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Elucidation of mediators which exert anti-respiratory syncytial virus activity reacted by double-stranded RNA

Research Project

Project/Area Number 21591391
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionSapporo Medical University

Principal Investigator

NAGAI Kazushige  札幌医科大学, 医学部, 研究員 (50347168)

Co-Investigator(Kenkyū-buntansha) TSUTSUMI Hiroyuki  札幌医科大学, 医学部, 教授 (80217348)
OIKAWA Takumi  札幌医科大学, 医学部, 研究員 (70574739)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
KeywordsRSウイルス / 2本鎖RNA / TLR3 / 自然免疫 / 抗ウイルス作用 / インターフェロン / poly I:C / Toll様受容体 / 抗ウイルス
Research Abstract

To investigate antiviral role of double-stranded(ds) RNA, Toll-like receptor 3(TLR3) whose ligand is dsRNA was overexpressed in A549 cells and those cells were infected with human respiratory syncytial virus(RSV). The TLR3-overexpressed cells produced significantly less amount of RSV in a cell culture supernatant comparing to the control cells. Further investigation suggested that interferon-. was less involved in this effect.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (4 results)

All 2010 2009

All Journal Article (1 results) Presentation (3 results)

  • [Journal Article] RSウイルス感染症2010

    • Author(s)
      永井和重
    • Journal Title

      チャイルドヘルス

      Volume: 13巻 Pages: 788-791

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] ヒトTLR3過剰発現細胞クローンの樹立とRSウイルス感染に対する感染抑制効果2009

    • Author(s)
      渡辺一人
    • Organizer
      第41回日本小児感染症学会総会・学術集会
    • Place of Presentation
      福井市
    • Year and Date
      2009-11-15
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] ヒトTLR3過剰発現細胞クローンの樹立とRSウイルス感染に対する感染抑制効果2009

    • Author(s)
      渡辺一人
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2009-10-27
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] RSウイルス感染に対するTLR3の感染防御作用2009

    • Author(s)
      渡辺一人
    • Organizer
      第112回日本小児科学会学術集会
    • Place of Presentation
      奈良市
    • Year and Date
      2009-04-17
    • Related Report
      2011 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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