Genetic variability of human cytomegalovirus UL97 gene which associated with resistance to ganciclovir
| Project/Area Number |
21591392
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOTO Yuko 札幌医科大学, 医学部, 講師 (10404659)
HORI Tsukasa 札幌医科大学, 医学部, 助教 (20398324)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | ヒトサイトメガロウイルス / UL97遺伝子 / ガンシクロビル / CMV / 分子疫学 / UL97 / 免疫不全 / サイトメガロウイルス |
|---|
| Research Abstract |
UL97 codons 439 to 645 from 61 CMV isolates from 61 immunocompetent Japanese infants and children were sequenced directly. No known GCV resistance mutations were found, meaning that the UL97 mutation had resulted from the use of GCV. On the other hand, a mutation at codon 605(D to E) was frequently identified(56/61 : 91. 8%). This could be a genetic marker for HCMV in East Asian counties, because of its low prevalence in the strains of HCMV circulating in Western countries.
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Report
(4 results)
Research Products
(9 results)
