The study for the relationship between the quantity of Ascaris antigen in the house dust and asthma symptoms of children living in the rural area of Bangladesh

• Project/Area Number: 21591373
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Tokyo Kasei University
• Principal Investigator: IWATA Tsutomu 東京家政大学, 家政学部・児童学科, 教授 (00134578)
• Co-Investigator(Kenkyū-buntansha): NAKAZAWA Takuya 国立病院機構相模原病院, 臨床研究センター, 室長 (50297686) ; KANO Hirotsugu 帝京大学, 医学部附属溝口病院, 准教授 (60292942)
• Co-Investigator(Renkei-kenkyūsha): TAKEUCHI Haruko 神奈川県立保健福祉大学, 教授 ; KHAN Md al fazal ICDDR, B(バングラデシュ国際下痢生疾患研究所), Principal Investigator
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 小児免疫 / アレルギー / 膠原病学 / バングラデシュ / 室内塵 / 回虫抗原 / 気管支喘息

Research Abstract

So-called hygiene hypothesis means that better hygienic environment introduce less allergic diseases. This hypothesis is still controversial especially in the developing country where the ascaris infection is mostly endemic. We had published a paper concerning the epidemiological data which showed the morbidity of wheezing is about 16% in Bangladeshi children. The morbidity of ascaris infestation is over 70% in the rural area in Bangladesh. Our data threw the issue against the hygiene hypothesis. We had also showed that high amount of anti-ascaris IgE antibody significantly correlated to the morbidity of wheezy episodes, diagnosed as the bronchial asthma. We hypothesized there might be ascaris antigen in the house-dust which worked as the inhalant allergen. We surveyed the same field in the rural Bangladesh as the one surveyed in 2001.ISAAC questionnaire was used. Sixty one children out of 142(43%) who were wheezy group in 2001 showed wheezing episode yet after 10 years and 79 out of 97(81%) who were not wheezy showed no wheezing episode. This difference was statistically significant by chi square test(p<0.0001). House dust was collected from the bedding of these two groups. Higher amount of ascaris antigen(5.25μg/g dust, 1.15～ 9.36, 95% CI) was detected in the house dust of the wheezy group than the non-wheezy group(2.54μg/g dust, 1.67～ 3.41, 95% CI), although statistically not significant. The newly developed method for detecting ascaris antigen has some limitation, because something was detected from the dust which was collected from Japanese housing. Our result suggested that there might be cross-reactive materials other than ascaris antigen in those house dust collected from two countries. Further research is needed.

