Research on the pathogenesis and treatment of Epstein-Barr virusassociated intractable diseases

• Project/Area Number: 21591388
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kyushu University
• Principal Investigator: OHGA Shouichi 九州大学, 医学研究院, 教授 (60233053)
• Co-Investigator(Kenkyū-buntansha): TANAKA Tamami 九州大学, 医学(系)研究科(研究院), 学術研究員 (60423547)
• Co-Investigator(Renkei-kenkyūsha): IMADOME Ken-ichi 国立成育医療センター研究所, 母児感染研究部, 感染防御研究室室長 (70392488) ; OHSHIMA Koichi 久留米大学医学部, 第2病理学教室, 教授 (50203766)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 小児感染症学 / EBウイルス / リンパ増殖性疾患 / 血球貪食症候群 / 免疫化学療法 / 造血細胞移植

Research Abstract

In patients with chronic active Epstein-Barr virus infection(CAEBV) or EBVassociated hemophagocytic syndrome(EBV-HLH), EBVpositive T/NK cells were suggested to arise from hematopoietic progenitors and need CD4positive cells for the clonal proliferation in a distinct manner from tumorigenesis. Early immunomodulatory therapy effectively controlled EBV-HLH in children with primary infection. Long-term outcomes of pediatric patients were favorable after hematopoietic stem cell transplantation, while adult patients had poor outcomes. Characterization of EBVinfected T/NK cells is critical for the establishment of treatment strategy.

Research Products

• [Journal Article] Reducedintensity conditioning in unrelated donor cord blood transplantation for patients with familial hemophagocytic lymphohistiocytosis (2012)
  • Author(s): Nishi M, Nishimura R, Suzuki N, Sawada A, Okamura T, Fujita N, Kanai R, Yano J, Adachi S, Yasumi T, Sate E, Yasutomo K, Ishii E, Ohga S
  • Journal Title: Am J Hematol
  • Peer Reviewed
• [Journal Article] Acute liver failure as the initial manifestation of Wilson disease trigerred by human parvovirus Big infection (2012)
  • Author(s): Shiraishi A, Hoshina T, Ihara K, Doi T, Ohga S, Hara T
  • Journal Title: Pediatr Infect Dis J Volume: 31(1) Pages: 103-104
  • Peer Reviewed
• [Journal Article] CD4+ T cells have a critical role in the proliferation of EBVinfected T and NK cells (2012)
  • Author(s): Imadome K, Yajima M, Alai A, NakagawaNakazawa A, Kawano F, Ichikawa S. Shimizu N, Yamamoto N, Morie T, Ohga S, Nakamura H, Ito M, Miura 0, Komano J, Fujiwara S
  • Journal Title: PLOS Pathogen
  • Peer Reviewed
• [Journal Article] Treatment choice of immunotherapy or further chemotherapy for Epstein-Barr virusassociatedhemophagocytic lymphohistiocytosis (2012)
  • Author(s): Shiraishi A, Ohga S, Dol T, Ishimura M, Takimoto T, Takada H, Miyamoto T, Abe Y, Hara T
  • Journal Title: Pediatr Blood Cancer
  • Peer Reviewed
• [Journal Article] 血球貪食症候群hemophoagocytis syndrome特集知っておきたい内科症候群,内科 (2012)
  • Author(s): 大賀正一
  • Volume: 109巻6号増大号
• [Journal Article] Acute liver failure as the initial manifestation of Wilson disease trigerred by human parvovirus B19 infection (2012)
  • Author(s): Shiraishi A, Hoshina T, Ihara K, Doi T, Ohga S, Hara T
  • Journal Title: Pediatr Infect Dis J Volume: 31(1) Issue: 1 Pages: 103-104
  • DOI: 10.1097/inf.0b013e31823662ee
  • Peer Reviewed
• [Journal Article] 血球貪食症候群hemophoagocytis syndrome特集知っておきたい内科症候群 (2012)
  • Author(s): 大賀正一
  • Journal Title: 内科 Volume: 109巻6号増大号(印刷中)
• [Journal Article] Clonal origin of Epstein-Barr virus(EBV) infected T/NK-cell subpopulations in EBVpositive T/NK-cell lymphoproliferative disorders of childhood (2011)
  • Author(s): Ohga S, Ishimura M, Yoshimoto G, Miyamoto T, Takada H, Tanaka T, Ohshima K, Ogawa Y, lmadome K, Abe Y, Akashi K, Hara T
  • Journal Title: J Crin viral Volume: 51(1) Pages: 31-37
  • Peer Reviewed
• [Journal Article] Potent induction of IFN-y production from cord blood NK cells by the stimulation with singlestrand RNA (2011)
  • Author(s): Eljaafari FM, Takada H, Tanaka T, Dol T, Ohga S, Hara T
  • Journal Title: J Crin Immunol Zot Volume: 31(4) Pages: 728-735
  • Peer Reviewed
• [Journal Article] Hemophagocytic lymphohistiocytosis after hematopoietic stem cell transplantation in children : a nationwide survey in Japan (2011)
  • Author(s): 柊sa no T, Kogawa K, Morimoto A, Ishida Y, Suzuki N, Ohga S, Kudo K, Ohta S, Wakiguchi H, Tabuchi K, Kate S, Ishii E
  • Journal Title: Pediatr Blood Cancer
  • Peer Reviewed
• [Journal Article] ExtensivegenedeletionsinJapanesepatientswithDiamond-Blackfan anemia (2011)
