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Elucidation of new mechanisms of RSV infection by clinical isolate analysis using a mouse model

Research Project

Project/Area Number 21591394
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionFukushima Medical University

Principal Investigator

HASHIMOTO Koichi  福島県立医科大学, 医学部, 准教授 (50322342)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Yuko  福島県立医科大学, 医学部, 准教授 (60305357)
HOSOYA Mistuaki  福島県立医科大学, 医学部, 教授 (80192318)
SUZUTANI Tastuo  福島県立医科大学, 医学部, 教授 (40196895)
KAWASAKI Yukihiko  福島県立医科大学, 医学部, 准教授 (00305369)
NISHIMURA Hidekazu  仙台医療センター, 臨床研究部, 室長 (50172698)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords小児感染症学 / RSV / 臨床分離株 / マウスモデル / 遺伝子解析 / 統計樹解析 / Th1 / Th2 / マウス / 動物実験 / 気道粘液 / 気道抵抗
Research Abstract

There has not been conclusion about Th2 induction after RSV infection both in clinical researches and basic researches. Five gene mutations with amino acids alteration are reported in F gene by comparison among Th2 derivation RSV strain(RSV-Line 19), RSV-A2 strain and RSV-Long strain. We analyzed an F gene about 49 RSV clinical isolates and analyzed a gene mutation reported previously. Gene mutation of previous report was found in five isolates, but mutation was 1 or two places.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (23 results)

All 2012 2011 2010 2009

All Journal Article (11 results) (of which Peer Reviewed: 10 results) Presentation (5 results) Book (7 results)

  • [Journal Article] Survey of Subacute Sclerosing Panencephalitis in Japan2012

    • Author(s)
      Abe Y, Hashimoto K, et al
    • Journal Title

      J Child Neurol

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uteroglobulin-related protein 1 and severity of respiratory syncytial virus infection in children admitted to hospital.2011

    • Author(s)
      Hashimoto K、Katayose M、Sakuma H、Kawasaki Y、Sumikoshi M、Sakata H、Sato M、Ohara S、Abe Y、Watanabe、Sato T、Ishibashi K、Suzutani T、Munakata M、Hosoya M
    • Journal Title

      J Med Virol

      Volume: 83巻 Pages: 1086-92

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Uteroglobulin-related protein 1 and severity of respiratory syncytial virus infection in children admitted to hospital2011

    • Author(s)
      Hashimoto K, et al
    • Journal Title

      J Med Virol

      Volume: 83 Issue: 6 Pages: 1086-92

    • DOI

      10.1002/jmv.22073

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of SOCS3 increases susceptibility of renal cell carcinoma to interferon-α2011

    • Author(s)
      Tomita S, Hashimoto K, et al
    • Journal Title

      Cancer Sci

      Volume: 102 Issue: 1 Pages: 57-63

    • DOI

      10.1111/j.1349-7006.2010.01751.x

    • NAID

      10029288385

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum SP-D levels as a biomarker of lung injury in respiratory syncytial virus bronchiolitis.2011

    • Author(s)
      Kawasaki Y, Hashimoto K, et al.
    • Journal Title

      Pediatr Pulmonol.

      Volume: 46 Pages: 18-22

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glucocorticoid receptor expression and cortisol level in cord blood of term infants.2011

    • Author(s)
      Imamura T, Hashimoto K, et al.
    • Journal Title

      J Matern Fetal Neonatal Med.

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RSウイルス感染と喘息発症. RSV感染とSOCS発現について2010

    • Author(s)
      橋本浩一、川崎幸彦、細矢光亮
    • Journal Title

      日本小児アレルギー学会誌

      Volume: 24巻 Pages: 61-70

    • NAID

      10029555670

    • Related Report
      2011 Final Research Report
  • [Journal Article] The trend of drug-resistant Streptococcus pneumoniae from nasopharynx of children.2010

    • Author(s)
      Matsumoto A, Hashimoto K, et al.
    • Journal Title

      J Infect Chemother.

