Development and the etiology investigation of the effective cure of the Kawasaki disease : Molecular genetic base and proteome analysis
| Project/Area Number |
21591397
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAHATA Yayoi 北里大学, 医学部, 講師 (20306591)
KIMURA Sumito 北里大学, 医学部, 助教 (40365151)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 小児循環器学 / 川崎病 / 免疫グロブリン / ステロイドパルス療法 / 江上スコア / ステロイドパルス / 分子生物学 / 冠動脈 / ブドウ球菌 / RNA / 小児循環器病学 / 川査病 / 冠動脈瘤 / 初期治療 / スコアリングシステム / 炎症 |
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| Research Abstract |
It was proved that combination of immunoglobulin therapy and steroid pulse therapy was clinically effective as primary care for the intractable Kawasaki disease by a randomness prospective competitive examination. I inspected the mechanism of this effective cure by molecular genetic technique at the same time. In addition, the effectiveness of the stratification score of the intractable Kawasaki disease was inspected in a molecular genetic study. I developed the cure for the example which start of therapy was late for. It is suggested that some kind of viral infection affects it about the etiology and is studying it continuously.
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Report
(4 results)
Research Products
(45 results)
