A study of avidity of Haemophilus influenzae type b (Hib)antibody and multiple copies of capsulation loci in the strains as possible factors of Hib vaccine failure in Japan.
| Project/Area Number |
21591390
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tohoku University (2010-2011)
Kagoshima University (2009) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHI Junichiro 鹿児島大学, 医学部・歯学部付属病院, 講師 (40295241)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ヒブワクチン / vaccine failure / Hib莢膜遺伝子capb領域の重複 / Hib抗体のavidity低下 |
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| Research Abstract |
Haemophilus influenzae type b (Hib)occasionally causes invasive bacterial diseases such as meningitis especially among young children. In recent years, vaccine failure associated with multiple amplification of the capsulation(capb)locus has been increasingly reported in Europe. We examined Hib strains from Japanese children with Hib meningitis and founded that the proportion of strains with three or four copies of the capb locus already exist before the popularization of Hib vaccination.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Quantitative analysis of biofilm formation of methicillin-resistant Staphylococcus aureus(MRSA)strains from patients with orthopaedic device-related infections2011
Author(s)
Kawamura H, Nishi J, Imuta N, Tokuda K, Miyanohara H, Hashiguchi T, Zenmyo M, Yamamoto T, Ijiri K, Kawano Y, and Komiya S
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Journal Title
FEMS Immunology & Medical Microbiology
Volume: 63
Pages: 10-15
Related Report
Peer Reviewed
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[Journal Article] Quantitative analysis of biofilm formation of methicillin-resistant Staphylococcus aureus (MESA) strains from patients with orthopaedic device-related infections2011
Author(s)
Kawamura H, Nishi J, Imuta N, Tokuda K, Miyanohara H, Hashiguchi T, Zenmyo M, Yamamoto T, Ijiri K, Kawano Y, Komiya S
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Journal Title
FEMS Immunology & Medical Microbiology
Volume: 63
Issue: 1
Pages: 10-15
DOI
Related Report
Peer Reviewed
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