  • Author(s): KuramitsuM, MatsubaraA, MorioT, TakagiM, TokiT, TeruiK, RuNanW, KannoH, Ohga S, OharaA, KitohT, SugitaK, KudoK, MatsubayashiT, MizueN, OzekiM, MasumiA, MomoseH, TakizawaK, MizukamiT, YamaguchiK, OgawaS, ItoE, HamaguchiI
  • Journal Title: Blood
  • Peer Reviewed
• [Journal Article] Recurrentat riall fibrillation after high-dose methylprednisolone therapy in a girl with lupusassociated hemophagocytic syndrome (2011)
  • Author(s): Yamamura K, Ohga S, Nishiyama K, Doi T, Tsutsumi Y, Ikeda K, Fujishima A, Takada H, Hara T
  • Journal Title: Lupus Volume: 20(8) Pages: 871-875
  • Peer Reviewed
• [Journal Article] Serum prohepcidin concentrations at birth and one month after birth in premature infants (2011)
  • Author(s): Kitajima J, Ohga S, Kinjo T, Ochiai M, Takahata Y, Honjo S, Hara T
  • Journal Title: Pediatric Blood & Cancer Volume: 56 Pages: 267-272
  • NAID: 10026710614
  • Peer Reviewed
• [Journal Article] ウイルス感染と免疫異常 (2011)
  • Author(s): 大賀正一
  • Journal Title: IIウイルス感染と免疫障害EBウイルス、臨床とウイルス Volume: 39巻 Pages: 33-38
  • Peer Reviewed
• [Journal Article] EBウイルス感染TINK細胞リンパ増殖症～臨床病態と感染標的細胞～ (2011)
  • Author(s): 大賀正一
  • Journal Title: 福岡医学雑誌 Volume: 102巻 Pages: 41-47
  • Peer Reviewed
• [Journal Article] 血球貪食症候群の発症機構に迫る4. EBV関連血球食食症候群 (2011)
  • Author(s): 土居岳彦、大賀正一
  • Journal Title: 医学のあゆみ Volume: 238巻 Pages: 1053-1057
• [Journal Article] 血球貪食症候群の病態と治療update遺伝性血球貪食症候群の発症機序 (2011)
  • Author(s): 大賀正一
  • Journal Title: 血液内科 Volume: 63巻5号 Pages: 640-643
• [Journal Article] Clonal origin of Epstein-Barr virus (EBV)-infected T/NK-cell subpopulations in EBV-positive T/NK-cell lymphoproliferative disorders of childhood (2011)
  • Author(s): Ohga S, Ishimura M, Yoshimoto G, Miyamoto T, Takada H, Tanaka T, Ohshima K, Ogawa Y, Imadome K, Abe Y, Akashi K, Hara T
  • Journal Title: J Clin Virol Volume: 51(1) Issue: 1 Pages: 31-37
  • DOI: 10.1016/j.jcv.2011.01.014
  • Peer Reviewed
• [Journal Article] CD4^+T cells have a critical role in the proliferation of EBV-infected T and NK cells (2011)
  • Author(s): Imadome K, Yajima M, Arai A, Nakagawa-Nakazawa A, Kawano F, Ichikawa S, Shimizu N, Yamamoto N, Morio T, Ohga S, Nakamura H, Ito M, Miura O, Komano J, Fujiwara S
  • Journal Title: PLOS Pathogen Volume: (in press) Issue: 10 Pages: 1-14
  • DOI: 10.1371/journal.ppat.1002326
  • Peer Reviewed
• [Journal Article] Treatment choice of immunotherapy or further chemotherapy for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (2011)
  • Author(s): Shiraishi A, Ohga S, Doi T, Ishimura M, Takimoto T, Takada H, Miyamoto T, Abe Y, Hara T
  • Journal Title: Pediatr Blood Cancer Volume: (in press) Issue: 2 Pages: 265-270
  • DOI: 10.1002/pbc.24039
  • Peer Reviewed
• [Journal Article] Potent induction of IFN-γ production from cord blood NK cells by the stimulation with single stranded RNA (2011)
  • Author(s): Eljaafari FM, Takada H, et al
  • Journal Title: J Clin Immunol Volume: 31 Issue: 4 Pages: 728-735
  • DOI: 10.1007/s10875-011-9528-4
  • Peer Reviewed
• [Journal Article] Hemophagocytic lymphohistiocytosis after hematopoietic stem cell transplantation in children : a nationwide survey in Japan (2011)
  • Author(s): Asano T, Kogawa K, Morimoto A, Ishida Y, Suzuki N, Ohga S, Kudo K, Ohta S, Wakiguchi H, Tabuchi K, Kato S, Ishii E
  • Journal Title: Pediatr Blood Cancer Volume: (in press) Issue: 1 Pages: 110-114
  • DOI: 10.1002/pbc.23384
  • Peer Reviewed
• [Journal Article] Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia (2011)
  • Author(s): Kuramitsu M, Matsubara A, Morio T, Takagi M, Toki T, Terui K, RuNan W, Kanno H, Ohga S, Ohara A, Kitoh T, Sugita K, Kudo K, Matsubayashi T, Mizue N, Ozeki M, Masumi A, Momose H, Takizawa K, Mizukami T, Yamaguchi K, Ogawa S, Ito E, Hamaguchi I
  • Journal Title: Blood Volume: (in press) Issue: 10 Pages: 2376-84
  • DOI: 10.1182/blood-2011-07-368662
  • Peer Reviewed
• [Journal Article] Reduced-intensity conditioning in unrelated donor cord blood transplantation for patients with familial hemophagocytic lymphohistiocytosis (2011)
  • Author(s): Nishi M, Nishimura R, Suzuki N, Sawada A, Okamura T, Fujita N, Kanai R, Yano J, Adachi S, Yasumi T, Sato E, Yasutomo K, Ishii E, Ohga S
  • Journal Title: Am J Hematol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Recurrent atrial fibrillation after high-dose methylprednisolone therapy in a girl with lupus-associated hemophagocytic syndrome (2011)
  • Author(s): Yamamura K, Ohga S, Nishiyama K, Doi T, Tsutsumi Y, Ikeda K, Fujishima A, Takada H, Hara T
