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Analysis of the role of Chitinase 3 like 1in atopic dermatitis development

Research Project

Project/Area Number 21591375
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

YOSHIDA Hisahiro  独立行政法人理化学研究所, アレルギー免疫遺伝研究チーム, チームリーダー (20281090)

Co-Investigator(Renkei-kenkyūsha) 安田 琢和  独立行政法人理化学研究所, アレルギー免疫遺伝研究チーム, 研究員 (00373374)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsアトピー性皮膚炎 / キチナーゼ様タンパク質 / 表皮バリア破壊 / 尋常性魚鱗癬 / Filaggrin / Tight junction / 衛生環境 / 信号伝達 / キチナーゼ様物質 / 皮膚免疫 / Th2誘導 / Chi3l1トランスジェニックマウス / Chi3l1KOマウス / Chitinase3like1 / 無菌飼育環境 / 皮膚常在細菌 / 黄色ブドウ球菌 / Th2からTh1への推移 / 自然免疫系 / Staphylococcus Aureus / 無菌状態下でのマウス / Spadeマウス / keratinocyte / 常在細菌
Research Abstract

We have found the over expression of Chi3l1 in epidermis of the newly identified atopic dermatitis model mouse before the onset of disease. Overexpression of Chi3l1 transgene in epidermis resulted in skin barrier permeability destruction and ichthyosis vulgaris like appearance, In addition, in conventional condition, the AD model mouse showed similar appearance and tight junction protein expression was down-regulated. These findings indicated Chi3l1 protein play a role in skin barrier formation.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (19 results)

All 2012 2011 2010 2009

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (5 results) Book (1 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 3 results)

  • [Journal Article] Expression pattern changes and function of RANKL during mouse lymph node microarchitecture development2012

    • Author(s)
      Sugiyama M, Nakato G, Jinnohara T, Akiba H, Okumura K, Ohno H, Yoshida H
    • Journal Title

      Int Immunol

      Volume: 24(6) Pages: 369-78

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development and Function of Invariant Natural Killer T cells Producing T_H2-and T_H17-cytokines2012

    • Author(s)
      Hiroshi Watarai, Etsuko Sekine-Kondo, Tomokuni Shigeura, Yasutaka Motomura, Takuwa Yasuda, Rumi Satoh, Hisahiro Yoshida, Masato Kubo, Hiroshi Kawamoto, Haruhiko Koseki, Masaru Taniguchi
    • Journal Title

      PLoS Biology

      Volume: 10(2)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression pattern changes and function of RANKL during mouse lymph node microarchitecture development2012

    • Author(s)
      Sugiyama, et al.
    • Journal Title

      International Immunology

      Volume: 24 Issue: 6 Pages: 369-378

    • DOI

      10.1093/intimm/dxs002

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and Function of Invariant Natural Killer T cells Producing Th2- and Th17-cytokines2012

    • Author(s)
      Watarai, et al.
    • Journal Title

      PLoS Biology

      Volume: 10

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Runx1/Cbfβ2 complexes are required for lymphoid tissue inducer cell differentiation at two developmental stages2011

    • Author(s)
      Tachibana M, Tenno M, Tezuka C, Sugiyama M, Yoshida H, Taniuchi I
    • Journal Title

      J Immunol

      Volume: 186(3) Pages: 1450-7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Runx1/Cbf β2 complexes are required for lymphoid tissue inducer cell differentiation at two developmental stages2011

    • Author(s)
      Masashi Tachibana
    • Journal Title

      J Immunol.

      Volume: 186 Pages: 1450-1457

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] xCT definiency accelerates chemically induced tumorigenesis2010

    • Author(s)
      Ami Nabeyama
    • Journal Title

      xCT definiency accelerates chemically induced tumorigenesis

      Volume: 107 Pages: 6436-6441

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An atopic dermatitis-like skin disease with hyper-IgE-emia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2 (Act1/CIKS) gene2010

    • Author(s)
      Yoshibumi Matsushima
    • Journal Title

      The Journal of Immunology

      Volume: 185 Pages: 2340-2349

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel gene essential for the development of single positive thymocytes2009

    • Author(s)
      Kakugawa K.
    • Journal Title

      Mol Cell Biol. 29

      Pages: 5128-35

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of an improved mouse model for infantile neuroaxonal dystrophy that shows early disease onset and bears a point mutation in Pla2g62009

    • Author(s)
      Wada H.
    • Journal Title

      Am J Pathol. 175

      Pages: 2257-63

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Complicated Expression Profile of RANKL and Its Function in Peripheral Lymphoid Organ Development2011

    • Author(s)
      杉山真知子, etal.
    • Organizer
      日本免疫学会
    • Place of Presentation
      千葉市
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] ミュタジェネシスを利用したアレルギー疾患モデル開発2010

    • Author(s)
      吉田 尚弘
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Stepwise progressive atopic dermatitis induced by a signaling molecule hyperactivation2010

    • Author(s)
      Takuwa YASUDA, Hisahiro YOSHIDA
    • Organizer
      Laboratory for Immunogenetics, RIKEN Research Center for Allergy and Immunology 14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] 新たに樹立した Stepwise progressive atopic dermatitis マウスは獲得免疫非依存的にアトピー性皮膚炎を発症する2009

    • Author(s)
      安田琢和, 吉田尚弘
    • Organizer
      第39回日本免疫学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2009-12-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] アトピー性皮膚炎を自然発症するENUミュータントマウスでの発症には非血球系の細胞が重要な役割を果たす2009

    • Author(s)
      安田琢和, 吉田尚弘
    • Organizer
      第59回日本アレルギー学会秋季学術集会
    • Place of Presentation
      秋田キャッスルホテル他(秋田市)
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Book] 疾患モデルマウス表現型解析指南免疫系免疫p304-p3152011

    • Author(s)
      山村研一, et al.
    • Total Pages
      477
    • Publisher
      中山書店
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 皮膚炎症性疾患の診断方法2011

    • Inventor(s)
      吉田尚弘、安田琢和、若菜茂晴、久保允人
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Patent Publication Number
      2011-083279
    • Acquisition Date
      2011-04-28
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 皮膚炎症性疾患の診断方法2010

    • Inventor(s)
      吉田尚弘、安田琢和、若菜茂晴、久保允人
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Industrial Property Number
      2010-208532
    • Filing Date
      2010-09-16
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] アメリカ特許出願2010

    • Inventor(s)
      吉田尚弘, et al.
    • Industrial Property Rights Holder
      理化学研究所
    • Filing Date
      2010-09-24
    • Related Report
      2011 Annual Research Report
    • Overseas

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Published: 2009-04-01   Modified: 2018-01-18  

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