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The role of Cspg-2 gene in embryonic cardiovascular development

Research Project

Project/Area Number 21591383
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionTokyo Women's Medical University (2011)
The University of Tokyo (2009-2010)

Principal Investigator

NAKAOKA Takashi  東京女子医科大学, 医学部, 准教授 (80241256)

Co-Investigator(Kenkyū-buntansha) TOMITA Sachiko  東京女子医科大学, 医学部, 助教 (40231451)
ISO Naoyuki  東京大学, 医科学研究所, 助教 (80420214)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords発生学・形態形成学 / 先天異常学・奇形学 / 心血管 / 発生 / 分化 / バーシカン / 循環器・高血圧
Research Abstract

The expression of the Cspg2 gene, which encodes the extracellular matrix protein, versican, is disrupted in the heart defect(hdf) mouse. Therefore, the hdf mouse is a good model to examine the function of Cspg2 gene in embryonic cardiovascular development. The vascular formation was disrupted particularly at the dorsal region of the hdf embryos and that the second heart field segment was diminished in hdf embryos. The initial delamination of the neural crest from the neural tube epithelium appeared to be normal, however, the transformed neural crest cells were disrupted in hdf mouse embryos. Versican, may protect cephalic mesenchyme from massive apoptosis, thereby contributing to the neural crest cells and the cells in second heart field.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (48 results)

All 2012 2011 2010 2009

All Journal Article (13 results) (of which Peer Reviewed: 5 results) Presentation (33 results) Book (2 results)

  • [Journal Article] 神経堤細胞におけるバーシカンの意義2012

    • Author(s)
      高部智哲、宮川-富田幸子、中岡隆志, 他4名
    • Journal Title

      東京女子医科大学雑誌

      Volume: (in press)

    • NAID

      110009423408

    • Related Report
      2011 Final Research Report
  • [Journal Article] Profiling of immune-related microRNA expression in human cord blood and adult peripheral blood cells upon proinflammatory stimulation2012

    • Author(s)
      Takahashi N, Nakaoka T, Yamashita N
    • Journal Title

      Eur. J. Haematol

      Volume: 88巻 Pages: 31-38

    • Related Report
      2011 Final Research Report
  • [Journal Article] Profiling of immune-related microRNA expression in human cord blood and adult peripheral blood cells upon proinflammatory stimulation2012

    • Author(s)
      Takahashi N, Nakaoka T, Yamashita N
    • Journal Title

      Eur.J.Haematol.

      Volume: 81 Pages: 31-38

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tenascin C may regulate the recruitment of smooth muscle cells during coronary artery development2011

    • Author(s)
      Ando K, Takahashi M, Miyagawa-Tomita S, 他4名
    • Journal Title

      Differentiation

      Volume: 81巻 Pages: 299-306

    • Related Report
      2011 Final Research Report
  • [Journal Article] Effects of transforming growth factor-. 3 and matrix metalloproteinase-3on the pathogenesis of chronic mitral valvular disease in dogs2011

    • Author(s)
      Obayashi K, Miyagawa-Tomita S, 他4名
    • Journal Title

      Am. J. Vet. Res

      Volume: 72巻 Pages: 194-202

    • Related Report
      2011 Final Research Report
  • [Journal Article] A case of Cor Triatriatum with an abnormal P wave : The pacemaker action from the specialized tissue in the abnormal septum2011

    • Author(s)
      Kudo Y, Kaneko M, Nakazawa M, Tomita S
    • Journal Title

      Pediatric Cardiology

      Volume: 32巻 Pages: 1244-1248

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Tenascin C may regulate the recruitment of smooth muscle cells during coronary artery development2011

    • Author(s)
      Ando K, Takahashi M, Yamagishi T, Miyagawa-Tomita S, Imanaka-Yoshida K, Yoshida T, Nakajima Y
    • Journal Title

      Differentiation

      Volume: 81 Pages: 299-306

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of transforming growth factor-β3 and matrix metalloproteinase-3 on the pathogenesis of chronic mitral valvular disease in dogs2011

    • Author(s)
      Obayashi K, Miyagawa-Tomita S, Matsumoto H, Koyama H, Nakanishi T, Hirose H
    • Journal Title

      Am.J.Vet.Res.