Research Products

• [Journal Article] Japanese pediatric guidelines for the treatment and management of bronchial asthma 2008 (2010)
  • Author(s): Naomi Kondo, Toshiyuki Nishimuta, Sankei Nishima, Akihiro Morikawa, Yuko Aihara, Toru Akasaka, Akira Akasawa, Yuichi Adachi, Hirokazu Arakawa, Takao Ikarashi, Toshiichi Ikebe, Toshishige Inoue, Tsutomu Iwata, Atsuo Urisu, Motohiro Ebisawa, Yukihiro Ohya, Kenji Okada, Hiroshi Odajima, Toshio Katsunuma, Makoto Kameda, Kazuyuki Kurihara, Yoichi Kohno, Tatsuo Sakamoto, Naoki Shimojo, Yutaka Suehiro, Kenichi Tokuyama, Mitsuhiko Nambu, Yuhei Hamasaki, Takao Fujisawa, Takehiko Matsui, Tomoyo Matsubara, Mitsufumi, Mayumi, Tokuko Mukoyama, Hirohuki Mochizuki, Koichi Yamaguchi and Shigemi Yoshihara
  • Journal Title: Pediatrics International Volume: 52(2) Pages: 319-326
  • NAID: 10028182293
• [Journal Article] 1歳未満の気管支喘息に対するオノンドライシロップ10%(プランルカスト水和物)製造販売後調査結果(第2報)-長期投与例の追跡調査- (2010)
  • Author(s): 岩田力、栗原和幸、小田島安平、宇理須厚雄、井上壽茂、河野陽一、森川昭廣
  • Journal Title: 日本小児アレルギー学会誌 Volume: 24(5) Pages: 693-704
• [Journal Article] Japanese pediatric guidelines for the treatment and management of bronchial asthma 2008 (2010)
  • Author(s): Naomi Kondo, Toshiyuki Nishimuta, Sankei Nishima, Akihiro Morikawa, Yuko Aihara, Toru Akasaka, Akira Akasawa, Yuichi Adachi, Hirokazu Arakawa, Takao Ikarashi, Toshiichi Ikebe, Toshishige Inoue, Tsutomu Iwata, Atsuo Urisu, Motohiro Ebisawa, Yukihiro Ohya, Kenji Okada, Hiroshi Odajima, Toshio Katsunuma, Makoto Kameda, Kazuyuki Kurihara, Yoichi Kohno, Tatsuo Sakamoto, Naoki Shimojo, Yutaka Suehiro, Kenichi Tokuyama, Mitsuhiko Nambu, Yuhei Hamasaki, Takao Fujisawa, Takehiko Matsui, Tomoyo Matsubara, Mitsufumi, Mayumi, Tokuko Mukoyama, Hirohuki Mochizuki, Koichi Yamaguchi, Shigemi Yoshihara
  • Journal Title: Pediatrics International Volume: 52 Pages: 319-326
  • NAID: 10028182293
  • Peer Reviewed
• [Journal Article] Improvement of deficient natural killer activity and delayed bactericidal activity by a thiol proteinase inhibitor, E-64-d, in leukocytes from Chediak-Higashi syndrome patients in vitro (2009)
  • Author(s): Fuminori Tanabe, Hirotake Kasai, Limin He, Tomohiro Kin, Takashi Fujimoto, Toshihide Kumamoto, Toshiro Hara, Tsutomu Iwata, Masahiko Ito
  • Journal Title: International Immunopharmacology Volume: 9 Pages: 3663-3670
• [Journal Article] Acute allergic reaction due to milk proteins contaminating lactose added to corticosteroid for injection (2009)
  • Author(s): Asuka Eda, Kazuko Sugai, Hiromi Shioya, Asako Fujitsuka, Setsuko Ito, Tsutomu Iwata and Tetsunori Funabiki
  • Journal Title: Allergology International Volume: 58(1) Pages: 137-139
  • NAID: 10025109384
• [Journal Article] 患者教育・学校保健ミニ特集小児気管支喘息治療・管理ガイドライン2008-ここがポイント- (2009)
  • Author(s): 岩田力
  • Journal Title: 小児科臨床 Volume: 62(3) Pages: 421-427
  • NAID: 120006623559
• [Journal Article] 序～アレルギー疾患の治癒ということ～ (2009)
  • Author(s): 岩田力
  • Journal Title: アレルギー・免疫 Volume: 16(4) Pages: 475-476
• [Journal Article] 1歳未満の気管支喘息に対するオノンドライシロップ10%(プランルカスト水和物)製造販売後調査結果レトロスペクティヴ調査 (2009)
  • Author(s): 岩田力
  • Journal Title: 小児科臨床 Volume: 62(5) Pages: 987-1000
• [Journal Article] 小児気管支喘息治療・管理ガイドライン2008早期治療と長期管理 (2009)
  • Author(s): 岩田力
  • Journal Title: アレルギー Volume: 58(5) Pages: 507-511
• [Journal Article] 2歳未満のいわゆる乳児喘息 (2009)
  • Author(s): 岩田力
  • Journal Title: 小児内科 Volume: 41(10) Pages: 1511-1512
• [Journal Article] 1歳未満の気管支喘息に対するオノンドライシロップ10%(プランルカスト水和物)製造販売後調査結果-プロスペクティヴ調査- (2009)
  • Author(s): 岩田力、栗原和幸、小田島安平、宇理須厚雄、井上壽茂、河野陽一、森川昭廣
  • Journal Title: 日本小児アレルギー学会誌 Volume: 23(5) Pages: 629-642
  • NAID: 10026284904
• [Presentation] SOTI研究グループ:食物アレルギーに対する急速経口免疫療法:多施設RCTの経過 (2011)
  • Author(s): 伊藤直香、下条直樹、藤澤隆夫、岩田力
  • Organizer: 第23回日本アレルギー学会春季臨床大会
  • Place of Presentation: 幕張
  • Year and Date: 2011-05-14
• [Presentation] 鶏卵の急速免疫療法中に腸管症状により治療継続困難となった2症例 (2011)
  • Author(s): 小山晴美、八木久子、石毛崇、荒川浩一、伊藤浩明、漢人直之、岩田力
  • Organizer: 第23回日本アレルギー学会春季臨床大会
  • Place of Presentation: 幕張
  • Year and Date: 2011-05-14
• [Presentation] 経口負荷試験でアナフィラキシーショックを呈した卵アレルギーの一女児例 (2011)
  • Author(s): 板澤寿子、足立雄一、伊藤直香、下条直樹、藤澤隆夫、岩田力、宮脇利男
  • Organizer: 第23回日本アレルギー学会春季臨床大会
  • Place of Presentation: 幕張
  • Year and Date: 2011-05-14
• [Presentation] 環境中におけるヒト回虫抗原の検出法の開発 (2010)
  • Author(s): 中澤卓也、齋藤明美、安枝浩、竹内治子、狩野博嗣、岩田力
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-25
• [Presentation] The comparison of two predictive formulae for the spirometric parameters in Japanese children (2010)
  • Author(s): T. Iwata, Y. Kodachi, H. Kano, H. Hara, H. Takeuchi, Y. Tokoeda
  • Organizer: XXIX Congress of EAACI
  • Place of Presentation: London, Great Britain
• [Presentation] The pattern of the flow volume curve in non-asthmatic children aged 12-15 years (2009)
  • Author(s): Iwata, T ; Kodachi, Y ; Kano, H ; Hara, H ; Takeuchi, H
  • Organizer: XXVIII Congress of the European Academy of Allergy and Clinical Immunology
  • Place of Presentation: Warszawa, Poland