Elucidation of new mechanisms of RSV infection by clinical isolate analysis using a mouse model
| Project/Area Number |
21591394
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Yuko 福島県立医科大学, 医学部, 准教授 (60305357)
HOSOYA Mistuaki 福島県立医科大学, 医学部, 教授 (80192318)
SUZUTANI Tastuo 福島県立医科大学, 医学部, 教授 (40196895)
KAWASAKI Yukihiko 福島県立医科大学, 医学部, 准教授 (00305369)
NISHIMURA Hidekazu 仙台医療センター, 臨床研究部, 室長 (50172698)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 小児感染症学 / RSV / 臨床分離株 / マウスモデル / 遺伝子解析 / 統計樹解析 / Th1 / Th2 / マウス / 動物実験 / 気道粘液 / 気道抵抗 |
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| Research Abstract |
There has not been conclusion about Th2 induction after RSV infection both in clinical researches and basic researches. Five gene mutations with amino acids alteration are reported in F gene by comparison among Th2 derivation RSV strain(RSV-Line 19), RSV-A2 strain and RSV-Long strain. We analyzed an F gene about 49 RSV clinical isolates and analyzed a gene mutation reported previously. Gene mutation of previous report was found in five isolates, but mutation was 1 or two places.
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Report
(4 results)
Research Products
(23 results)
