| Project/Area Number |
21591425
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
DEGUCHI Kimiko 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第二部, 研究生 (50227542)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Ken 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第二部, 室長 (30392418)
KUBO Kenichirou 慶應義塾大学, 医学部, 助教 (20348791)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 未熟児医学 / 神経幹細胞 / 高次脳機能障害 / 神経科学 / 脳神経疾患 / 動物モデル / 脳・神経 / 病理学 |
|---|
| Research Abstract |
Recently, higher brain dysfunction including hyperactivity and learning disability have been highlighted as neurological outcome of the extremely preterm infants. We hypothesized that the brain ischemia in the extremely preterm infants may result in injuries to the neurons migrating to cortex, subsequently damaging the developing cerebral cortex and causing higher brain dysfunction. In this study, we sought to establish a mouse model for prenatal ischemic brain injuries and delineated the cellular pathological basis for the higher brain dysfunction in extremely preterm infants.
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