Development and the etiology investigation of the effective cure of the Kawasaki disease : Molecular genetic base and proteome analysis

• Project/Area Number: 21591397
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kitasato University
• Principal Investigator: ISHII Masahiro 北里大学, 医学部, 教授 (90222950)
• Co-Investigator(Kenkyū-buntansha): NAKAHATA Yayoi 北里大学, 医学部, 講師 (20306591) ; KIMURA Sumito 北里大学, 医学部, 助教 (40365151)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 小児循環器学 / 川崎病 / 免疫グロブリン / ステロイドパルス療法 / 江上スコア / ステロイドパルス / 分子生物学 / 冠動脈 / ブドウ球菌 / RNA / 小児循環器病学 / 川査病 / 冠動脈瘤 / 初期治療 / スコアリングシステム / 炎症

Research Abstract

It was proved that combination of immunoglobulin therapy and steroid pulse therapy was clinically effective as primary care for the intractable Kawasaki disease by a randomness prospective competitive examination. I inspected the mechanism of this effective cure by molecular genetic technique at the same time. In addition, the effectiveness of the stratification score of the intractable Kawasaki disease was inspected in a molecular genetic study. I developed the cure for the example which start of therapy was late for. It is suggested that some kind of viral infection affects it about the etiology and is studying it continuously.

