in children2011

    • Author(s)
      Ohtsuka Y, Inage E, Baba Y, Kudos T, Shimizu T.
    • Organizer
      PAS/ASPR
    • Place of Presentation
      Denver Convention Center(Denver)
    • Year and Date
      2011-04-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Microarray analysis of food-protein induced enterocolitis syndrome by comparison with inflammatory bowel disease in children2011

    • Author(s)
      Ohtsuka Y, Inage E, Baba Y, et al
    • Organizer
      Pediatric Academic Society 2011/Asian Society for Pediatric Research
    • Place of Presentation
      Denver Convention Center (Denver)
    • Year and Date
      2011-04-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新生児・乳児消化管アレルギー新生児・乳児消化管アレルギー患児の粘膜病変について2010

    • Author(s)
      大塚宜一
    • Organizer
      第47回日本小児アレルギー学会シンポジウム
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2010-12-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 新生児・乳児消化管アレルギー患児の粘膜病変について2010

    • Author(s)
      大塚宜一
    • Organizer
      第47回 日本小児アレルギー学会
    • Place of Presentation
      横浜
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新生児・乳児消化管アレルギー新生児・乳児消化管アレルギー患児の粘膜を用いた病態の解析2010

    • Author(s)
      大塚宜一
    • Organizer
      第60回日本アレルギー学会秋季大会ミニシンポジウム
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2010-11-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 新生児・乳児消化管アレルギー患児の粘膜を用いた病態の解析2010

    • Author(s)
      大塚宜一
    • Organizer
      第60回 日本アレルギー学会秋季大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児期の血便とIBD2010

    • Author(s)
      大塚宜一
    • Organizer
      文京区医師会勉強会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Microarrayを用いた小児期炎症性腸疾患の病態の検討2010

    • Author(s)
      大塚宜一
    • Organizer
      第37回 日本小児栄養消化器肝臓学会
    • Place of Presentation
      高松
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] ミニシンポジウム「小児の食物アレルギー」消化管アレルギー2010

    • Author(s)
      大塚宜一
    • Organizer
      第22回 日本アレルギー学会春季臨床大会
    • Place of Presentation
      京都
    • Year and Date
      2010-05-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児の食物アレルギー消化管アレルギー2010

    • Author(s)
      大塚宜一
    • Organizer
      第22回日本アレルギー学会春季臨床大会ミニシンポジウム
    • Place of Presentation
      国立京都国際館(京都)
    • Year and Date
      2010-05-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 乳幼児期における食物アレルギーへの対応法2010

    • Author(s)
      大塚宜一
    • Organizer
      足立区小児科医会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2010-01-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Microarrayを用いた小児期炎症性腸疾患の病態の検討2010

    • Author(s)
      大塚宜一, 櫻井由美子, 藤武義人, 稲毛英介, 幾瀬圭, 馬場洋介, 鈴木光幸, 青柳陽, 藤井徹, 工藤孝広, 清水俊明
    • Organizer
      第37回日本小児栄養消化器肝臓学会
    • Place of Presentation
      かがわ国際会議場(高松)
    • Related Report
      2011 Final Research Report
  • [Presentation] 仔ラット消化管粘膜におけるprobioticsの抗炎症効果について2009

    • Author(s)
      大塚宜一, 藤井徹, 鈴木竜洋, 永田智, 和泉裕久, 名村真理子, 峯岸真梨緒, 稲毛英介, 山川陽子, 松原知代, 清水俊明
    • Organizer
      第46回日本小児アレルギー学会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2009-12-06
    • Related Report
      2011 Final Research Report
  • [Presentation] 好酸球性腸炎としての新生児・乳児消化管アレルギー2009

    • Author(s)
      大塚宜一, 久田研, 東海林宏道, 佐藤洋明, 清水俊明
    • Organizer
      第54回未熟児新生児学会パネルデイスカッション
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-11-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Microarrayを用いた仔ラット消化管粘膜に与えるprobioticsの効果の検討2009