  • Journal Title: Lupus Volume: 20(8) Issue: 8 Pages: 871-875
  • DOI: 10.1177/0961203310392429
  • NAID: 120005133087
  • Peer Reviewed
• [Journal Article] Differential transmission and postnatal outcome in triplets with congenital cytomegalovirus infection (2011)
  • Author(s): Kitajima J, Inoue H, Ohga S, Kinjo T, Ochiai M, Yoshida T, Kusuhara K, Hara T
  • Journal Title: Pediatr Development Pathol Volume: (in press) Issue: 2 Pages: 151-155
  • DOI: 10.2350/11-05-1034-cr.1
  • Peer Reviewed
• [Journal Article] 特集「ウイルス感染と免疫異常」IIウイルス感染と免疫障害EBウイルス (2011)
  • Author(s): 大賀正一
  • Journal Title: 臨床とウイルス Volume: 39 Pages: 33-38
  • Peer Reviewed
• [Journal Article] EBウイルス感染T/NK細胞リンパ増殖症～臨床病態と感染標的細胞～ (2011)
  • Author(s): 大賀正一
  • Journal Title: 福岡医学雑誌 Volume: 102 Pages: 41-47
  • NAID: 40018873501
  • Peer Reviewed
• [Journal Article] 血球貪食症候群の発症機構に迫る4.EBV関連血球貪食症候群 (2011)
  • Author(s): 土居岳彦、大賀正一
  • Journal Title: 医学のあゆみ Volume: 238 Pages: 1053-1057
• [Journal Article] Serum prohepcidin concentrations at birth and one month after birth in premature infants. (2011)
  • Author(s): Kitajima J, Ohga S, Kinjo T, Ochiai M, Takahata Y, Honjo S, Hara T
  • Journal Title: Pediatric Blood & Cancer Volume: 56 Pages: 267-272
  • NAID: 10026710614
  • Peer Reviewed
• [Journal Article] Incomplete Kawasaki disease in a patient with chronic granulomatous disease. (2011)
  • Author(s): Muneuchi J, Ishimura M, Takada H, Hoshina T, Utsunomiya R, Ikeda K, Yamaguchi K, Ohga S, Kusuhara K, Hara T
  • Journal Title: Pediatr Int Volume: (in press)
  • Peer Reviewed
• [Journal Article] Nephrolithiasis as an extra-intestinal presentation of pediatric inflammatory bowel disease unclassified. (2011)
  • Author(s): Torio M, Ishimura M, Ohga S, Doi T, Utsunomiya R, Ohkubo K, Suga N, Tatsugami K, Matsumoto T, Takada H, Hara T
  • Journal Title: J Crohn & Colitis Volume: (in press)
  • Peer Reviewed
• [Journal Article] Recurrent atrial fibrillation after high-dose methylprednisolone therapy in a girl with lupus-associated hemophagocytic syndrome. (2011)
  • Author(s): Yamamura K, Ohga S, Nishiyama K, Doi T, Tsutsumi Y, Ikeda K, Fujishima A, Takada H, Hara T
  • Journal Title: Lupus Volume: (in press)
  • NAID: 120005133087
  • Peer Reviewed
• [Journal Article] Clonal origin of Epstein-Barr virus(EBV)-infected T/NK-cell subpopulations in EBV-positive T/NK-cell lymphoproliferative disorders of childhood. (2011)
  • Author(s): Ohga S, Ishimura M, Yoshimoto G, Miyamoto T, Takada H, Tanaka T, Ohshima K, Ogawa Y, Imadome K, Abe Y, Akashi K, Hara T
  • Journal Title: J Clin Virol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Incomplete Kawasaki disease in a patient with chronic granulomatous disease (2010)
  • Author(s): Muneuchi J, Ishimura M, Takada H, Hoshina T, Utsunomiya R, Ikeda K, Yamaguchi K, Ohga S, Kusuhara K, Hara T
  • Journal Title: Pediatr Int Volume: 52(3) Pages: 134-136
  • Peer Reviewed
• [Journal Article] Improved outcome of refractory Langerhans cell histiocytosis in children with hematopoietic stem cell transplantation in Japan (2010)
  • Author(s): Kudo K, Ohga S, Morimoto A, Ishida Y, Suzuki N, Hasegawa D, Nagatoshi Y, Kate S, Ishii E
  • Journal Title: Bone Marrow Transplant Volume: 45 Pages: 901-906
  • Peer Reviewed
• [Journal Article] Mutations in the ribosomal protein genes in Japanese patients with DiamondBlackfan anemia (2010)
  • Author(s): Konno Y, Toki T, Tandai S, Xu G, Wang R, Terui K, Ohga S, Hara T, Hama A, Kojima S, Hasegawa D, Kosaka Y, Yanagisawa R, Koike K, Kanai R, Imai T, Hongo T, Park MI, Sugita K, Ito E
  • Journal Title: Haematologica Volume: 95 Pages: 1293-1299
  • Peer Reviewed
• [Journal Article] NEMO mutation as a cause of familial occurrence of Behcet' s disease in female patients (2010)
  • Author(s): Takada H, Nomura A, Ishimura M, Ichiyama M, Ohga S, Hara T
  • Journal Title: Crin Genet Volume: 78 Pages: 575-579
  • Peer Reviewed
• [Journal Article] Hepatitisassociated aplastic anemia during a primary infection of genotype 1 a torque teno virus (2010)
  • Author(s): Ishimura M, Ohga S, Ichiyama M, Kusuhara K, Takada H, Hara T, Takahashi M, Okamoto H
  • Journal Title: Eur J Pediatr Volume: 169 Pages: 899-902
  • Peer Reviewed
• [Journal Article] Stem cell transplantation for pediatric malignancy Hemophagocytic lymphohistiocytosis (2010)
  • Author(s): Ohga S, Ishii E, Takada H, Hara T