      Volume: 72 Pages: 194-202

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelin receptor Type A expression defines a distinct cardiac subdomain within the heart field and later implicated in chamber myocardium formation2010

    • Author(s)
      Asai R, Miyagawa-Tomita S, 他9名
    • Journal Title

      Development

      Volume: 137巻 Pages: 3823-3833

    • Related Report
      2011 Final Research Report
  • [Journal Article] Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries2010

    • Author(s)
      Watanabe Y, Miyagawa-Tomita S, Buckingham ME, 他3名
    • Journal Title

      Circulation Research

      Volume: 106巻 Pages: 495-503

    • Related Report
      2011 Final Research Report
  • [Journal Article] Endothelin receptor Type A expression defines a distinct cardiac subdomain within the heart field and later implicated in chamber myocardium formation.2010

    • Author(s)
      Asai R, Kurihara Y, Fujisawa K, Sa to T, Kawamura Y, Kokubo H, Tonami K, Nishiyama K, Uchijima Y, Mivagawa-Tomita S.Kurihara H
    • Journal Title

      Development

      Volume: 137 Pages: 3823-3833

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries.2010

    • Author(s)
      Watanabe Y, 宮川-富田幸子, Vincent SD, Kelly RG, Moon AM, Buckingham ME
    • Journal Title

      Circulation Research 106

      Pages: 495-503

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 冠血管の発生2009

    • Author(s)
      宮川-富田幸子, ら
    • Journal Title

      細胞 14

      Pages: 6-9

    • Related Report
      2009 Annual Research Report
  • [Presentation] 「臨床時間生物学の現状と展望」高齢者の健康に対する時間生物学的検討2011

    • Author(s)
      中岡隆志、大塚邦明
    • Organizer
      第18回日本時間生物学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-11-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 「臨床時間生物学の現状と展望」高齢者の健康に対する時間生物学的検討2011

    • Author(s)
      中岡隆志、大塚邦明
    • Organizer
      第18回日本時間生物学会学術大会
    • Place of Presentation
      名古屋(招待講演)
    • Year and Date
      2011-11-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel roles of the neural crest in coronary artery formation through endothelin signaling2011

    • Author(s)
      Miyagawa-Tomita S, Arima S, Kurihara H
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒストンメチラーゼG9aおよびGLPの心筋細胞特異的欠損マウスにおける心臓形態形成異常の解析2011

    • Author(s)
      牧野智行、宮川-富田幸子, 他3名
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Novel roles of the neural crest in coronary artery formation through endothelin signaling2011

    • Author(s)
      Miyagawa-Tomita S, Arima S, Kurihara H
    • Organizer
      The 34th Annual Meeting of the Molecular Biology Society of Japan, Working symposium
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Coronary artery anomalies in Endothelin-1 and Endothelin A receptor knockout mice2011

    • Author(s)
      Yuichiro Arima, Sachiko Miyagawa-Tomita, 他7名
    • Organizer
      Scientific Sessions of the American Heart Association
    • Place of Presentation
      Orlando, FL, USA
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Neural crest cells contribute to coronary artery development through endothelin signaling2011

    • Author(s)
      Yuichiro Arima, Sachiko Miyagawa-Tomita, 他7名
    • Organizer
      第19回日本血管生物医学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Hesr2 disruped mice develop aortic valve disease with advancing age2011

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, 他3名
    • Organizer
      Weinstein Cardiovasc Developmental Meeting
    • Place of Presentation
      Cincinnati, Ohio, USA
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Endothelin receptor type-A expression defines a distinct subdomain, within the heart field and contributes to chamber myocardium2011

    • Author(s)
      Asai R, Miyagawa-Tomita S, 他5名
    • Organizer
      Weinstein Cardiovasc Developmental Meeting
    • Place of Presentation
      Cincinnati, Ohio, USA
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Matricellular protein, tenascin-C, may regulate proepi/epicardial cell function during coronary vessel development2011

