Sphingolipid Metabolism in Pregnancy and Fetal Development

• Project/Area Number: 21591414
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kyoto University (2011); Musashino University (2009-2010)
• Principal Investigator: MIZUGISHI Kiyomi 京都大学, 医学研究科, 研究員 (70518448)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 胎児医学 / スフィンゴ脂質 / 妊娠 / 胎児発育

Research Abstract

Sphingolipid metabolism is critical for the maintenance of normal pregnancy. Disturbance in sphingolipid metabolism causes early pregnancy loss. In this study, I elucidated the mechanism of pregnancy loss using sphingosine kinase-deficient female mice. The CXCL1 levels were markedly increased in the Sphk1^<-/->Sphk2^<+/-> decidua, where considerable amounts of neutrophils infiltrated, leading to embryonic death. These results suggest that sphingosine kinases might play a central role in conferring immune tolerance on the semiallogeneic embryo-fetal transplant by suppressing excessive inflammation in normal pregnancy.

Research Products

• [Journal Article] S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species (2010)
  • Author(s): Takuwa N, Ohkura S, Takashima S, Ohtani K, Okamoto Y, Tanaka T, Hirano K, Usui S, Wang F, Du W, Yoshioka K, Banno Y, Sasaki M, Ichi I, Okamura M, Sugimoto N, Mizugishi K, Nakanuma Y, Ishii I, Takamura M, Kaneko S, Kojo S, Satouchi K, Mitumori K, Chun J, Takuwa Y
  • Journal Title: Cardiovasc Res Volume: 85(3) Issue: 3 Pages: 484-493
  • DOI: 10.1093/cvr/cvp312
  • NAID: 120001939472
  • Peer Reviewed
• [Journal Article] The role of endothelial interleukin-8/NADPH oxidase 1 axis in sepsis. (2010)
  • Author(s): Miyoshi Takashi, Yamashita Kouhei, Arai Toshiyuki, Yamamoto Kokichi, Mizugishi Kiyomi, Uchiyama T akashi
  • Journal Title: Immunology Volume: 131 Issue: 3 Pages: 331-339
  • DOI: 10.1111/j.1365-2567.2010.03303.x
  • Peer Reviewed
• [Journal Article] The role of endothelial Interleukin-8/NADPH oxidase 1 axis in sepsis. (2010)
  • Author(s): 三好隆史
  • Journal Title: Immunology Volume: 131巻 Pages: 331-339
  • Peer Reviewed
• [Journal Article] S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species. (2010)
  • Author(s): 多久和典子
  • Journal Title: Cardiovascular Research 85巻 Pages: 484-493
  • Peer Reviewed