Study on mechanism of dermatitis due to epidermal barrier disruption : analysis of model mouse with epidermis devoid of ceramide

• Project/Area Number: 21591436
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kochi University
• Principal Investigator: SANO Shigetoshi 高知大学, 教育研究部・医療学系, 教授 (80273621)
• Co-Investigator(Kenkyū-buntansha): NAKAJIMA Kimiko 高知大学, 教育研究部・医療学系, 講師 (20403892) ; YAMAMOTO Mayuko 高知大学, 教育研究部・医療学系, 助教 (20423478)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 皮膚病理学 / 乾癬 / 表皮セラミド / IL-17 / IL-23 / 表皮バリア / Th17 / γδT細胞 / アトピー性皮膚炎 / TSLP / 表皮バリア破綻 / Th2

Research Abstract

Here, we generated Sptlc2 targeted mice under control of the keratin 5 promoter(referred to as K5-SPT-KO mice), by which their keratinocytes were devoid of SPT. These mice demonstrated lower water-holding capacity and barrier dysfunction. From 2 weeks of age, they developed skin inflammation, showing psoriasis-like histopathologic changes. K5-SPT-KO mice showed increased numbers ofγδ-T cells that produced IL-17(γδ-17) in the skin lesion and lymph nodes and most of them also produced IL-22, similar to Th17 cells. In vivo administration of anti-IL-12/ 23p40 antibody ameliorated the skin lesions and reducedγδ-17 cells in K5-SPT-KO mice. Therefore, we conclude that ceramide deficiency in the epidermis results in the development of psoriasis-like lesions.

