The role of mTOR pathway in kidney development disorder induced by fetal programming.
| Project/Area Number |
21591420
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Embryonic/Neonatal medicine
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
HIDA Mariko 慶應義塾大学, 医学部, 共同研究員 (20276306)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
AWAZU Midori 慶應義塾大学, 医学部, 講師 (20129315)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | 胎児医学 / autophagy / エピジェネテイクス / oligonephronia / 子宮内発育遅滞 / ステロイド / 低栄養 / 成人病胎児期発症説(Barker仮説) / 腎発生 |
|---|
| Research Abstract |
The main purpose of this study is to elucidate the role of mTOR(The mammalian target of rapamycin) in developmental disorder of kidney induced by fetal programming. Maternal nutrient restriction(NR) or dexamethasone treatment(DEX) led to significant growth restriction and reduction of nephron number in fetal metanephros. Micro array of these metanephros revealed the NR and DEX had led to change in expression pattern of a large number of genes and proteins including mTOR pathways. Immunoblot and immunohistochemistry of metanephros, mTOR pathway was downregulated by NR and DEX. We are now analyzing the methylation pattern of some of the genes which expression alteration was detected in the micro array analysis. In conclusion, we have identified downregulation of mTOR pathway by NR or DEX, but the precise mechanism to be elucidated which may be important in the pathogenesis of fetal programming in kidney development.
|
Report
(4 results)
Research Products
(46 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] 日本人小児(2～12歳)のGFR推算式 中間報告2010
Author(s)
永井琢人, 上村治, 本田雅敬, 松山健, 秋岡祐子, 粟津緑, 飯島一誠, 池住洋平, 石倉健司, 伊藤秀一, 北山博嗣, 佐古まゆみ, 関根孝司, 幡谷浩史, 藤田直也, 矢田菜穂子, 山田拓司
-
Journal Title
日本小児腎臓病学会雑誌
Volume: 23
Pages: 245-249
Related Report
Peer Reviewed
-
[Journal Article] 日本人小児の血清クレアチニン基準値2010
Author(s)
上村治, 本田雅敬, 松山健, 秋岡祐子, 粟津緑, 飯島一誠, 池住洋平, 石倉健司, 伊藤秀一, 北山博嗣, 佐古まゆみ, 関根孝司, 永井琢人, 幡谷浩史, 藤田直也, 矢田菜穂子, 山田拓司
-
Journal Title
日本小児腎臓病学会雑誌
Volume: 23
Pages: 241-244
Related Report
Peer Reviewed
-
[Journal Article] 小児慢性腎臓病の薬物療法実態調査2010
Author(s)
矢田菜穂子, 上村治, 本田雅敬, 松山健, 秋岡祐子, 粟津緑, 飯島一誠, 池住洋平, 石倉健司, 伊藤秀一, 北山浩嗣, 佐古まゆみ, 関根孝司, 永井琢人, 幡谷浩史, 藤田直也, 山田拓司
-
Journal Title
日本小児科学会雑誌
Volume: 114
Pages: 1631-1635
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
