| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Research Abstract |
Prenatal under-nutrition involves changes in the epigenetic regulation of specific genes. We investigated the effects of feeding pregnant rats a magnesium(Mg)-deficient diet on the methylation of cytosine-guanine(CpG) dinucleotides in hepatic glucocorticoid genes of neonatal offspring, compared with the controls. Mean methylation of the 11ss-hydroxysteroid dehydrogenase-2(Hsd11b2) promoter in the Mg-deficient offspring was higher than in controls. Ppara and Nr3c1 methylation status and expression did not differ between the groups. Therefore, a Mg-deficient diet alters glucocorticoid metabolism, predicting higher hepatic intracellular glucocorticoid concentrations, and is possibly a key mechanism that induces the metabolic complications of Mg deficiency.
|