    • Author(s)
      Imanaka Y, Miyagawa-Tomita S, 他5名
    • Place of Presentation
      Cincinnati, Ohio, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Matricellular protein, tenascin-C, may regulate proepi/epicardial cell function during coronary vessel development2011

    • Author(s)
      Imanaka Y, Ando K, Takahashi M, Yamagishi T, Yoshida T, Nakajima Y, Miyagawa-Tomita S
    • Organizer
      Weinstein Cardiovasc Developmental Meeting
    • Place of Presentation
      Cincinnati, Ohio, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒストンメチラーゼG9aおよびGLPの心筋細胞特異的欠損マウスにおける心臓形態形成異常の解析2011

    • Author(s)
      牧野智行、宮川-富田幸子、立花誠、眞貝洋一、竹内隆
    • Organizer
      Scientific Sessions of the American Heart Association
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Tenascin C may regulate recruitment of mural cells during coronary arterial development2010

    • Author(s)
      Imanaka-Yoshida K, Miyagawa-Tomita S, 他4名
    • Organizer
      Weinstein Cardiovascular Development Conference
    • Place of Presentation
      Amsterdam, Netherland
    • Related Report
      2011 Final Research Report
  • [Presentation] TGF-. 3 and MMP3 contribute to pathogenesis of myxomatous mitral valve in canine2010

    • Author(s)
      Obayashi K, Miyagawa-Tomita S, 他4名
    • Organizer
      Weinstein Cardiovascular Development Conference
    • Place of Presentation
      Amsterdam, Netherland
    • Related Report
      2011 Final Research Report
  • [Presentation] Endothelin type-A receptor expression defines a distinct subdomain within the crescent-forming heart field contributing to chamber myocardium2010

    • Author(s)
      Asai R, Miyagawa-Tomita S, 他8名
    • Organizer
      Weinstein Cardiovascular Development Conference
    • Place of Presentation
      Amsterdam, Netherland
    • Related Report
      2011 Final Research Report
  • [Presentation] The transcriptional repressor prdm1/blimp1 is required within the second heart field for the morphogenesis of the distal outflow tract2010

    • Author(s)
      Vincent SD, Miyagawa-Tomita S, Buchingham M
    • Organizer
      Weinstein Cardiovascular Development Conference
    • Place of Presentation
      Amsterdam, Netherland
    • Related Report
      2011 Final Research Report
  • [Presentation] Tenascin C may regulate recruitment of mural cells during coronary arterial develonment.2010

    • Author(s)
      Imanaka-Yoshida K, et al.
    • Organizer
      Weinstein Cardiovascular Development Conference, 49
    • Place of Presentation
      Amsterdam, Netherland
    • Related Report
      2010 Annual Research Report
  • [Presentation] TGF-β3 and MMP3 contribute to pathogenesis of myxomatous mitral valve in canine.2010

    • Author(s)
      Obayashi K, et al.
    • Organizer
      Weinstein Cardiovascular Development Conference, 49
    • Place of Presentation
      Amsterdam, Netherland
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endothelin type-A receptor expression defines a distinct subdomain within the crescent-forming heart field contributing to chamber mvocardium.2010

    • Author(s)
      Asai R, et al.
    • Organizer
      Weinstein Cardiovascular Development Conference, 49
    • Place of Presentation
      Amsterdam, Netherland
    • Related Report
      2010 Annual Research Report
  • [Presentation] The transcriptional repressor prdml/blimpl is required within the second heart field for the mornhogenesis of the distal outflow tract.2010

    • Author(s)
      Vincen SD, et al.
    • Organizer
      Weinstein Cardiovascular Development Conference, 49
    • Place of Presentation
      Amsterdam, Netherland
    • Related Report
      2010 Annual Research Report
  • [Presentation] 成獣Hesr2ノックアウトマウスの心機能解析.2010

    • Author(s)
      中鴬八隅、宮川一富田幸子, 他3名
    • Organizer
      第46回日本小児循環器学会
    • Place of Presentation
      シェラトン・グランデ・トーキョーベイ・ホテル
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endothelin type-A receptor expression defines a distinct subpopulation within the first heart field contributing to chamber myocardium.2010