Research Products

• [Journal Article] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model (2011)
  • Author(s): Nakajima K, Kanda T, Takaishi M, Shiga T, Miyoshi K, Nakajima H, Kamijima R, Tarutani M, Benson JM, Elloso MM, Gutshall LL, Naso MF, Iwakura Y, DiGiovanni J, Sano S
  • Journal Title: J Immunol Volume: 186 Pages: 4481-4489
  • Peer Reviewed
• [Journal Article] Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients (2011)
  • Author(s): Nakajima H, Nakajima K, Tarutani M, Morishige R, Sano S
  • Journal Title: Arch Dermatol Res Volume: 303 Pages: 451-455
  • Peer Reviewed
• [Journal Article] Stat3 as a therapeutic target for the treatment of psoriasis. A clinical feasibility study with STA-21, a Stat3 Inhibitor (2011)
  • Author(s): Miyoshi K, Takaishi M, Nakajima K, Ikeda M, Kanda T, Tarutani M, Iiyama T, Asao N, Digiovanni J, Sano S
  • Journal Title: J Invest Dermatol Volume: 131 Pages: 108-117
  • Peer Reviewed
• [Journal Article] 炎症性角化症尋常性乾癬病態と治療の進歩 (2011)
  • Author(s): 佐野栄紀
  • Journal Title: 日皮会誌 Volume: 121 Pages: 839-44
  • Peer Reviewed
• [Journal Article] Th17細胞と乾癬 (2011)
  • Author(s): 佐野栄紀
  • Journal Title: アレルギーの臨 Volume: 31 Pages: 197-201
  • Peer Reviewed
• [Journal Article] 序乾癬:新たなパラダイム (2011)
  • Author(s): 佐野栄紀
  • Journal Title: アレルギー免疫 Volume: 18 Pages: 9-11
  • Peer Reviewed
• [Journal Article] Th17と乾癬 (2011)
  • Author(s): 中島喜美子、佐野栄紀
  • Journal Title: アレルギー免疫 Volume: 18 Pages: 33-38
  • Peer Reviewed
• [Journal Article] 乾癬の発症機序 (2011)
  • Author(s): 佐野栄紀
  • Journal Title: 綜合臨 Volume: 60 Pages: 2325-2326
  • Peer Reviewed
• [Journal Article] Stat3 as a therapeutic target for the treatment of psoriasis. A clinical feasibility study with STA-21, a Stat3 Inhibitor (2011)
  • Author(s): Miyoshi K, Takaishi M, Nakajima K, Ikeda M, Kanda T, Tarutani M, Iiyama T, Asao N, Digiovanni J, Sano S
  • Journal Title: Journal of Investigative Dermatology Volume: 131 Pages: 108-117
  • Peer Reviewed
• [Journal Article] Diminished regulatory T cells in cutaneous lesions of thymoma-associated multi-organ autoimmunity : A newly described paraneoplastic autoimmune disorder with fatal clinical course (2011)
  • Author(s): Hanafusa T, Azukizawa H, Kitaba S, Murota H, Umegaki N, Terao M, Sano S, Nakagiri T, Okumura M, Katayama I
  • Journal Title: Clinical & Experimental Immunology Volume: 164 Pages: 164-170
  • Peer Reviewed
• [Journal Article] 18FDG PET/CT is a powerful tool for detecting subclinical arthritis in patients with psoriatic arthritis and/or psoriasis vulgaris (2011)
  • Author(s): Takata T, Taniguchi Y, Ohnishi T, Kohsaki S, Nogami M, Nakajima H, Kumon Y, Terada Y, Ogawa Y,Tarutani M, Sano S
  • Journal Title: Journal of Dermatological Science Volume: 64 Pages: 144-147
  • NAID: 10030893406
  • Peer Reviewed
• [Journal Article] Safety and effectiveness of a new enzyme-targeting radiosensitization treatment (KORTUC II) for intratumoral injection for low-LET radioresistant tumors (2011)
  • Author(s): Ogawa Y, Kubota K, Ue H, Tadokoro M, Matsui R, Yamanishi T, Hamada N, Kariya S, Nishioka A, Nakajima H, Tarutani M, Sano S
  • Journal Title: International Journal of Oncology Volume: 39 Pages: 553-560
  • Peer Reviewed
• [Journal Article] Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients (2011)
  • Author(s): Nakajima H, Nakajima K, Tarutani M, Morishige R, Sano S
  • Journal Title: Archives of Dermatological Research Volume: 303 Pages: 451-455
  • Peer Reviewed
• [Journal Article] Altered lipid profiles in the stratum comeum of Sjogren-Larsson Syndrome (2011)
  • Author(s): Nakajima K, Sano S, Uchida Y, Akiyama M, Morita Y, Shimizu H
  • Journal Title: Journal of Dermatological Science Volume: 303 Pages: 451-455
  • Peer Reviewed
• [Journal Article] Presence of Merkel cell polyomavirus in Japanese cutaneous squamous cell carcinoma (2011)
  • Author(s): Murakami M, Imajoh M, Ikawa T, Nakajima H, Kamioka M, Nemoto Y, Ujihara T, Uchiyama J, Matsuzaki S, Sano S, Daibata M
  • Journal Title: Journal of Clinical Virology Volume: 50 Pages: 37-41
