Effects of exercise during pregnancy on brain development and learning and emotional behavior in adult offspring and its mechanism
| Project/Area Number |
21591416
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Yamaguchi University |
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Principal Investigator |
NAKAMURA Shoji 山口大学, 大学院・医学系研究科, 教授 (80112051)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIKAWA Junko 山口大学, 大学院・医学系研究科, 助教 (30570808)
ISHIKAWA Akinori 山口大学, 大学院・医学系研究科, 准教授 (40363098)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 妊娠 / 運動 / ストレス / 学習 / 情動 / 海馬 / 八方向放射状迷路学習 / 空間学習 / 妊娠中の運動 / 妊娠中のストレス / 情動の発達 / 脳の発達 |
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| Research Abstract |
Effects of exercise during pregnancy on learning and emotional behavior in adult offspring were examined. Pregnant rats were allowed to perform spontaneous running in wheel cage during pregnancy. Learning and emotional behaviors were assessed at 7 to 15 weeks after birth. In addition, using DNA microarray analysis technique, genes affected by exercise during pregnancy were examined. Adult offspring whose dams performed spontaneous running during pregnancy showed increased depression-lile behavior and reduced levels of learning performance. DNA microarray analysis showed that exercise during pregnancy induced a large decrease in brain-derived neurotrophic factor(BDNF) in the hippocampus of adult offspring. These results suggest that spontaneous running during pregnancy causes impairment of learning and emotional behavior, possibly due to reduction in BDNF expression in the hippocampus.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Proteomic analysis of proteins expressing in regions of rat brain by a combination of SDS-PAGE with nano-liquid chromatography-quadrupole-time of flight tandem mass spectrometry2010
Author(s)
T. Katagiri, N. Hatano, M. Aihara, H. Kawano, M. Okamoto, Y. Liu, T. Izumi, T. Maekawa, S. Nakamura, T. Ishihara, M. Shirai, Y. Mizukami
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Journal Title
Proteome Science
Volume: 8
Pages: 41-52
Related Report
Peer Reviewed
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