      Volume: 16 Pages: 255-259

    • NAID

      10027190310

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] プロスタサイクリンのRSV感染症病態への関与2009

    • Author(s)
      橋本浩一、川崎幸彦、片寄雅彦、佐久間弘子、錫谷達夫、細矢光亮
    • Journal Title

      福島医学雑誌

      Volume: 59巻 Pages: 161-171

    • NAID

      10031185700

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] DSCG reduces RSV-induced illness in RSV-infected mice2009

    • Author(s)
      Hashimoto K、Mori S、Hashimoto Y、Kaneko H、Ishibashi K、Ishioka K、Kawasaki Y、Peebles RS Jr、Munakata M、Hosoya M、Suzutani T
    • Journal Title

      J Med Virol

      Volume: 81巻 Pages: 354-61

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] RSV replication is attenuated by counteracting expression of the suppressor of cytokine signaling(SOCS) molecules2009

    • Author(s)
      Hashimoto K、Ishibashi K、Ishioka K、Zhao D、Sato M、Ohara S、Abe Y、Kawasaki Y、Sato Y、Yokota S、Fujii N、Peebles RS Jr、Hosoya M、Suzutani T
    • Journal Title

      Virology

      Volume: 391巻 Pages: 162-70

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 臨床分離株解析によるRSV病原性発現の新たな機序の解明2011

    • Author(s)
      橋本浩一
    • Organizer
      第43回日本小児感染症学会総会・学術集会
    • Place of Presentation
      岡山県岡山市
    • Year and Date
      2011-10-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] RSV感染重症化とUGRP 1プロモーター領域の遺伝子多型および発現に関する検討2011

    • Author(s)
      橋本浩一
    • Organizer
      第52回日本臨床ウイルス学会学
    • Place of Presentation
      三重県津市
    • Year and Date
      2011-06-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 臨床分離株解析によるRSV病原性発現の新たな機序の解明2011

    • Author(s)
      橋本浩一
    • Organizer
      第43回日本小児感染症学会
    • Place of Presentation
      岡山市
    • Related Report
      2011 Final Research Report
  • [Presentation] There is no association between the -112G/A polymolphism of UGRP1 and serum UGRP1, and severity of RSV infection in Hospitaiized children.2010

    • Author(s)
      Koichi Hashimoto
    • Organizer
      第7回RSウイルス国際シンポジウム2010
    • Place of Presentation
      ロッテルダム
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Uteroglobulin-Related Protein 1 and severity of RSV infection in Hospitalized children2010

    • Author(s)
      橋本浩一
    • Organizer
      第7回RSV国際シンポジウム
    • Place of Presentation
      アムステルダム
    • Related Report
      2011 Final Research Report
  • [Book] Fetal & Neonatal Medicine、RSウイルス-感染のメカニズムと反復性喘鳴の発症-2011

    • Author(s)
      細矢光亮、橋本浩一
    • Publisher
      メディカルレビュー社
    • Related Report
      2011 Final Research Report
  • [Book] 小児科臨床ピクシス2011

    • Author(s)
      橋本浩一
    • Publisher
      中山書店
    • Related Report
      2011 Final Research Report
  • [Book] 小児科学レクチャーよくみる子どもの感染症Q & A、RSウイルス・ヒトメタニューモウイルス2011

    • Author(s)
      橋本浩一、細矢光亮
    • Publisher
      総合医学社
    • Related Report
      2011 Final Research Report
  • [Book] RSウイルス-感染のメカニズムと反復性喘鳴の発症Fetal & Neonatal Medicine2011

    • Author(s)
      細矢光亮, 橋本浩一
    • Total Pages
      2
    • Publisher
      メディカルレビュー社
    • Related Report
      2011 Annual Research Report
  • [Book] RSウイルス感染小児科臨床ピクシス2011

    • Author(s)
      橋本浩一
    • Total Pages
      6
    • Publisher
      中山書店
    • Related Report
      2011 Annual Research Report
  • [Book] 小児科学レクチャーRSウイルス・ヒトメタニューモウイルスよくみる子どもの感染症Q&A2011

    • Author(s)
      橋本浩一、細矢光亮
    • Total Pages
      7
    • Publisher
      総合医学社
    • Related Report
      2011 Annual Research Report
  • [Book] 小児科臨床ピクシス 小児感染症2011

    • Author(s)
      橋本浩一
    • Publisher
      中山書店
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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