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A haploinsufficient gene and the modification factors : Spectrum changing of cardiovascular anomalies in the Foxc2 mutant mouse by genetic backgrounds and maternal factors

Research Project

Project/Area Number 21591400
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionTokyo Women's Medical University

Principal Investigator

MORISHIMA Masae  東京女子医科大学, 医学部, 助教 (00241068)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords循環器発生 / 遺伝子疾患 / ハプロ不全遺伝子 / microdeletion症候群 / ハプロ不全
Research Abstract

Foxc2 is one of the haploinsufficient gene of which mutant causes cardiovascular anomalies. This project was done to analyze the cardiovascular anomalies in the Foxc2 mutant mouse from different background strains and the modification factors. The phenotype of the cardiovascular anomaly was variational depending on the genetic background. Analysis of the mutant embryos indicated that not only the cascade genes of Foxc2 but also the others, such as maternal hyperlipidemia, could affect to make the genetic anomaly severer.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (17 results)

All 2012 2011 2010 2009 Other

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (11 results) Remarks (1 results)

  • [Journal Article] Foxc2欠失マウス胎仔におけるリンパ管の形態形成2012

    • Author(s)
      森島正恵、清水一彦、久米努、江崎太一
    • Journal Title

      リンパ学Japanese Journal of Lymphology

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Repply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivateves in mice2011

    • Author(s)
      Takashi Okubo, Akinori Kawamura, Jun Takahashi, Hisato Yagi, Masae Morishima, Rumiko Matsuoka, Shinji Takada
    • Journal Title

      Devlopment

      Volume: 138 Pages: 229-348

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analysis of Down syndrome-associated heart defects in mice2011

    • Author(s)
      Liu C, Morishima M, et al
    • Journal Title

      Human Genetics

      Volume: 130 Issue: 5 Pages: 623-632

    • DOI

      10.1007/s00439-011-0980-2

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice2011

    • Author(s)
      Tadashi Okubo
    • Journal Title

      Development

      Volume: Vol.138 Pages: 339-348

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Foxc2欠失マウス胎仔におけるリンパ管の形態形成

    • Author(s)
      森島正恵, 清水一彦, 久米努, 江崎太一
    • Journal Title

      リンパ学

      Volume: 35巻(掲載確定)

    • Related Report
      2011 Final Research Report
  • [Presentation] Pharyngeal Arch Anomalies in Foxc2 Null Mouse Embryos2011

    • Author(s)
      Masae Morishima, Kazuhiko Shimizu, Shun-ichi Morikawa, Tsutomu Kume, Toshio Nakanishi, Taichi Ezki
    • Organizer
      Weinstein Cardiovascular Development Conference
    • Place of Presentation
      Chincinnati, OH, USA
    • Year and Date
      2011-05-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Foxc2欠失マウス胎仔におけるリンパ管の形態形成2011

    • Author(s)
      森島正恵, 清水一彦, 久米努, 江崎太一
    • Organizer
      第35回日本リンパ学会総会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-05-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Foxc2欠失マウス胎仔におけるリンパ管の形態形成2011

    • Author(s)
      禁島正恵、清水一彦、久米努、江崎太一
    • Organizer
      第35回日本リンパ学会総会シンポジウム
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-05-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Foxc2欠失マウスにおける鰓弓異常の形態学的特徴2011

    • Author(s)
      森島正恵, 江崎太一
    • Organizer
      第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Morphological Characterization of the Pharyngeal Arch Anomalies in the Foxc2 Null Mouse2011

    • Author(s)
      森島正恵
    • Organizer
      第116回日本解剖学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genetics of Down syndrome : Focus on cardiovascular malformations2011

    • Author(s)
      Liu C, Morishima M, et al
    • Organizer
      Weinstein Cardiovascular Development Conference
    • Place of Presentation
      Cincinnati, OH, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Pharyngeal Arch Anomalies in Foxc2 Null Mouse Embryos2011

    • Author(s)
      Morishima M, et al
    • Organizer
      Weinstein Cardiovascular Development Conference
    • Place of Presentation
      Cincinnati, OH, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] The genetic background and maternal intake of fat diet affect the risk of having offspring with congenital heart disease2010

    • Author(s)
      Masae Morishima, Hisato Yagi, Tsutomu Kume, Rumko Matsuoka
    • Organizer
      International Research and educational Institute for Integrated Medical Sciences Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2010-02-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Foxc2欠損マウスにおける心血管奇形の系統差2009

    • Author(s)
      森島正恵, 八木寿人, 久米努, 松岡留美子
    • Organizer
      第8回心臓血管発生研究会
    • Place of Presentation
      郡山
    • Year and Date
      2009-07-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Foxc2欠損マウスにおける心血管奇形と系統差。2009

    • Author(s)
      森島正恵
    • Organizer
      第8回心臓血管研究会
    • Place of Presentation
      磐梯熱海(福島県)
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Spectrum of the Cardiovascular Anomalies and the Background Strain in the Foxc2 Deficient Mouse2009

    • Author(s)
      Masae Morishima, Hisato Yagi, Tsutomu Kume, Rumiko Matsuoka
    • Organizer
      Weinstein Cardiovascular Development Conference
    • Place of Presentation
      Sanfrancisco, USA
    • Year and Date
      2009-05-08
    • Related Report
      2011 Final Research Report
  • [Remarks] 「Morishima M et al. Spectrum of the CardiovascularAnomalies and the Background Strain in the Foxc2 Deficient Mouse. Weinstein Cardiovascular Development Conference, San Francisco, USA, May 7-9 2009」はインフルエンザによる渡航禁止令のため、抄録上での発表。

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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