| Project/Area Number |
21591406
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
SHIRAISHI Isao 独立行政法人国立循環器病研究センター, 小児循環器部, 部長 (80295659)
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| Co-Investigator(Renkei-kenkyūsha) |
森島 正恵 東京女子医科大学, 発生解剖学教室, 特任助教 (00241068)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 先天性心疾患 / 心臓形態形成 / レチノイン酸 / 催奇形 / 遺伝子異常 / 二次心臓領域 / 大血管転位 / ファロー四徴 / ファロー四徴症 / 遺伝子 / 心臟形態形成 |
|---|
| Research Abstract |
Maternal administration of retinoic acid(E6.5-E9.5) induce wide spectrum of congenital heart anomalies including heterotaxy syndrome, situs inversus totalis, univentricular heart, common atrioventricular connection, hypoplastic left heart, persistent truncus arteriosus, aorto-pulmonary window, complete transposition of the great arteries, tetralogy of Fallot, interrupted aortic arch, which are similar to human congenital heart disease. We analyzed gene expression of the secondary heart field and the cardiac outflow tract of this mouse model by using DNA microarray. We found various sort of genes up-regulated and down-regulated at these areas.
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