    • Author(s)
      浅井理恵子, 他10名
    • Organizer
      第33回日本分子生物学会
    • Place of Presentation
      神戸国際展示場
    • Related Report
      2010 Annual Research Report
  • [Presentation] 僧帽弁閉鎖不全症発症におけるTGFβの役割2009

    • Author(s)
      大林浩二、宮川-富田幸子, ら
    • Organizer
      第147回日本獣医学会
    • Place of Presentation
      栃木
    • Related Report
      2009 Annual Research Report
  • [Presentation] Tenascin-C expression and neural crest are associated with formation of the coronary orifice.2009

    • Author(s)
      宮川-富田幸子, et al.
    • Organizer
      Weinstein Cardiovascular Developmental Conference
    • Place of Presentation
      カリフォルニア、米国
    • Related Report
      2009 Annual Research Report
  • [Presentation] Endothelin type-A receptor expression defines a distinct subdomain within the crescent-forming heart field contributing to chamber myocardium2009

    • Author(s)
      浅井理恵子, et al.
    • Organizer
      Weinstein Cardiovascular Developmental Conference
    • Place of Presentation
      カリフォルニア、米国
    • Related Report
      2009 Annual Research Report
  • [Presentation] The transcriptional repressor prdm1/blimp1 is required within the second heart field for the morphogenesis of the distal outflow tract2009

    • Author(s)
      Vincent SD, 宮川-富田幸子, et al.
    • Organizer
      Weinstein Cardiovascular Developmental Conference
    • Place of Presentation
      カリフォルニア、米国
    • Related Report
      2009 Annual Research Report
  • [Presentation] Endothelin typeA-receptor expression defines a distinct subpopulation within the first heart field contributing to chamber myocardium.2009

    • Author(s)
      浅井理恵子, et al.
    • Organizer
      42^<nd> Ann Meet Jpn Soc Dev Biol
    • Place of Presentation
      新潟
    • Related Report
      2009 Annual Research Report
  • [Presentation] 僧帽弁閉鎖不全症発症におけるTGFβ3およびMMP3の役割2009

    • Author(s)
      大林浩二、宮川-富田幸子, ら
    • Organizer
      日本臨床獣医学会
    • Place of Presentation
      埼玉
    • Related Report
      2009 Annual Research Report
  • [Presentation] 僧帽弁粘液腫様変性におけるTGFβの役割2009

    • Author(s)
      大林浩二、宮川-富田幸子, ら
    • Organizer
      第45回日本小児循環器学会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] 心臓円錐動脈幹と鰓弓動脈の発生における中胚葉性fgf8とfgf10の機能解析2009

    • Author(s)
      渡辺祐介、宮川-富田幸子, ら
    • Organizer
      第8回心臓血管発生研究会
    • Place of Presentation
      福島
    • Related Report
      2009 Annual Research Report
  • [Presentation] テネイシンCによる心臓血管新生の制御2009

    • Author(s)
      今中-吉田恭子, ら
    • Organizer
      第13回Molecular Cardiovascular Conference
    • Place of Presentation
      小樽
    • Related Report
      2009 Annual Research Report
  • [Presentation] Tenascin C regulates recruitment of smooth muscle cells during coronary arterial development.2009

    • Author(s)
      Ando K, et al.
    • Organizer
      49^<th> Ann Meeting of the American Society for Cell Biology
    • Place of Presentation
      カリフォルニア、米国
    • Related Report
      2009 Annual Research Report
  • [Presentation] Endothelin type-A receptor expression defines a distinct subdomain wthin the first heart field contributing to chamber myocardium.2009

    • Author(s)
      浅井理恵子, ら
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      神奈川
    • Related Report
      2009 Annual Research Report
  • [Book] Annual Review循環器2011心臓発生と心筋分化誘導のマスター因子2011

    • Author(s)
      竹内純, 宮川-富田幸子, 他2名
    • Publisher
      中外医学社
    • Related Report
      2011 Final Research Report
  • [Book] Annual Review循環器2011心臓発生と心筋分化誘導のマスター因子pp1-162011

    • Author(s)
      竹内純、宮川-富田幸子、笹岡陽介、小柴和子
    • Total Pages
      365
    • Publisher
      中外医学社
    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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