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Genetic variability of human cytomegalovirus UL97 gene which associated with resistance to ganciclovir

Research Project

Project/Area Number 21591392
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionSapporo Medical University

Principal Investigator

TSUTSUMI Hiroyuki  札幌医科大学, 医学部, 教授 (80217348)

Co-Investigator(Kenkyū-buntansha) YOTO Yuko  札幌医科大学, 医学部, 講師 (10404659)
HORI Tsukasa  札幌医科大学, 医学部, 助教 (20398324)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywordsヒトサイトメガロウイルス / UL97遺伝子 / ガンシクロビル / CMV / 分子疫学 / UL97 / 免疫不全 / サイトメガロウイルス
Research Abstract

UL97 codons 439 to 645 from 61 CMV isolates from 61 immunocompetent Japanese infants and children were sequenced directly. No known GCV resistance mutations were found, meaning that the UL97 mutation had resulted from the use of GCV. On the other hand, a mutation at codon 605(D to E) was frequently identified(56/61 : 91. 8%). This could be a genetic marker for HCMV in East Asian counties, because of its low prevalence in the strains of HCMV circulating in Western countries.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (9 results)

All 2012 2011 2010

All Journal Article (9 results) (of which Peer Reviewed: 9 results)

  • [Journal Article] Phylogenetic and computational structural analysis of VP7 gene of group a human rotavirus G1P[8] strains obtained in Sapporo2012

    • Author(s)
      Nagaoka Y, Tatsumi M, Tsugawa T, Yoto Y, Tsutsumi H
    • Journal Title

      J Med Virol

      Volume: 84 Pages: 832-838

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phylogenetic and computational structural analysis of VP7 gene of group a human rotavirus G1P[8] strains obtained in Sapporo, Japan from 1987-to 20002012

    • Author(s)
      Nagakoka Y, Tatsumi M, et al
    • Journal Title

      J Med Virol

      Volume: 84 Issue: 5 Pages: 832-838

    • DOI

      10.1002/jmv.23247

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human cytomegalovirus UL97 D605E polymorphism has a high prevalence in immunocompetent Japanese infants and children2011

    • Author(s)
      Tanaka K, Hori T, Yoto Y, Hatakeyama N, Yamamoto M, Suzuki N, Tsutsumi H
    • Journal Title

      Microbiol Immunol

      Volume: 55 Pages: 328-330

    • NAID

      10031121474

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human cytomegalovirus UL97 D605E polymorphism has a high prevalenee in immunocompetent Japanese infants and children2011

    • Author(s)
      Tanaka K, Hori T, et al
    • Journal Title

      Microbiol Immunol

      Volume: 55 Issue: 5 Pages: 328-330

    • DOI

      10.1111/j.1348-0421.2011.00327.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Full sequence analysis of the original Sapporo virus2011

    • Author(s)
      Nakanishi K, Tatsumi M, et al
    • Journal Title

      Microbiol Immunol

      Volume: 55 Pages: 657-660

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics and computed tomography findings in children with 2009 pandemic influenza A (H1N1) viral pneumonia2011

    • Author(s)
      Mori T, Morii M, et al
    • Journal Title

      Scand J Infect Dis

      Volume: 43 Issue: 1 Pages: 47-54

    • DOI

      10.3109/00365548.2010.515607

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristsics and computed tomography findings in children with 2009 pandemic influenza A(H1N1) viral pneumonia.2011

    • Author(s)
      Mori T, Morii M, Terada K, et al.
    • Journal Title

      Scand J Infect Dis

      Volume: 43 Pages: 47-54

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Axillaly cellulitis as a manifestation of Kawasaki disease.2010

    • Author(s)
      Kuroiwa Y, Oyanagi R, et al.
    • Journal Title

      Peditr Int

      Volume: 52 Pages: 4-5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful treatment of refractory Langerhans cell histiocytosis with pulmonary aspergillosis by reduced-intensity conditioning cord blood transplantation.2010

    • Author(s)
      Hatakeyama N, Hori T, et al.
    • Journal Title

      Peditr Transplant

      Volume: 14 Pages: 4-10

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed

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Published: 2009-04-01   Modified: 2016-04-21  

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