Functional role of the dependence receptor UNC5D in regulation Of cell death in neuroblastoma
Project/Area Number |
21591378
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Chiba Cancer Center (Research Institute) |
Principal Investigator |
LI Yuanyuan 千葉県がんセンター(研究所), 研究局, 研究員 (00392259)
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Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Ohko 千葉県がんセンター(研究所), 主席研究員 (60260254)
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Co-Investigator(Renkei-kenkyūsha) |
NAKAGAWARA Akira 千葉県がんセンター(研究所), センター長 (50117181)
HARAGUCHI Seiki 千葉県がんセンター(研究所), 研究員 (10324576)
|
Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 神経芽腫 / 依存性受容体 / アポトーシス / 分化 / UNC5D |
Research Abstract |
Nerve growth factor(NGF) dependency is responsible for developmentally programmed cell death(PCD) of normal peripheral neurons as well as spontaneous regression of neuroblastoma(NB), a childhood solid tumor arising from sympathoadrenal lineage. However the molecular mechanism remains elusive. In this study, we found that the dependence receptor UNC5D was involved in NGF deprivation-induced cell death in neuroblastoma through the nuclear translocation of its intracellular fragment released by caspase 2/3.Our findings indicate that UNC5D may play a critical role in accelerating cell death during regression of neuroblastoma, which could be a tool to develop new therapeutic strategies against high-risk tumors.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] High expression of ncRAN, a novel non-coding RNA mapped to chromosome 17q25.1, is associated with poor prognosis in neuroblastoma2009
Author(s)
Yu M, Ohira M, Li Y, Niizuma H, Oo ML, Zhu Y, Ozaki T, Isogai E, Nakamura Y, Koda T, Oba S, Yu B, Nakagawara A
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Journal Title
Int. J. Oncol
Volume: 34
Issue: 4
Pages: 931-938
DOI
Related Report
Peer Reviewed
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[Journal Article] Plk3 inhibits pro-apoptotic adivity of p73 through physical interadion and phosphorylation2009
Author(s)
Sang M, Ando K, Okoshi R, Koida N, Li Y, Zhu Y, Shimozato O, Geng C, Shan B, Nakagawara A, Ozaki T.
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Journal Title
Genes Cells 14(7)
Pages: 775-788
Related Report
Peer Reviewed
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[Journal Article] High expression of ncRAN, a novel non-coding RNA mapped to chromosome 17q25.1, is associated with poor prognosis in neuroblastoma2009
Author(s)
Yu M, Ohira M, Li Y, Niizuma H, Oo ML, Zhu Y, Ozaki T, Isogai E, Nakamura Y, Koda T, Oba S, Yu B, Nakagawara A.
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Journal Title
Int J Oncol 34(4)
Pages: 931-938
Related Report
Peer Reviewed
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[Presentation] UNC5D, a dependence receptor for netrin-1, induces apoptosis in neuroblastoma through nuclear translocation of its cleaved intracellular fragment2009
Author(s)
Yuanyuan Li, Yuyan Zhu, Miki Ohira, Atsuko Nakagawa, Kiyoshi Asada, Toshikazu Ushijima, Yohko Nakamura, Hirofumi Arakawa, Akira Nakagawara
Organizer
第25回日本小児がん学会総会
Place of Presentation
パシフィコ横浜(千葉県)
Year and Date
2009-11-27
Related Report
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[Presentation] UNC5D, a dependence receptor for netrin-1, is down-regulated in unfavorable neuroblastomas2009
Author(s)
Yuyan Zhu, Yuanyuan Li, Miki Ohira, Atsuko Nakagawa, Kohei Akazawa, Meng Yu, Yohko Nakamura, Tadayuki Koda, Patrick Mehlen, Hirofumi Arakawa, Akira Nakagawara
Organizer
AACR
Place of Presentation
Colorado Convention Center(Denver, Colorado)
Year and Date
2009-04-20
Related Report