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Development of Ductus Arteriosus Regulation Targeting Adenylyl Cyclases without Side Effect

Research Project

Project/Area Number 21591418
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionYokohama City University

Principal Investigator

IWASAKI Shiho  横浜市立大学, 医学部, 准教授 (10347338)

Co-Investigator(Renkei-kenkyūsha) YOKOYAMA Utako  横浜市立大学, 医学部, 講師 (70404994)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords動脈管 / アデニル酸シクラーゼ
Research Abstract

Prostaglandin E induces vasodilation and intimal thickening(IT) in the ductus arteriosus via activation of adenylyl cyclases(AC). We revealed that AC6 is responsible for hyaluronan production and AC2 inhibited it. Stimulation of both AC2 and AC6 by FD1 induced longer vasodilation without IT. FD1 may be a novel alternative therapy to currently available PGE therapy for ductus arteriosus.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (28 results)

All 2012 2011 2010 2009

All Journal Article (10 results) (of which Peer Reviewed: 8 results) Presentation (18 results)

  • [Journal Article] Immune responseto Haemophilus influenzae type b conjugate vaccine in preterm infants2012

    • Author(s)
      Tsuda K, Iwasaki S, Horiguchi H, Mori M, Nishimaki S, Seki K, Taguri M, Yokota S, Ishiwada N
    • Journal Title

      Pediatr Int

      Volume: 54(1) Pages: 64-7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Urinaryβ2-microglobulin in very preterm neonates with chorioamnionitis2011

    • Author(s)
      Nishimaki S, Shima Y, Sato M, An H, Fujita S, Iwasaki S, Horiguchi H, Seki K, Yokota S
    • Journal Title

      Pediatri Nephrol

      Volume: 26(12) Pages: 2185-91

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early discharge from a neonatal intensive care unit and rates of readmission2011

    • Author(s)
      Seki K, Iwasaki S, An H, Horiguchi H, Mori M, Nishimaki S, Yokota S
    • Journal Title

      Pediatr Int

      Volume: 53(1) Issue: 1 Pages: 7-12

    • DOI

      10.1111/j.1442-200x.2010.03179.x

    • NAID

      10029556906

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus2010

    • Author(s)
      Yokoyama U, Minamisawa S, Katayama A, Tang T, Suzuki S, Iwatsubo K, Iwasaki S, Kurotani R, Okumura S, Sato M, Yokota S, Hammond HK, Ishikawa Y
    • Journal Title

      Circ Res

      Volume: 106(12) Issue: 12 Pages: 1882-1892

    • DOI

      10.1161/circresaha.109.214924

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of vascular tone and remodeling of the ductus arteriosus2010

    • Author(s)
      Yokoyama U, Minamisawa S, Ishikawa Y
    • Journal Title

      J. Smooth Muscle Res

      Volume: 46(2) Pages: 77-87

    • NAID

      10030687229

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus2010

    • Author(s)
      岩崎志穂
    • Journal Title

      Circ Res.

      Volume: 25 Pages: 1882-1892

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soluble tumor necrosis factor receptor-I in preterm infants with chorioamnionitis2009

    • Author(s)
      Sato M, Nishimaki S, An H, Shima Y, Naruto T, Sugai T, Iwasaki S, Seki K, Imagawa T, Mori M, Yokota S
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 35(2) Pages: 252-7

    • NAID

      10025339217

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] たとえで簡単新生児呼吸器疾患とそのケア、呼吸急迫症候群2009

    • Author(s)
      岩崎志穂
    • Journal Title

      Neonatal care

      Volume: 22 Pages: 1238-1243

    • Related Report
      2011 Final Research Report
  • [Journal Article] T-type Ca2+channels promote oxygenation-induced closure of the rat ductus arteriosus not only by vasoconstriction but also by neointima formation2009

    • Author(s)
      Akaike T, Jin MH, Yokoyama U, Izumi-Nakaseko H, Jiao Q, Iwasaki S, Iwamoto M, Nishimaki S, Sato M, Yokota S, Kamiya Y, Adachi-Akahane S, Ishikawa Y, Minamisawa S
    • Journal Title

      J Biol Chem

      Volume: 284(36) Issue: 36 Pages: 24025-24034

    • DOI

      10.1074/jbc.m109.017061

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【たとえでかんたん 新生児呼吸器疾患とそのケア】呼吸窮迫症候群2009

    • Author(s)
      岩崎志穂
    • Journal Title

      Neonatal Care 22巻

      Pages: 1238-1243

    • Related Report
      2009 Annual Research Report
  • [Presentation] Oxygenation-induced postnatal remodeling of the ductus arteriosus2012

    • Author(s)
      Jin MH, Yokoyama U, Ishiwata R, Minamisawa S, IshikawaY
    • Organizer
      The 89^<th> Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      松本文化体育館,長野
    • Year and Date
      2012-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Inhibition of Phophodiesterase Type 3 Milrinone Dilate the Ductus Arteriosus without Forming Intimal Thickening2012

    • Author(s)
      Ichikawa Y, Yokoyama U, Ishikawa Y
    • Organizer
      The 89^<th> Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      松本文化体育館,長野
    • Year and Date
      2012-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Inhibition of EP4 Signaling Attenuates Mouse Aortic Aneurysm Formation2012

    • Author(s)
      Yokoyama U, Jin MH, Kato Y, Ishiwata R, Suzuki S, Masuda M, Asou T, Aoki H, Sugimoto Y, Nakamura T, Minamisawa S, Ishikawa Y
    • Organizer
      The 76^<rd> Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡国際会議場,福岡
    • Year and Date
      2012-03-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 動脈管収縮における出生後の血清浸透圧低下の役割2011

