| Project/Area Number |
21591378
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
LI Yuanyuan 千葉県がんセンター(研究所), 研究局, 研究員 (00392259)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Ohko 千葉県がんセンター(研究所), 主席研究員 (60260254)
|
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAGAWARA Akira 千葉県がんセンター(研究所), センター長 (50117181)
HARAGUCHI Seiki 千葉県がんセンター(研究所), 研究員 (10324576)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 神経芽腫 / 依存性受容体 / アポトーシス / 分化 / UNC5D |
|---|
| Research Abstract |
Nerve growth factor(NGF) dependency is responsible for developmentally programmed cell death(PCD) of normal peripheral neurons as well as spontaneous regression of neuroblastoma(NB), a childhood solid tumor arising from sympathoadrenal lineage. However the molecular mechanism remains elusive. In this study, we found that the dependence receptor UNC5D was involved in NGF deprivation-induced cell death in neuroblastoma through the nuclear translocation of its intracellular fragment released by caspase 2/3.Our findings indicate that UNC5D may play a critical role in accelerating cell death during regression of neuroblastoma, which could be a tool to develop new therapeutic strategies against high-risk tumors.
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