  • Journal Title: 15th Congress of AsiaPacific Blood and Marrow Transplantation Pages: 71-76
• [Journal Article] Nationwide survey of singlesystem single site Langerhans cell histiocytosis in Japan (2010)
  • Author(s): Morimoto A, Ishida Y, Suzuki N, Ohga S, Shioda Y, Okimoto Y, Kudo K, Ishii E
  • Journal Title: Pediatric Blood Cancer Volume: 54(1) Pages: 98-102
  • Peer Reviewed
• [Journal Article] Hematopoietic stem cell transplantation for familial hemophagocytic lymphohistiocytosis and Epstein-Barr virusassociated hemophagocytic lymphohistiocytosis in Japan (2010)
  • Author(s): Ohga S, Kudo K, Ishii E, Honjo S, Morimoto A, Osugi Y, Sawada A, Tabuchi T, Suzuki N, Ishida Y, Imashuku S, Kate S, Hara T
  • Journal Title: Pediatric Blood Cancer Volume: 54(2) Pages: 299-306
  • Peer Reviewed
• [Journal Article] 成人EBウイルス関連血球貪食症候群5例の検討 (2010)
  • Author(s): 安部康信、白土基明、永澤恵理子、大塚理恵、喜安純一、佐田絵里子、井筒挙策、古藤和浩、西村純二、大賀正一、高柳涼一
  • Journal Title: 臨床血液 Volume: 51巻 Pages: 74-79
  • NAID: 10026332146
  • Peer Reviewed
• [Journal Article] 特集企画血液疾患の診かた一血液専門医以外のための血液疾患対応マニュアルー血球貧食症候群 (2010)
  • Author(s): 大賀正一
  • Journal Title: プライマリ・ケア医のための総合誌「治療」 Volume: 92巻 Pages: 2401-2406
• [Journal Article] Nationwide survey of single-system single site Langerhans cellhistiocytosis in Japan. (2010)
  • Author(s): Morimoto A, Ishida Y, Suzuki N, Ohga S, Shioda Y, Okimoto Y, Kudo K, Ishii E
  • Journal Title: Pediatric Blood & Cancer Volume: 54 Pages: 98-102
  • Peer Reviewed
• [Journal Article] Hematopoietic stem cell transplantation for familial hemophagocytic lymphohistiocytosis and Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in Japan. (2010)
  • Author(s): Ohga S, Kudo K, Ishii E, Honjo S, Morimoto A, Osugi Y, Sawada A, Tabuchi T, Suzuki N, Ishida Y, Imashuku S, Kato S, Hara T, for The HLH/LCH, SCT Committees in the Japanese Society of Pediatric Hematology
  • Journal Title: Pediatric Blood & Cancer Volume: 54 Pages: 299-306
  • Peer Reviewed
• [Journal Article] Improved outcome of refractory Langerhans cell histiocytosis in children with hematopoietic stem cell transplantation in Japan. (2010)
  • Author(s): Kudo K, Ohga S, Morimoto A, Ishida Y, Suzuki N, Hasegawa D, Nagatoshi Y, Kato S, Ishii E
  • Journal Title: Bone Marrow Transplant Volume: 45 Pages: 901-906
  • Peer Reviewed
• [Journal Article] Mutations in the ribosomal protein genes in Japanese patients with Diamond-Blackfan anemia. (2010)
  • Author(s): Konno Y, Toki T, Tandai S, Xu G, Wang R, Terui K, Ohga S, Hara T, Hama A, Kojima S, Hasegawa D, Kosaka Y, Yanagisawa R, Koike K, Kanai R, Imai T, Hongo T, Park MJ, Sugita K, Ito E
  • Journal Title: Haematologica Volume: 95 Pages: 1293-1299
  • Peer Reviewed
• [Journal Article] NEMO mutation as a cause of familial occurrence of Behcet's disease in female patients. (2010)
  • Author(s): Takada H, Nomura A, Ishimura M, Ichiyama M, Ohga S, Hara T
  • Journal Title: Clin Genet Volume: 78 Pages: 575-579
  • Peer Reviewed
• [Journal Article] Hepatitis-associated aplastic anemia during a primary infection of genotype 1a torque teno virus. (2010)
  • Author(s): Ishimura M, Ohga S, Ichiyama M, Kusuhara K, Takada H, Hara T, Takahashi M, Okamoto H
  • Journal Title: Eur J Pediatr Volume: 169 Pages: 899-902
  • Peer Reviewed
• [Journal Article] Stem cell transplantation for pediatric malignancy Hemophagocytic lymphohistiocytosis. (2010)
  • Author(s): Ohga S, Ishii E, Takada H, Hara T
  • Journal Title: 15th Congress of Asia-Pacific Blood and Marrow Transplantation Volume: Education Pages: 71-76
• [Journal Article] 特集企画血液疾患の診かた-血液専門医以外のための血液疾患対応マニュアル-血球貪食症候群 (2010)
  • Author(s): 大賀正一
  • Journal Title: プライマリ・ケア医のための総合誌「治療」 Volume: 92 Pages: 2401-2406
• [Journal Article] 14.免疫疾患慢性活動性EBウイルス感染症 (2010)
  • Author(s): 土居岳彦、大賀正一、原寿郎
  • Journal Title: 総合小児科診療のための小児科学レビュー2010 Pages: 184-190
• [Journal Article] Nationwide survey of single-system single site Langerhans cell histiocytosis in Japan (2010)
  • Author(s): Morimoto A, Ishida Y, Suzuki N, Ohga S, Shioda Y, Okimoto Y, Kudo K, Ishii E
  • Journal Title: Pediatric Blood Cancer 54(1) Pages: 98-102
  • Peer Reviewed
• [Journal Article] Hematopoietic stem cell transplantation for familial hemophagocytic lymphohistiocytosis and Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in Japan (2010)
  • Author(s): Ohga S, Kudo K, Ishii E, Honjo S, Morimoto A, Osugi Y, Sawada A, Tabuchi T, Suzuki N, Ishida Y, Imashuku S, Kato S, Hara T
