A haploinsufficient gene and the modification factors : Spectrum changing of cardiovascular anomalies in the Foxc2 mutant mouse by genetic backgrounds and maternal factors
Project/Area Number |
21591400
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pediatrics
|
Research Institution | Tokyo Women's Medical University |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 循環器発生 / 遺伝子疾患 / ハプロ不全遺伝子 / microdeletion症候群 / ハプロ不全 |
Research Abstract |
Foxc2 is one of the haploinsufficient gene of which mutant causes cardiovascular anomalies. This project was done to analyze the cardiovascular anomalies in the Foxc2 mutant mouse from different background strains and the modification factors. The phenotype of the cardiovascular anomaly was variational depending on the genetic background. Analysis of the mutant embryos indicated that not only the cascade genes of Foxc2 but also the others, such as maternal hyperlipidemia, could affect to make the genetic anomaly severer.
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Report
(4 results)
Research Products
(17 results)