Baby-friendly perinatal care with non-invasive monitoring of neonatal stress

• Project/Area Number: 21591413
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kanazawa University
• Principal Investigator: NAGAOKI Syuya 金沢大学, 附属病院, 講師 (70361996)
• Co-Investigator(Kenkyū-buntansha): YACHIE Akihiro 金沢大学, 医学系, 教授 (40210281)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 新生児 / バイオピリン / 酸化ストレス / モニタリング / 非侵襲的 / heme oxygenase

Research Abstract

In this study, we aimed to investigate the development of baby-friendly intervention of the infants through non-invasive stress monitoring. In mature neonates, urinary biopyrin concentration increased after birth along with the physiological increase of serum bilirubin levels. On the other hand, unexpected increase of biopyrin was observed in extreme premature infants, suggesting the intense physical stress exposed during the perinatal period.

Research Products

• [Journal Article] Human heme oxygenase-1deficiency presenting with hemolysis, nephritis and asplenia (2011)
  • Author(s): Radhakrishnan N, Yadav SP, SachdevaA, Pruthi PK, Sawhney S, Piplani T, WadaT, Yachie A
  • Journal Title: J PediatrHematol/Oncol Volume: 33 Pages: 74-78
  • Peer Reviewed
• [Journal Article] Urinary heme oxygenase-1 as a sensitive indicator of tubulointerstitial inflammatory damage in various renal diseases (2011)
  • Author(s): Yokoyama T, et al
  • Journal Title: Am J Nephrol Volume: 33 Pages: 414-420
  • Peer Reviewed
• [Journal Article] Human heme oxygenase-1 deficiency presenting with hemolysis, nephritis, and asplenia. (2011)
  • Author(s): Radhakrishnan N, et al
  • Journal Title: J Pediatr Hematol Oncol. Volume: 33 Pages: 74-78
  • Peer Reviewed
• [Journal Article] Distinct cytokine profiles of systemic-onset juvenile, idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 ini ts pathogenesis (2010)
  • Author(s): Shimizu M, Yokoyama T, Yamada K, Kaneda H, Wada H, Wada T, Toma T, OhtaK, Kasahara Y, Yachie A
  • Journal Title: Rheumatology Volume: 49 Pages: 1645-1653
  • Peer Reviewed
• [Journal Article] Distinct cytokine profiles of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of lnterleukin-18 in its pathogenesis. (2010)
  • Author(s): Shimizu M, et al.
  • Journal Title: J Rheumato] Volume: 49 Pages: 1645-1653
  • Peer Reviewed
• [Journal Article] Distinct cytokine profiles of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of Interleukin-18 in its pathogenesis (2010)
  • Author(s): Shimizu M, et al.
  • Journal Title: J Rheumatol (in press)
  • Peer Reviewed
• [Journal Article] Curcumin-induced modulationof inflammatory cytokine production bycirculating mononuclear cells via hemeoxygenase-1 (2009)
  • Author(s): Futaki T, Ei K, Shigeki O, Hiroshi N, Yachie A
  • Journal Title: 金沢大学つるま保健学会雑誌 Volume: 33 Pages: 11-19
  • Peer Reviewed
• [Journal Article] ヘモオキシナーゲ. 1(HO-1)による血管内皮細胞上の組織因子、トロンボモジュリンの調節 (2009)
  • Author(s): 丸山慶子、森下英理子、關谷暁子、長屋聡美、角野忠昭、朝倉英策、中尾眞二、大竹茂樹、谷内江昭宏
  • Journal Title: 日本血栓止血学会誌 Volume: 20 Pages: 316-322
  • Peer Reviewed
• [Journal Article] Curcumin-induced modulation of inflammatory cytokine production by circulating mononuclear cells via heme oxygenase-l (2009)
  • Author(s): Futagi T, et al.
  • Journal Title: J Tsuruma Health Science Society KU 33 Pages: 11-19
  • Peer Reviewed
• [Presentation] Urinary heme oxygenase-1 is a novelbiomarker for an inflammatory tubulointerstitialdamage in acute kidney injury (2010)
  • Author(s): Yokoyama T, Ohta K, Shimizu M, YachieA
  • Organizer: 15^<th> Congress of the International Pediatric Nephrology Association
  • Place of Presentation: New York
  • Year and Date: 2010-09-29
• [Presentation] HO-1欠損と無脾症;第2例目のHO-1欠損症とその病態 (2009)
  • Author(s): 谷内江昭宏、和田泰三、清水正樹、横山忠史、東馬智子、Radhakrishnan N、SachdevaA
  • Organizer: 第6回Heme Oxygenase研究フォーラム
  • Place of Presentation: Kyoto
  • Year and Date: 2009-08-28
• [Presentation] The diagnostic significance ofinterleukin-18 in patients with systemicjuvenile idiopathic arthritispredisposing to macrophage activationsyndrome (2009)
  • Author(s): Shimizu M, Yokoyama T, Kaneda H, WadaT, Toma T, Ohta K, Kasahara Y, Yachie A
  • Organizer: The 9^<th> World Congress on Inflammation
  • Place of Presentation: Tokyo