  • Journal Title: Pediatric Blood Cancer 54(2) Pages: 299-306
  • Peer Reviewed
• [Journal Article] Improved outcome of refractory Langerhans cell histiocytosis in children with allogeneic stem cell transplantation in Japan (2010)
  • Author(s): Kudo K, Ohga S, Morimoto A, Ishida Y, Suzuki N, Hasegawa D, Nagatoshi Y, Kato S, Ishii E
  • Journal Title: Bone Marrow Transplant (in press)
  • Peer Reviewed
• [Journal Article] Incomplete Kawasaki disease in a patient with chronic granulomatous disease (2010)
  • Author(s): Muneuchi J, Ishimura M, Takada H, Hoshina T, Utsunomiya R, Ikeda K, Yamaguchi K, Ohga S, Kusuhara K, Hara T
  • Journal Title: Pediatr Int (in press)
  • Peer Reviewed
• [Journal Article] Hepatitis-associated aplastic anemia during a primary infection of genotype 1a torque teno virus (2010)
  • Author(s): Ishimura M, Ohga S, Ichiyama M, Kusuhara K, Takada H, Hara T, Takahashi M, Okamoto H
  • Journal Title: Eur J Pediatr (in press)
  • Peer Reviewed
• [Journal Article] Mutations in the ribosomal protein genes in Japanese patients with Diamond-Blackfan Anemia (2010)
  • Author(s): Konno Y, Toki T, Tandai S, Xu G, Wang RN, Terui K, Ohga S, Hara T, Hama A, Kojima S, Hasegawa D, Kosaka Y, Yanagisawa R, Koike K, Kanai R, Imai T, Hongo T, Park M-J, Sugita K, Ito E
  • Journal Title: Haematologica (in press)
  • Peer Reviewed
• [Journal Article] 慢性活動性EBウイルス感染症 (2010)
  • Author(s): 土居岳彦, 大賀正一, 原寿郎
  • Journal Title: 総合小児科診療のための小児科学レビュー (印刷中)
• [Journal Article] Fulminant sepsis/meningitis due to Haemophilus influenzae in a protein Cdeficient heterozygote treated with activated protein C therapy (2009)
  • Author(s): Ishimura M, Saito M, Ohga S, Hoshina T, Baba H, Urata M, Kira R, Takada H, Kusuhara K, Kang D, Hara T
  • Journal Title: Eur J Pediatr Volume: 168(6) Pages: 673-677
  • Peer Reviewed
• [Journal Article] Cardiovascular complications associated with chronic active Epstein-Barr virus infection (2009)
  • Author(s): Muneuchi J, Ohga S, Ishimura M, Ikeda K, Yamaguchi K, Nomura A, Takada H, Abe Y, Hara T
  • Journal Title: Pediatr Cardiol Volume: 30(3) Pages: 274-281
  • Peer Reviewed
• [Journal Article] Characteristicsofhemophagocyticlymphohistiocytosisinneonates:anationwidesurveyinJapan (2009)
  • Author(s): SuzukiN, MorimotoA, Ohga S, KudoK, IshidaYlIshii E
  • Journal Title: JPediatr Volume: 155(2) Pages: 235-238
  • Peer Reviewed
• [Journal Article] Neonatal onset hemophagocytic lymphohistiocytosis in a premature infant (2009)
  • Author(s): KatsuragiS, Ohga S, HoriuchiH, HaraT, TeraoK, IkedaT
  • Journal Title: Pediatr Blood Cancer Volume: 53(2) Pages: 244-245
  • Peer Reviewed
• [Journal Article] 免疫不全症候群と遺伝子異常各疾患の遺伝子異常,診断と治療家族性血球貧食症候群 (2009)
  • Author(s): 大賀正一、田中珠美
  • Journal Title: 臨床検査 Volume: 53巻 Pages: 599-604
• [Journal Article] 小児疾患診療のための病態生理血液・腫瘍性疾患血球貪食症候群 (2009)
  • Author(s): 大賀正一
  • Journal Title: 小児内科増刊号 Volume: 41巻 Pages: 1197-1202
• [Journal Article] Fulminant sepsis/meningitis due to Haemophilus influenzae in a protein C-deficient heterozygote treated with activated protein C therapy (2009)
  • Author(s): Ishimura M, Saito M, Ohga S, Hoshina T, Baba H, Urata M, Kira R, Takada H, Kusuhara K, Kang D, Hara T
  • Journal Title: Eur J Pediatr 168(6) Pages: 673-677
  • Peer Reviewed
• [Journal Article] Cardiovascular complications associated with chronic active Epstein-Barr virus infection (2009)
  • Author(s): Muneuchi J, Ohga S, Ishimura M, Ikeda K, Yamaguchi K, Nomura A, Takada H, Abe Y, Hara T
  • Journal Title: Pediatr Cardiol 30(3) Pages: 274-281
  • Peer Reviewed
• [Journal Article] Characteristics of hemophagocytic lymphohistiocytosis in neonates : anationwide survey in Japan (2009)
  • Author(s): Suzuki N, Morimoto A, Ohga S, Kudo K, Ishida Y, Ishii E
  • Journal Title: J Pediatr 155(2) Pages: 235-238
  • Peer Reviewed
• [Journal Article] Disseminated Bacillus Calmette-Guerin lymphadenitis in a patient with gp91phox- chronic granulomatous disease 25 years after vaccination (2009)
  • Author(s): Kusuhara K, Ohga S, Hoshina T, Saito M, Sasaki Y, Ishimura M, Takada H, Fujita M, Hara T
  • Journal Title: Eur J Pediatr 168(6) Pages: 745-747
  • Peer Reviewed
• [Journal Article] Neonatal onset hemophagocytic lymphohistiocytosis in a premature infant (2009)
  • Author(s): Katsuragi S, Ohga S, Horiuchi H, Hara T, Terao K, Ikeda T
  • Journal Title: Pediatr Blood Cancer 53(2) Pages: 244-245
