Role of IL-6-Th17/Treg system in the development of experimental pulmonary hypertension
| Project/Area Number |
21591385
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUMAMOTO Tadashi 三重大学, 大学院・医学系研究科, 助教 (50362348)
MARUYAMA Kazuo 三重大学, 大学院・医学系研究科, 教授 (20181828)
SHIMPO Hideto 三重大学, 大学院・医学系研究科, 教授 (70179076)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 肺高血圧 / 動物モデル / IL-6 / IL-17 / Treg / Tリンパ球 |
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| Research Abstract |
We demonstrated that perivascular inflammatory cell infiltration may be temporally and spatially associated with the development of experimental pulmonary hypertension. Specifically, we showed that these infiltrating inflammatory cells contributed to the disease formation via releasing inflammation-related cytokines, IL-6 and IL-17. Further investigation is required to elucidate the role of these cytokines in the development of a new animal model, mimicking human pulmonary arterial hypertension.
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Report
(4 results)
Research Products
(51 results)
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[Presentation] Impact Of Public-Access Defibrillation At School On The Outcome After Out-Of-Hospital Cardiac Arrest Of Cardiac Origin In Elementary And Middle School Students : A Japanese Nationwide Survey2010
Author(s)
Mitani Y, Ohta K, Ichida F, Nii M, Arakaki Y, Ushinohama H, Ohashi H, Yodoya N, Tateno S, Sato S, Suzuki T, Higaki T, Iwamoto M, Yoshinaga M, Sumitomo N.
Organizer
American Heart Association
Place of Presentation
Chicago, USA
Year and Date
2010-11-16
Related Report
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[Presentation] Bosentan promotes incorporation of bone marrow-derived endothelial cells but inhibits infiltration of macrophages into pulmonary vascular lesions in mice exposed to chronic hypoxia : A novel concept of bosentan therapy in pulmonary hypertension2009
Author(s)
Kato T, Sawada H, Maruyama J, Ikeyama Y, Masuya M, Miyata E, Nakamura S, Shimpo H, Maruyama K, Komada Y, Mitani Y.
Organizer
American Heart Association
Place of Presentation
Orland (US)
Year and Date
2009-11-17
Related Report
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