Research Products

• [Journal Article] Late intravenous immunoglobulin treatment in patients with Kawasaki (2012)
  • Author(s): Muta H, IshiiM, Yashiro M, Uehara R, Nakamura Y
  • Journal Title: Kawasaki disease Pediatr Volume: 129
• [Journal Article] Corticosteroido pulse conbination therapy for refractory Kawasaki disease a randomized trial (2012)
  • Author(s): Ogata S, Ogihara Y, Honda T, Kon S, Akiyama K, Ishii M
  • Journal Title: Pediatr Volume: 129
• [Journal Article] Percutaneous bilateral pulmonary artery banding using re-expandable covered stent ; Preliminary animal study (2011)
  • Author(s): Nakahata Y, Tomita H, Kimura S, Ando H, Honda T, Takanashi Ishii M
  • Journal Title: Kitasato Medical Journal Volume: 41 Pages: 165-169
  • NAID: 40019009583
• [Journal Article] Incomplete Kawasaki disease : early findings consist of congestive heart failure due to valvular heart disease (2011)
  • Author(s): Honda T, Ogata S, Ishii M
  • Journal Title: Heart Asia Volume: 3 Pages: 92-92
• [Journal Article] Noninvasive assessment of pulmonary vascular resistance and pressure in patients with congenital heart disease : a new method using M-mode echocardiography (2011)
  • Author(s): Kimura S, Nakahata Y, Honda T, Ando H, Ogata S, Akiyama K, Ogihara Y, Ishii M
  • Journal Title: J Echocardiogr Volume: 9 Pages: 137-141
  • NAID: 10030334360
• [Journal Article] Percutaneous bilateral pulmonary artery banding using re-expandable covered stent ; Preliminary animal study. Kitasato Medical Journal (2011)
  • Author(s): 中畑弥生, 石井正浩
  • Journal Title: Kitasato Medical Journal Volume: 41 Pages: 165-169
  • Peer Reviewed
• [Journal Article] Noninvasive assessment of pulmonary vascular resistance and pressure in patients with congenital heart disease : a new method using M-mode echocardiography (2011)
  • Author(s): 木村純人, 石井正浩
  • Journal Title: Journal of ecocardiography Volume: 9 Pages: 137-141
  • NAID: 10030334360
  • Peer Reviewed
• [Journal Article] Incomplete Kawasaki disease : early findings consist of congestive heart failure due to valvular heart disease (2011)
  • Author(s): 本田崇, 石井正浩
  • Journal Title: Heart Asia Volume: 3 Pages: 92-92
  • Peer Reviewed
• [Journal Article] Corticosteroido pulse conbination therapy for refractory Kawasaki disease : a randomized trial (2011)
  • Author(s): 緒方昌平, 石井正浩
  • Journal Title: Pediatrics Volume: 129 Pages: 17-23
  • Peer Reviewed
• [Journal Article] Nakamura Y.Late intravenous immunoglobulin treatment in patients with Kawasaki disease (2011)
  • Author(s): 牟田広実, 石井正浩
  • Journal Title: Pediatrics Volume: 129 Pages: 291-297
  • Peer Reviewed
• [Journal Article] Health-Related Quality of life in Adolescents and Youug Adults with a History of Kawasaki Disease. (2010)
  • Author(s): 牟田広実, 石井正浩
  • Journal Title: The Journal of Pediatrics Volume: 156 Pages: 439-443
  • Peer Reviewed
• [Journal Article] Percutaneous Coronary Intervention versus Coronary Artery Bypass Grafting for Stenotic Lesions after Kawasaki Disease. (2010)
  • Author(s): 牟田広実, 石井正浩
  • Journal Title: The Journal of Pediatrics Volume: 157 Pages: 120-126
  • Peer Reviewed
• [Journal Article] Kikuchi- Fujimoto disease developed into autoimmune disease : a report of two cases. (2010)
  • Author(s): 緒方昌平, 石井正浩
  • Journal Title: Mod Rheumatol Volume: 20 Pages: 301-305
  • NAID: 10027169496
  • Peer Reviewed
• [Journal Article] Clinical Score and Transcript Abundance Patterns Identify Kawasaki Disease Patients Who May Benefit From Addition of Methylprednisolone (2009)
  • Author(s): 緒方昌平
  • Journal Title: Pediatric Research Vol.66 Pages: 577-584
  • Peer Reviewed
• [Journal Article] 中枢神経症状を合併した川崎病の2例:髄液中サイトカイン動態の検討 (2009)
  • Author(s): 緒方昌平
  • Journal Title: 日本小児救急医学会雑誌 8巻 Pages: 327-333
  • Peer Reviewed
• [Journal Article] 成人期川崎病による冠動脈病変へのカテーテルインターベンションの適応と成績をみる (2009)
  • Author(s): 石井正浩
  • Journal Title: Vascular Medicine Vol.6 Pages: 35-41
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 石井正浩
  • Journal Title: 内科学症例図説(朝倉書店) Pages: 63-64
• [Presentation] Clinical utility of a new strategy for preventing coronary artery lesions in refractory Kawasaki disease patients : a randomized prospective study (2012)
  • Author(s): 石井正浩
  • Organizer: The 10th International Kawasaki Disease Symposium
  • Place of Presentation: 京都
  • Year and Date: 2012-02-09
• [Presentation] Perctaneous coronary intervension for Kawasaki disease (2012)
  • Author(s): 石井正浩
  • Organizer: The 10th International Kawasaki Disease Symposium
  • Place of Presentation: 京都
  • Year and Date: 2012-02-09
• [Presentation] Nonoyama M, Minoura K, Ishii M.The immune dynamics of Kawasaki disease and vaccination (2012)
  • Author(s): 佐藤加代子, 石井正浩
  • Organizer: The 10th International Kawasaki Disease Symposium
  • Place of Presentation: 京都
  • Year and Date: 2012-02-08
• [Presentation] Use of z-score to compare coronary artery outcomes between the US and Japan (2012)
  • Author(s): 緒方昌平, 石井正浩
  • Organizer: The 10th International Kawasaki Disease Symposium
