Impact of magnesium on epigenetics
| Project/Area Number |
21591424
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kansai Medical University |
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Principal Investigator |
TAKAYA Junji 関西医科大学, 医学部, 講師 (80247923)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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|---|
| Keywords | 胎児医学 / 遺伝子 / 環境 / 生理学 / 病理学 |
|---|
| Research Abstract |
Prenatal under-nutrition involves changes in the epigenetic regulation of specific genes. We investigated the effects of feeding pregnant rats a magnesium(Mg)-deficient diet on the methylation of cytosine-guanine(CpG) dinucleotides in hepatic glucocorticoid genes of neonatal offspring, compared with the controls. Mean methylation of the 11ss-hydroxysteroid dehydrogenase-2(Hsd11b2) promoter in the Mg-deficient offspring was higher than in controls. Ppara and Nr3c1 methylation status and expression did not differ between the groups. Therefore, a Mg-deficient diet alters glucocorticoid metabolism, predicting higher hepatic intracellular glucocorticoid concentrations, and is possibly a key mechanism that induces the metabolic complications of Mg deficiency.
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Report
(4 results)
Research Products
(13 results)
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[Presentation]2012
Organizer
第9回日本小児栄養研究会
Place of Presentation
西宮
Year and Date
2012-03-10
Related Report
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[Presentation]2010
Organizer
第30回日本マグネシウム学会学術集会
Place of Presentation
神戸
Year and Date
2010-11-20
Related Report
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