Effects of carnitine to oxygen stress occurred in the reperfused myocardiumfrom the cyanotic congenital heart disease model

Research Project

Project/Area Number	21591395
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Pediatrics
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	ITOI Toshiyuki 京都府立医科大学, 医学研究科, 准教授 (10264780)
Co-Investigator(Kenkyū-buntansha)	TOIYAMA Kentarou 京都府立医科大学, 医学研究科, 助教 (00433285)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	未熟心 / 循環器 / 心筋代謝 / 再灌流障害 / 脂質
Research Abstract	We have created a rat model of cyanotic congenital heart disease by chronic hypoxic exposure. A constant Langendorff coronary perfusion system was adopted as a new model for examination of cardiac ischemic reperfusion injury. The result was that, contrary to expectations, the hearts from low oxygen exposed rats showed less suppression of cardiac function after ischemic reperfusion to the contrast with the control hearts. Currently, we are considering the sequential changes in the composition of membrane lipids, changes in lipid peroxide production, and changes in the concentration of antioxidant enzymes.