  • Peer Reviewed
• [Journal Article] 免疫不全症候群と遺伝子異常 各疾患の遺伝子異常, 診断と治療家族性血球貪食症候群 (2009)
  • Author(s): 大賀正一, 田中珠美
  • Journal Title: 臨床検査 53 Pages: 599-604
• [Journal Article] 小児疾患診療のための病態生理 血液・腫瘍性疾患 血球貪食症候群 (2009)
  • Author(s): 大賀正一
  • Journal Title: 小児内科 増刊号 41 Pages: 1197-1202
• [Presentation] コクサッキーウイルスB1の垂直感染により全身感染症を発症し、血球貪食症候群を合併した新生児例 (2011)
  • Author(s): 深澤光晴、名西悦郎、西尾壽乗、保科隆之、土居岳彦、原寿郎、大賀正一
  • Organizer: 第467回日本小児科学会福岡地方会例会
  • Place of Presentation: 福岡
  • Year and Date: 2011-12-10
• [Presentation] 血球貪食症候群に対する治療戦略 (2011)
  • Author(s): 大賀正一
  • Organizer: 第62回日本小児科学会佐賀地方会(招待講演)
  • Place of Presentation: 佐賀
  • Year and Date: 2011-12-03
• [Presentation] 血球貪食症候群に対する治療戦略 (2011)
  • Author(s): 大賀正一
  • Organizer: 第62回日本小児科学会佐賀地方会
  • Place of Presentation: 佐賀(招待講演)
  • Year and Date: 2011-12-03
• [Presentation] 小児先天性Protein C欠乏症の発症様式 (2011)
  • Author(s): 大賀正一、金城唯宗、落合正行、松永友佳、石村匡崇、土居岳彦、井藤奈央子、山本順子、康東天、原寿郎
  • Organizer: 第1回日本血液学会九州地方会教育セミナー
  • Place of Presentation: 福岡(招待講演)
  • Year and Date: 2011-09-03
• [Presentation] Diagnostic usefulness of the expression levels of interferonstimulated genes in histiocytic necrotizing lymphadenitis (2011)
  • Author(s): shimura M, Mizuno Y, Takada H, Doi T, Ohga S, Hara T
  • Organizer: M 40回日本免疫学会学術集会
  • Place of Presentation: 千葉
• [Presentation] 家族性血球貧食性リンパ組織球症(FHL)に対する前処置軽減非血縁膀帯血移植(RIC-UCBT)' (2011)
  • Author(s): 西眞範、西村良成、鈴木信寛、岡村隆行、矢野潤、足立壮一、八角高裕、佐藤恵実子、金井理恵、藤田直人、澤田明久、石井榮一、大賀正一
  • Organizer: 第53回日本小児血液・がん学会学術集会2011
  • Place of Presentation: 前橋
• [Presentation] EBウイルス関連血球貧食性リンパ組織球症(EBV」HLH)の治療選択:単一施設の解析から (2011)
  • Author(s): 白石暁、土居岳彦、大賀正一、石村匡崇、瀧本智仁、高田英俊、宮本敏浩、安部康信、原寿郎
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
• [Presentation] Unrelated cord Blood Transplantation for familial hemophagocytic lymphohistiocytosis(FHL) (2011)
  • Author(s): Ohga S, Nishi M, Nishimura R, Suzuki N, Okamura T, Yano J, Adachi S, Sato E, Kanai R, Sawada A, Ishii E
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] Characteristic presentation of congenital protein C(PC) deficiency in childR) od (2011)
  • Author(s): Ohga S, Kinjo T, Matsunaga Y, Ochiai M, Doi T, Ishimura M, Yamamoto Y, Suenobu S, Shirahata A, Urata M, Kayamori Y, Kang D, Hara T
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] Treatment outcomes of EB virusassociatedhemophagocytic lymphohistiocytosis in a single institution (2011)
  • Author(s): Shiraishi A, Doi T, Ohga S, Ishimura M, Takimoto T, Takada H, Miyamoto T, Abe Y, Hara T
  • Organizer: 73回日本血液学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] High levels of human cytokines were detected in a novel mouse xenograft model of CAEBV and EBV-HLH' (2011)
  • Author(s): Yamada C, Imadome K, Arai A, Nakazawa A, Kawano F, Ichikawa S, Shimizu N, Yamamoto N, Morio T, Ohga S, Ito M, Koyama T, Miura 0, Komano J, Fujiwara S
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] 慢性活動性EBウイルス感染症におけるEBV感染T/NK細胞クローンの起源 (2011)
  • Author(s): 大賀正一、石村匡崇、土居岳彦、瀧本智仁、高田英俊、原寿郎
  • Organizer: 第114回日本小児科学会学術集会2011
  • Place of Presentation: 東京
• [Presentation] Congenital protein C deficiency in the Japanese experience The 7th Congress of ASPR, Hematology Session" Thrombosis in Children in the West and East" (2011)
  • Author(s): Ohga S
  • Organizer: Pediatric Academic Societies(PAS) and Asian Society for Pediatric Research(ASPR) 2011 Joint Meeting
  • Place of Presentation: Colorado, USA
• [Presentation] Congenital protein C deficiency in the Japanese experience The 7th Congress of ASPR, Hematology Session "Thrombosis in Children in the West and East" (2011)
  • Author(s): Ohga S
  • Organizer: Pediatric Academic Societies (PAS) and Asian Society for Pediatric Research (ASPR) 2011 Joint Meeting
  • Place of Presentation: Denver, Colorado, USA(招待講演)
• [Presentation] Serum prohepcidin levels during the neonatal period of term and preterm newborns (2011)
  • Author(s): Kitajima J, Ohga S, Kinjo T, Ochiai M,Takahata Y, Honjo S, Hara T
  • Organizer: Pediatric Academic Societies (PAS) and Asian Society for Pediatric Research (ASPR) 2011 Joint Meeting
  • Place of Presentation: Denver, Colorado, USA
• [Presentation] Prophylaxis in Hemophilia～Experience in Japan～ (2011)
  • Author(s): Ohga S
  • Organizer: The 4th Congress of East Asia, Hemophilia Forum (EAHF)
  • Place of Presentation: Tianjin, Mainland China(招待講演)
• [Presentation] 慢性活動性EBウイルス感染症におけるEBV感染T/NK細胞クローンの起源 (2011)
  • Author(s): 大賀正一、石村匡崇、土居岳彦、瀧本智仁、高田英俊、原寿郎
