Vasculitis after Kawasaki disease is a possibility of risk factors for cerebrovascular disease?
| Project/Area Number |
21591401
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUDA Kenji 久留米大学, 医学部, 准教授 (10399173)
KUDO Yoshiyuki 久留米大学, 医学部, 助教 (10368920)
TGUCHI Chikako 久留米大学, 医学部, 助教 (40352166)
手島 靖夫 久留米大学, 医学部, 助教 (50352167)
西野 裕 久留米大学, 医学部, 助教 (60412524)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 川崎病 / 血管内皮機能 / 脳血管機能 |
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| Research Abstract |
<Purpose> To clarify the Vasculitis after Kawasaki disease(KD) is a possibility of risk factors for cerebrovascular disease。<patients and methods> we selected 27 KD patients with coronary artery lesion(CAL)(Group A), 12 KD patients with completely regressed Coronary lesions(Group B), 10 KD patients who had normal coronary arteries during the acute phase(Group C), and 17 healthy controls(CONT). Using high-resolution ultrasound system, distal intima-media thickness(IMT), systolic and diastolic internal diameter of right carotid artery, blood pressure were measured. Carotid arterial stiffness and distensibility were calculated using known formula. Using laser-Doppler monitoring system(PeriFlux system 5000), peripheral vascular function(The resting laser Doppler perfusion unit(rest PU) was monitored and then the forearm cuff was inflated to 200 mm Hg. After 3 minutes occlusion was suddenly released and maximum laser Doppler perfusion unit(max PU) and time to maximum perfusion(Time to max PU) were recorded till hyperemia subsided.) were measured.<results> Stiffness of A was significantly higher than the other three groups and distensibility of A was significant lower than the other three groups. There were no significant differences in IMT, rest PU and max PU. However, Time to max PU in group A was significantly longer than in the other 3 groups.<Conclusion> These data indicates that carotid arterial wall in patients with CAL is as thick as normal but stiffer and distensible, and peripheral micro-vascular function, including endothelium, was normal in patients with regressed coronary arteries and normal coronary arteries, and impaired in patients with CAL. These may point towards possibility of preclinical atherosclerosis and cerebrovascular disease in patients with KD wit CAL. Furtherinvestigation must be need to resolve clinical and pathological prognosis after KD.
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Report
(4 results)
Research Products
(93 results)
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[Journal Article] Long-term prognosis of patients with Kawasaki disease complicated by giant coronary aneurysms : a single-institution experience2011
Author(s)
Suda K, Iemura M, Nishiono H, Teramachi Y, Koteda Y, Kishimoto S, Kudo Y, Itoh S, Ishii H, Ueno T, Tashiro T, Nobuyoshi M, Kato H, Matsuishi T.
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Journal Title
Circulation
Volume: 123
Issue: 17
Pages: 1836-42
DOI
Related Report
Peer Reviewed
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[Presentation] Native CoAにステント留置した3例2012
Author(s)
吉本裕良, 高瀬隆太, 工藤嘉公, 家村素史, 前野泰樹, 須田憲治, 松石豊次郎, 上野高史
Organizer
第23回Japan Pediatric Interventional Cardiology学会
Place of Presentation
秋田
Year and Date
2012-01-19
Related Report
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[Presentation] 川崎病右腋窩動脈瘤内血栓に対してPulse Infusion Thrombolysis (PIT)を施行した一例2012
Author(s)
家村素史, 古本裕良, 高瀬隆太, 寺町陽三, 籠手田雄介, 伊藤晋一, 工藤嘉公, 前野泰樹, 須田憲治, 上野高史, 松石豊次郎
Organizer
第23回Japan Pediatric Interventional Cardiology学会
Place of Presentation
秋田
Year and Date
2012-01-19
Related Report
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[Presentation] 川崎病右腋窩動脈瘤内血栓に対してPulse Infusion Thrombolysis(PIT)を施行した一例2012
Author(s)
家村素史, 吉本裕良, 高瀬隆太, 寺町陽三, 籠手田雄介, 伊藤晋一, 工藤嘉公, 前野泰樹, 須田憲治, 上野高史, 松石豊次郎
Organizer
第23回Japan Pediatric Interventional Cardiology学会
Place of Presentation
秋田
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[Presentation] Acute coronary syndrome in adults with a history of Kawasaki disease : A Japanese nationwide survey2011
Author(s)
Mitani Y, Tsuda E, Kato H, Ogawa S, Nakamura Y, Takahashi K, Ayusawa M, Kobayashi T, Ichida F, Matsushima M, Kamata M, Higaki T, Suda K, Ohashi H, Yokoi H, Hamaoka K.
Organizer
American Heart Association 2011
Place of Presentation
Orland, USA
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