| Project/Area Number |
21591423
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Akane 東海大学, 医学部, 講師 (00384884)
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| Research Collaborator |
JAFFE Robert b. カリフォルニア大学サンフランシスコ校, 医学部, 教授
MUENCH Marcus O. カリフォルニア大学サンフランシスコ校, 医学部, 客員准教授
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 羊膜 / 胎児 / 副腎 / 羊水 / コルチゾール / ミッドカイン / 妊娠維持 / 胎児副腎 / アンギオテンシン変換酵素 |
|---|
| Research Abstract |
Our results demonstrate that factors that mediate the steroid-producing machinery in the outer zone of the human fetal adrenal gland(HFA), show zonal and/or ontogenic expression patterns relevant to the in vivo occurrence of cortisol and aldosterone synthesis at the periphery of the HFA in late gestation. Results also show that midkine, a heparin-binding growth factor, is likely secreted from the fetal lung into the amniotic fluid, and can suppress amniotic production of prostaglandin E2via COX2down-regulation, indicative of its role as a fetal signal for maintaining pregnancy.
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