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: 東京
• [Presentation] EBウイルス関連血球貪食症候群22例の後方視的検討 (2011)
  • Author(s): 白石暁、土居岳彦、大賀正一、石村匡崇、瀧本智仁、高田英俊、宮本敏浩、安部康信、原寿郎
  • Organizer: 第39回日本臨床免疫学会総会
  • Place of Presentation: 東京
• [Presentation] Characteristic presentation of congenital protein C (PC) deficiency in childfood (2011)
  • Author(s): Ohga S, Kinjo T, Matsunaga Y, Ochiai M, Doi T, Ishimura M, Yamamoto Y, Suenobu S, Shirahata A, Urata M, Kayamori Y, Kang D, Hara T
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] Treatment outcomes of EB virus-assosiated hemophagocytic lymphohistiocytosis in a single institution (2011)
  • Author(s): Shiraishi A, Doi T, Ohga S, Ishimura M, Takimoto T, Takada H, Miyamoto T, Abe Y, Hara T
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] High levels of human cytokines were detected in a novel mouse xenograft model of CAEBV and EBV-HLH (2011)
  • Author(s): Yamada C, Imadome K, Arai A, Nakazawa A, Kawano F, Ichikawa S, Shimizu N, Yamamoto N, Morio T, Ohga S, Ito M, Koyama T, Miura O, Komano J, Fujiwara S
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] 家族性血球貪食性リンパ組織球症(FHL)に対する前処置軽減非血縁臍帯血移植(RIC-UCBT) (2011)
  • Author(s): 西眞範、西村良成、鈴木信寛、岡村隆行、矢野潤、足立壮一、八角高裕、佐藤恵実子、金金井理恵、藤田直人、澤田明久、石井榮一、大賀正一
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
• [Presentation] 日本におけるChediak-Higashi症候群の疫学とその臨床像 (2011)
  • Author(s): 石井榮一、鈴木信寛、前田美穂、石田也寸志、金兼弘和、岡村隆行、鬼頭敏幸、太田茂、森本哲、浅野健、大賀正一、脇口宏、永井功造
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
• [Presentation] EBウイルス関連血球貪食性リンパ組織球症(EBV-HLH)の治療選択:単一施設の解析から (2011)
  • Author(s): 白石暁、土居岳彦、大賀正一、石村匡崇、瀧本智仁、高田英俊、宮本敏浩、安部康信、原寿郎
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
• [Presentation] Diagnostic usefulness of the expression levels of interferon-stimulated genes in histiocytic necrotizing lymphadenitis (2011)
  • Author(s): Ishimura M, Mizuno Y, Takada H, Doi T, Ohga S, Hara T
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉
• [Presentation] Clonal origin of EBVinfected T/NK-cell subpopulations in chronicactive Epstein-Barr virus infection (2010)
  • Author(s): Ohga S, Takada H, Abe Y, Miyamoto T, Akashi K, Ohshima K, Hara T
  • Organizer: The 6th Workshop of Asian Hematology in Bangkok NRCT-JSPS Asian Core Program
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2010-12-23
• [Presentation] Clonal origin of EBV-infected T/NK-cell subpopulations in chronicactive Epstein-Barr virus infection. (2010)
  • Author(s): Ohga S, Takada H, Abe Y, Miyamoto T, Akashi K, Ohshima K, Hara T
  • Organizer: The 6th Workshop of Asian Hematology in Bangkok NRCT-JSPS Asian Core Program
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2010-12-23
• [Presentation] 難治性EBウイルス関連疾患とその周辺 (2010)
  • Author(s): 大賀正一
  • Organizer: 第3回札幌小児血液疾患勉強会
  • Place of Presentation: 札幌
  • Year and Date: 2010-11-26
• [Presentation] 難治性EBウイルス関連疾患-その診断と治療 (2010)
  • Author(s): 大賀正一
  • Organizer: 第17回福岡血液研究会
  • Place of Presentation: 福岡
  • Year and Date: 2010-11-12
• [Presentation] Hematopoietic stem cell transplantation for HLH/LCH, and a review of neonatal hemophagocytic lymphohistiocytosis in Japan (2010)
  • Author(s): Ohga S
  • Organizer: The 4th Seminar on Histiocytosis & Pediatric MDS(招待講演)
  • Place of Presentation: Korea
  • Year and Date: 2010-10-07
• [Presentation] Hematopoietic stem cell transplantation. for HLH/LCH, and a review of neonatal HLH in Japan. (2010)
  • Author(s): Ohga S
  • Organizer: The 4th Seminar on Histiocytosis & Pediatric MDS
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-10-07
• [Presentation] Clonal origin of EB virusinfected T/NK-cells in chronic active EB virus infection (2010)
  • Author(s): Ohga S, Ishimura M, Doi T, Takada H, Yoshimoto G, Miyamoto T, Abe Y, Imadome K, Ohshima K, Akashi K, Hara T
  • Organizer: 横浜第72回日本血液学会
  • Year and Date: 2010-09-25
• [Presentation] Four adult cases of chronic active Epstein-Barr virus(EBV) infection (2010)
  • Author(s): Abe Y, Shiratsuchi M, Nagasawa E, Ohno H, Sada E, Ohba R, Matsushima T, Ohga S, Takayanagi R, Ohshima K
  • Organizer: 第72回日本血液学会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25
• [Presentation] Hemophagocytic lymphohistiocytosis after stem cell transplantation in children : nationwide survey (2010)
  • Author(s): Asano T, Kogawa K, Morimoto A, Ishida Y, Suzuki N, Ohga S, Kudoh K, Ohta S. Wakiguchi H, Tabuchi K, Katoh S, Ishii E