  • Place of Presentation: 京都
  • Year and Date: 2012-02-08
• [Presentation] Clinical utility of a new strategy for preventing coronary artery lesions in refractory Kawasaki disease patients : a randomized prospective study (2012)
  • Author(s): Ishii M, Ogata S, Ogihara Y, Sato K, Ebato T
  • Organizer: The 10th International Kawasaki Disease Symposium
  • Place of Presentation: Kyoto
• [Presentation] The immune dynamics of Kawasaki disease and vaccination (2012)
  • Author(s): Sato K, Inagaki H, Kon S, Ogihara Y, Soeda Y, Iwanami N, Nonoyama M, Minoura K, Ishii M
  • Organizer: The 10th International Kawasaki Disease Symposium
  • Place of Presentation: Kyoto
• [Presentation] Use of z-score to compare coronary artery outcomes between the US and Japan (2012)
  • Author(s): Ogata S, Ueda K, Tremouler A, Ogihara Y, Ishii M, Burns JC
  • Organizer: The 10th International Kawasaki Disease Symposium
  • Place of Presentation: Kyoto
• [Presentation] Perctaneous coronary intervension for Kawasaki disease. Keynote Lecture III (2012)
  • Author(s): Ishii M
  • Organizer: The 10th International Kawasaki Disease Symposium
  • Place of Presentation: Kyoto
• [Presentation] Cardiovascular problems and management of Kawasaki disease (2011)
  • Author(s): Ishii M
  • Organizer: USCD Grandround 2011
  • Place of Presentation: San Diego
  • Year and Date: 2011-11-12
• [Presentation] Cardiovascular problems and management of Kawasaki disease (2011)
  • Author(s): 石井正浩
  • Organizer: USCD Grandround
  • Place of Presentation: サンディエゴ
  • Year and Date: 2011-11-12
• [Presentation] 難治性川崎病に対する初期治療としての免疫グロブリンとステロイドパルスの併用療法が冠動脈病変に与える影響:前視法的検討 (2011)
  • Author(s): 石井正浩, 緒方昌平, 扇原義人, 本田崇
  • Organizer: 第31回日本川崎病学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2011-10-01
• [Presentation] 川崎病患者における11～20病日に開始された免疫グロブリンの治療効果 (2011)
  • Author(s): 牟田広実, 石井正浩
  • Organizer: 第31回日本川崎病学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2011-10-01
• [Presentation] 川崎病成人期の問題点と治療 (2011)
  • Author(s): 石井正浩
  • Organizer: 第59回日本心臓病学会
  • Place of Presentation: 神戸
  • Year and Date: 2011-09-24
• [Presentation] 川崎病患者における11～20病日に開始された免疫グロブリンの治療効果 (2011)
  • Author(s): 牟田広実, 石井正浩, 屋代真弓, 上原里程, 中村好一
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-08-14
• [Presentation] The efficacy and safety of new strategy for refractory Kawasaki disease (2011)
  • Author(s): Ishii M, OgataS, Honda T, Ogihara Y
  • Organizer: Annual meeting of the association for European Pediatric cardiology
  • Place of Presentation: Spain/Granada
  • Year and Date: 2011-05-20
• [Presentation] The efficacy and safety of new strategy for refractory Kawasaki disease (2011)
  • Author(s): 石井正浩
  • Organizer: Annual meeting of the association for European Pediatric cardiology
  • Place of Presentation: スペイン
  • Year and Date: 2011-05-20
• [Presentation] 川崎病成人期の問題点と治療パネルディスカッション小児心疾患の再診治療 (2011)
  • Author(s): 石井正浩
  • Organizer: 第59回日本心臓病学会
  • Place of Presentation: 神戸
• [Presentation] The Efficacy And Safety Of New Strategy Kasawaki Disease : A Clinical Trial In Single Institution. (2010)
  • Author(s): 石井正浩
  • Organizer: American Heart Association2010
  • Place of Presentation: シカゴ(アメリカ合衆国)
  • Year and Date: 2010-11-15
• [Presentation] 難治性川崎病に対する治療戦略:メチルプレドニンパルス併用療法の有用性 (2010)
  • Author(s): 緒方昌平, 石井正浩
  • Organizer: 第30回日本川崎病学会学術集会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-10-10
• [Presentation] 洞不全症候群をきたしたFontan手術後の川崎病の一例 (2010)
  • Author(s): 本田崇, 石井正浩
  • Organizer: 第30回日本川崎病学会学術集会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-10-10
• [Presentation] 胸水貯留を合併した川崎病5例:血中VEGFによる検討 (2010)
  • Author(s): 扇原義人, 石井正浩
  • Organizer: 第30回日本川崎病学会学術集会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-10-10
• [Presentation] 単心房単心室に対して心外導管を用いたFontan術を施行し、術後遠隔期に感染による導管閉鎖をきたした一例 (2010)
  • Author(s): 大岡麻理, 石井正浩
  • Organizer: 第6回神奈川小児循環器研究会
  • Place of Presentation: ホテルキャメロットジャパン(神奈川)
  • Year and Date: 2010-09-25
• [Presentation] Percutaneous Coronary Intervention for Kawasaki Disease (2010)
  • Author(s): 石井正浩
  • Organizer: 第46回日本小児循環器学会総会学術集会
  • Place of Presentation: シェラトングランデ東京ベイホテル(千葉)
  • Year and Date: 2010-07-07
• [Presentation] Stress test and quality of life in long-term after kawasaki (2010)
  • Author(s): 石井正浩
  • Organizer: Association for European pediatric cardiology2010
  • Place of Presentation: インスブルッグ(オーストリア)
  • Year and Date: 2010-05-28
• [Presentation] 一絨毛膜二羊膜性双胎の心機能評価:心エコーと血清学的検査を用いた検討 (2010)
  • Author(s): 木村純人, 石井正浩
  • Organizer: 第21回日本心エコー図学会学術集会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2010-05-14
• [Presentation] 難治性川崎病に対するステロイドパルス併用療法:マイクロアレイ解析による検討 (2010)
  • Author(s): 緒方昌平, 石井正浩
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 盛岡市民文化ホール(岩手)
  • Year and Date: 2010-04-24
• [Presentation] Catheter Intervention for Kawasaki Disease (2009)
  • Author(s): 石井正浩
  • Organizer: 17th Asian Pacific Congress of Cardiology
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2009-05-23
• [Book] 循環器病学 基礎と臨床 (2010)
  • Author(s): 石井正浩
  • Publisher: 西村書店