| Project/Area Number |
21591407
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OHTA Hidenobu 東北大学, 病院, 非常勤講師 (80422103)
MIURA Tuichiro 東北大学, 病院, 特任助手 (20419229)
KITANISHI Ryuta 東北大学, 病院, 非常勤講師 (20436116)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 子宮内炎症 / 脳血流量 / 脳虚血 / 胎児 / brain-sparing effect / 脳室周囲白質軟化 / 脳白質損傷 / ヒツジ / brain sparing effect / 脳血質損傷 / periventricular leukomalacia |
|---|
| Research Abstract |
To determine the effect of cerebral ischemia and/or intrauterine inflammation on the development of oligodendroglial lineage in cerebral white matter, chronically instrumented fetal sheep was induced hemorrhagic hypotensionand/ornecrotizing funifitis. The brain was performed immunohistochemistry of NG2, O4, CNPase and PLP and then integrated density of each stain was statistically compared. The results suggested that in the premature fetal sheep, cerebral ischemia and/or intrauterine inflammation accelerated the oligodendroglial maturity from precursor to post-mitotic cells rather than induced apoptosis to precursor cells in the cerebral white matter.
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