  • Organizer: 第72回日本血液学会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25
• [Presentation] Clonal origin of EB virus-infected T/NK-cells in chronic active EB virus infection. (2010)
  • Author(s): Ohga S, Ishimura M, Doi T, Takada H, Yoshimoto G, Miyamoto T, Abe Y, Imadome K, Ohshima K, Akashi K, Hara T
  • Organizer: 第72回日本血液学会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25
• [Presentation] Four adult cases of chronic active Epstein-Barr virus(EBV)infection. (2010)
  • Author(s): Abe Y, Shiratsuchi M, Nagasawa E, Ohno H, Sada E, Ohba R, Matsushima T,Ohga S, Takayanagi R, Ohshima K
  • Organizer: 第72回日本血液学会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25
• [Presentation] Hemophagocytic lymphohistiocytosis after stem cell transplantation in children : nationwide survey. (2010)
  • Author(s): Asano T, Kogawa K, Morimoto A, Ishida Y, Suzuki N, Ohga S, Kudoh K, Ohta S, Wakiguchi H, Tabuchi K, Katoh S, Ishii E
  • Organizer: 第72回日本血液学会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25
• [Presentation] Hemophagocytic lymphohistiocytosis. Education Session IV Hematopoietic stem cell transplantation for pediatric malignant diseases (2010)
  • Author(s): Ohga S
  • Organizer: The 15th Congress of AsiaPacific BMT(招待講演)
  • Place of Presentation: Phuket
• [Presentation] hemophagocytic lymphohistiocytosis after hematopoietic stem cell transplantation in children : nationwide survey of Japan (2010)
  • Author(s): Asano T, Kogawa K, Morimoto A, Ishida Y, Suzuki N, Ohga S, Kudo K, Ohta S, Wakiguchi H, Tabuchi K, Kato S, Ishii E, The HLH/LCH and SCT committees in the Japanese Society of Pediatric Hematology
  • Organizer: The 27th Annual Meeting of Histiocyet Society
  • Place of Presentation: Boston, USA
• [Presentation] Hemophagocytic lymphohistiocytosis. Education Session IV-HSCT for pediatric malignant diseases. (2010)
  • Author(s): Ohga S
  • Organizer: The 15th Congress of Asia-Pacific Blood and Marrow Transplantation
  • Place of Presentation: Phuket, Thailand
• [Presentation] Hemophagocytic lymphohistiocytosis after hematopoietic stem cell transplantation in children : nationwide survey of Japan. (2010)
  • Author(s): Asano T, Kogawa K, Morimoto A, Ishida Y, Suzuki N, Ohga S, Kudo K, Ohta S, Wakiguchi H, Tabuchi K, Kato S, Ishii E, The HLH/LCH, SCT committees in the Japanese Society of Pediatric Hematology
  • Organizer: The 27th Annual Meeting of Histiocyet Society
  • Place of Presentation: Boston, USA.
• [Presentation] 慢性活動性EBウイルス感染症における感染細胞の起源に関して (2010)
  • Author(s): 大賀正一、石村匡崇、土居岳彦、高田英俊、原寿郎
  • Organizer: 第52回日本小児血液学会
  • Place of Presentation: 大阪
• [Presentation] 重症新生児仮死で出生し、出生に発症した血球貪食症候群の1例 (2009)
  • Author(s): 秋原美華, 松本隼人, 福田美和子, 白川嘉継, 大賀正一
  • Organizer: 第455回日本小児科学会福岡地方会
  • Place of Presentation: 福岡
  • Year and Date: 2009-06-27
• [Presentation] EBV関連および家族性血球貪食性リンパ組織球症に対する造血細胞移植の成績 (2009)
  • Author(s): 大賀正一、工藤寿子、森本哲、大杉夕子、澤田明久、田淵健、本荘哲、原寿郎、加藤俊一、石井榮一
  • Organizer: 第112回日本小児科学会
  • Place of Presentation: 奈良
• [Presentation] EBV関連および族性血球貪食性リンパ組織球症に対する造血胞移植の成績 (2009)
  • Author(s): 大賀正一, 工藤寿子, 森本哲, 大杉夕子, 澤田明久, 田淵健, 本荘哲, 原寿郎, 加藤俊一, 石井榮一
  • Organizer: 第112回日本小児科学会
  • Place of Presentation: 奈良
• [Presentation] 小児EBV関連および家族性血球貪食性リンパ組織球症に対する造血幹細胞移植 (2009)
  • Author(s): 大賀正一, 工藤寿子, 森本哲, 大杉夕子, 澤田明久, 井上雅美, 田淵健, 鈴木信寛, 石田也寸志, 本荘哲, 原寿郎, 今宿晋作, 加藤俊一, 石井榮一
  • Organizer: 第71回日本血液学会
  • Place of Presentation: 京都
• [Presentation] 日本における家族性血球貪食性リンパ組織球症の実態とその様性 (2009)
  • Author(s): 永井巧造, 越智俊元, 末盛浩一朗, 藤原弘, 本田美里, 田内久道, 森本哲, 大賀正一, 石井榮一
  • Organizer: 第71回日本血液学会
  • Place of Presentation: 京都
• [Presentation] 日本における小児EBV-HLHの全国調査 (2009)
  • Author(s): 子川和宏, 佐藤弘樹, 浅野健, 大賀正一, 工藤寿子, 森本哲, 佐藤貴, 太田茂, 脇口宏, 金兼弘和, 小田慈, 石井榮一
  • Organizer: 第71回日本血液学会
  • Place of Presentation: 京都
• [Presentation] 日本における小児EBV-HLHの全国調査 (2009)
  • Author(s): 子川和宏, 佐藤弘樹, 浅野健, 大賀正一, 工藤寿子, 森本哲, 佐藤貴, 太田茂, 脇口宏, 金兼弘和, 小田慈, 石井榮一
  • Organizer: 第51回日本小児血液学会・第25回日本小児がん学会
  • Place of Presentation: 東京
• [Presentation] SLE患者で著明よ血小板貪食像を呈した血球貪食症候群の1症例 (2009)
  • Author(s): 藤島章義, 須田正洋, 増本道子, 佐藤薫, 大賀正一, 栢森裕三, 康東天
  • Organizer: 第10回日本検査血液学会
  • Place of Presentation: 山梨
• [Book] 診断と治療社、小児の発熱AtoZ-診断 治療のTipsとPit魚lls-52.慢性活動性EBウイルス感染症 (2012)
  • Author(s): 大賀正一
  • Publisher: CAEBV(印刷中)
• [Book] 小児の発熱A to Z-診断・治療のTipsとPitfalls-52.慢性活動性EBウイルス感染症(CAEBV) (2012)
  • Author(s): 大賀正一
  • Publisher: 診断と治療社
• [Book] 免疫疾患慢性活動性EBウイルス感染症、総合小児科診療のための小児科学レビュー (2010)
  • Author(s): 土居岳彦、大賀正一、原寿郎