    • Author(s)
      大塚宜一, 櫻井由美子, 和泉裕久, 名村真理子, 峯岸真梨緒, 馬場洋介, 幾瀬圭, 藤井徹, 鈴木竜洋, 永田智, 稲毛英介, 山川陽子, 松原知代, 清水俊明
    • Organizer
      第59回日本アレルギー学会秋季学術大会ミニシンポジウム
    • Place of Presentation
      秋田ビューホテル(秋田)
    • Year and Date
      2009-10-31
    • Related Report
      2011 Final Research Report
  • [Presentation] B. breveの仔ラット消化管粘膜に与える効果について2009

    • Author(s)
      大塚宜一, 和泉裕久, 名村真理子, 峯岸真梨緒, 馬場洋介, 幾瀬圭, 稲毛英介, 大谷清孝, 山川陽子, 青柳陽, 藤井徹, 工藤孝広, 東海林宏道, 鈴木竜洋, 永田智, 清水俊明
    • Organizer
      第36回日本小児栄養消化器肝臓学会
    • Place of Presentation
      北海道大学学術交流会館(札幌)
    • Year and Date
      2009-10-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 小児炎症性腸疾患における免疫調節薬の使用状況について2009

    • Author(s)
      大塚宜一, 藤井徹, 鈴木竜洋, 永田智, 新井勝大, 稲毛英介, 山川陽子, 松原知代, 清水俊明
    • Organizer
      第19回日本小児リウマチ学会
    • Place of Presentation
      京都リサーチパーク(京都)
    • Year and Date
      2009-10-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 小児の炎症性腸疾患について2009

    • Author(s)
      大塚宜一
    • Organizer
      第568回日本小児科学会東京都地方会講話会指定発言
    • Place of Presentation
      東京
    • Year and Date
      2009-09-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 炎症性腸疾患について本邦と欧米の治療法の違い2009

    • Author(s)
      大塚宜一
    • Organizer
      江東ブロック病勤薬剤師会平成21年度4月例会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 小児炎症性腸疾患における免疫調節薬の使用状況2009

    • Author(s)
      大塚宜一, 大谷清孝, 藤井徹, 幾瀬圭, 青柳陽, 鈴木竜洋, 清水俊明
    • Organizer
      第5回日本消化管学会総会学術集会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2009-02-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 「アレルギー関連領域の診断と治療」新生児・乳児消化管アレルギーの診断と治療2009

    • Author(s)
      大塚宜一
    • Organizer
      第17回小児臨床薬理・アレルギー・免疫研究会シンポジウム4
    • Place of Presentation
      宇都宮
    • Year and Date
      2009-02-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 新生児・乳児消化管アレルギー(FPIES)と新生児一過性好酸球性腸炎(NTEC)2009

    • Author(s)
      大塚宜一
    • Organizer
      第563回日本小児科学会東京都地方会講話会指定発言
    • Place of Presentation
      東京
    • Year and Date
      2009-01-10
    • Related Report
      2011 Final Research Report
  • [Book] 周産期のアレルギー,出生後の抗菌薬使用はアレルギー疾患と関係するか.周産期のアレルギー,出生後の抗菌薬使用はアレルギー疾患と関係するか.周産期医学2011

    • Author(s)
      大塚宜一, 清水俊明
    • Related Report
      2011 Final Research Report
  • [Book] ライフスパンから見た小児科診療,炎症性腸疾患.小児内科2011

    • Author(s)
      大塚宜一
    • Related Report
      2011 Final Research Report
  • [Book] 好酸球性胃腸炎.小児臨床栄養学2011

    • Author(s)
      大塚宜一, 他.児玉浩子, 玉井浩, 清水俊明
    • Publisher
      診断と治療社
    • Related Report
      2011 Final Research Report
  • [Book] 小児科臨床ピクシス18下痢・便秘食物アレルギーと下痢2010

    • Author(s)
      大塚宜一, 他.五十嵐隆, 清水俊明
    • Publisher
      中山書店
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.juntendo.ac.jp/graduate/kenkyudb/search/researcher.php?MID=1777

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.juntendo.ac.jp/graduate/kenkyudb/search/researcher.php?MID=1777

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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