    • Author(s)
      青木理加, 横山詩子, 岩崎志穂, 関和男, 西巻滋, 横田俊平, 石川義弘
    • Organizer
      第56回日本未熟児新生児学会学術集会
    • Place of Presentation
      東京国際フォーラム,東京
    • Year and Date
      2011-11-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Regulation of vascular remodeling of the ductus arteriosus2011

    • Author(s)
      Yokoyama U, Minamisawa S, Ishikawa Y
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      パシフィコ横浜,神奈川
    • Year and Date
      2011-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Prostaglandin EP4 Signaling Negatively Regulates Vascular Elastic Fiber Assembly2010

    • Author(s)
      Yokoyama U, Shioda A, Kato Y, Asou T, Aoki H, Nakamura T, Minamisawa S, Ishikawa Y
    • Organizer
      The 84th Scientific Session, American Heart Association(AHA)
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2010-11-16
    • Related Report
      2011 Final Research Report
  • [Presentation] ラット動脈管閉鎖における低浸透圧センサーTransient Receptor Potential Melastatin3(TRPM3)チャネルの役割2010

    • Author(s)
      青木理加, 横山詩子, 岩崎志穂, 西巻滋, 横田俊平, 石川義弘
    • Organizer
      第55回未熟児新生児学会・学術集会
    • Place of Presentation
      神戸国際会議場,兵庫
    • Year and Date
      2010-11-07
    • Related Report
      2011 Final Research Report
  • [Presentation] ラット動脈管内膜肥厚におけるアデニル酸シクラーゼアイソフォームの役割の検討2010

    • Author(s)
      岩崎志穂
    • Organizer
      第46回日本周産期・新生児医学会
    • Place of Presentation
      神戸・神戸国際会議場
    • Year and Date
      2010-07-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A2010

    • Author(s)
      横山詩子
    • Organizer
      第52回日本平滑筋学会総会栗山煕賞受賞記念講演
    • Place of Presentation
      仙台市情報プラザアエル,宮城
    • Year and Date
      2010-07-01
    • Related Report
      2011 Final Research Report
  • [Presentation] ラット動脈管内膜肥厚におけるアデニル酸シクラーゼアイソフォームの役割の検討2010

    • Author(s)
      岩崎志穂, 青木理加, 西巻滋, 横田俊平, 南沢享, 横山詩子
    • Organizer
      第46回日本周産新生児医学会
    • Place of Presentation
      神戸国際会議場,兵庫
    • Related Report
      2011 Final Research Report
  • [Presentation] A Role of Thromboxane A2 Receptor in the Rat Ductus Arteriosus as a Vasoconstrictor2010

    • Author(s)
      Yokota T, Ozawa M, Yokoyama U, Minamisawa S
    • Organizer
      The 16th International Vascular Biology Meeting
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Counteracting regulation of vascular remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus2010

    • Author(s)
      Minamisawa S, Yokoyama U, Akaike T, Hammond K, Ishikawa Y
    • Organizer
      The 16^<th> International Vascular Biology Meeting
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Oxygenation Promotes Migration of Smooth Muscle Cell in the Rat Ductus Arteriosus2010

    • Author(s)
      Minamisawa S, Akaike T, Yokoyama U, Iwasaki S, Ishikawa Y
    • Organizer
      Developmental Vascular Biology Workshop IV
    • Place of Presentation
      Monterey, California
    • Related Report
      2011 Final Research Report
  • [Presentation] Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus2010

    • Author(s)
      Yokoyama U, Minamisawa S, Katayama A, Tang T, Iwasaki S, Hammond HK, Ishikawa Y
    • Organizer
      Developmental Vascular Biology Workshop IV
    • Place of Presentation
      Monterey, California
    • Related Report
      2011 Final Research Report
  • [Presentation] プロスタグランジンの予期せぬ役割Molecular Mechanisms of Closure of Dactus Arteriosus : Unexpected roles of prostaglandins2009

    • Author(s)
      南沢享, 横山詩子
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Related Report
      2011 Final Research Report
  • [Presentation] 胎生後期ラット動脈管におけるTRPMチャネルの発現~大動脈組織との比較検討~2009

    • Author(s)
      青木理加, 横山詩子, 岩崎志穂, 西巻滋, 横田俊平, 石川義弘
    • Organizer
      第54回日本未熟児新生児学会・学術集会
    • Place of Presentation
      パシフィコ横浜,神奈川
    • Related Report
      2011 Final Research Report
  • [Presentation] プロスタグランディンE受容体EP4シグナルによる弾性線維形成の制御2009

    • Author(s)
      横山詩子, 南沢享, 片山綾子, 塩田亜樹, 中邨智之, 杉本幸彦, 石川義弘
    • Organizer
      第13回Molecular Cardiovascular Conference
    • Place of Presentation
      北海道
    • Related Report
      2011 Final Research Report
  • [Presentation] Oxygenation Promotes Smooth Muscle Cell Migration in the Rat Ductus Arteriosus2009

    • Author(s)
      Minamisawa S, Akaike T, Yokoyama U, Ozawa M, Iwasaki S, Ishikawa I
    • Organizer
      BCVS Conference-Molecular Mechanisms of Cardiovascular Diseases
    • Place of Presentation
      Lake Las Vegas, Nevada
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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