  • Peer Reviewed
• [Journal Article] Ramsay-Hunt syndrome (2011)
  • Author(s): Taguchi T, Ueda S, Kudo T, Nakajima H, Nishioka R, Sano S, Terada Y
  • Journal Title: Journal of Infection Volume: 62 Pages: 180-181
  • Peer Reviewed
• [Journal Article] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model (2011)
  • Author(s): Nakajima K, Kanda T, Takaishi M, Shiga T, Miyoshi K, Nakajima H, Kamijima R, Tarutani M, Benson JM, Elloso MM, Gutshall LL, Naso MF, Iwakura Y, DiGiovanni J, Sano S
  • Journal Title: Journal of Immunology Volume: 186 Pages: 4481-4489
  • Peer Reviewed
• [Journal Article] Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis (2011)
  • Author(s): Swindell WR, Johnston A, Carbajal S, Han G, Wohn C, Lu J, Xing X, Nair RP, Voorhees JJ, Elder JT, Wang XJ, Sano S, Prens EP, Digiovanni J, Pittelkow MR, Ward NL, Gudjonsson JE
  • Journal Title: PLosOne Volume: 6;e18266 Pages: 1-20
  • Peer Reviewed
• [Journal Article] Distinct Roles of IL-23 and IL-17 in the Development of Psoriasis-Like Lesions in a Mouse Model. (2011)
  • Author(s): Nakajima K, Kanda T, Takaishi M, Shiga T, Miyoshi K, Nakajima H, Kamijima R, Tarutani M, Benson JM, Elloso MM, Gutshall LL, Naso MF, Iwakura Y, Digiovanni J, Sano S.
  • Journal Title: J Immunol Volume: 186 Pages: 4481-4489
  • Peer Reviewed
• [Journal Article] Stat3 as a therapeutic target for the treatment of psoriasis : a clinical feasibility study with STA-21, a Stat3 inhibitor. (2011)
  • Author(s): Miyoshi K, Takaishi M, Nakajima K, Ikeda M, Kanda T, Tarutani M, Iiyama T, Asao N, DiGiovanni J, Sano S.
  • Journal Title: J Invest Dermatol Volume: 131 Pages: 108-117
  • Peer Reviewed
• [Journal Article] Presence of Merkel cell polyomavirus in Japanese cutaneous squamous cell carcinoma. (2011)
  • Author(s): Murakami M, Imajoh M, Ikawa T, Nakajima H, Kamioka M, Nemoto Y, Ujihara T, Uchiyama J, Matsuzaki S, Sano S, Daibata M.
  • Journal Title: J Clin Virol Volume: 50 Pages: 37-41
  • Peer Reviewed
• [Journal Article] Altered lipid profiles in the stratum corneum of Sjogren-Larsson Syndrome. (2011)
  • Author(s): Kimiko Nakajima, Yoshikazu Uchida; Masashi Akiyama; Yukari Morita; Hiroshi Shimizu; Shigetoshi Sano.
  • Journal Title: J Dermatol Sci Volume: (in press)
  • NAID: 10030891977
  • Peer Reviewed
• [Journal Article] 序～乾癬:新たなパラダイム～ (2011)
  • Author(s): 佐野栄紀
  • Journal Title: 免疫・アレルギー Volume: 18 Pages: 9-11
  • Peer Reviewed
• [Journal Article] XI.乾癬モデル動物を用いた研究と新たな治療法 (2011)
  • Author(s): 佐野栄紀
  • Journal Title: 免疫・アレルギー Volume: 18 Pages: 88-94
  • Peer Reviewed
• [Journal Article] Th17細胞と乾癬 (2011)
  • Author(s): 佐野栄紀
  • Journal Title: アレルギーの臨床 Volume: 31 Pages: 17-21
  • Peer Reviewed
• [Journal Article] 表皮とStat3もろ刃の剣としてのマスターシグナル (2010)
  • Author(s): 佐野栄紀
  • Journal Title: 医のあゆみ Volume: 234 Pages: 578-583
  • Peer Reviewed
• [Journal Article] 表皮角化細胞のStat3シグナル(前編) (2010)
  • Author(s): 佐野栄紀
  • Journal Title: 西日皮膚 Volume: 72 Pages: 54-59
  • NAID: 10026322038
  • Peer Reviewed
• [Journal Article] 表皮角化細胞のStat3シグナル(中編) (2010)
  • Author(s): 佐野栄紀
  • Journal Title: 西日皮膚 Volume: 72 Pages: 145-151
  • NAID: 10026322225
  • Peer Reviewed
• [Journal Article] 表皮角化細胞のStat3シグナル(後編) (2010)
  • Author(s): 佐野栄紀
  • Journal Title: 西日皮膚 Volume: 72 Pages: 229-234
  • NAID: 130004475366
  • Peer Reviewed
• [Journal Article] Circulating level of chemerin is upregulated in psoriasis. (2010)
  • Author(s): Nakajima H, Nakajima K, Nagano Y, Yamamoto M, Tarutani M, Takahashi M, Takahashi Y, Sano S.
  • Journal Title: J Dermatol Sci Volume: 60 Pages: 45-47
  • NAID: 10027473682
  • Peer Reviewed
• [Journal Article] High prevalence of coinfection with mucosal high-risk type HPV(HR-HPV)and cutaneous HR-HPV in Bowen's disease in the fingers. (2010)
  • Author(s): Nakajima H, Teraishi M, Tarutani M, Sano S.
  • Journal Title: J Dermatol Sci Volume: 60 Pages: 50-52
  • NAID: 10027473700
  • Peer Reviewed
• [Journal Article] 表皮角化細胞のStat3シグナル(後編) (2010)
  • Author(s): 佐野栄紀
  • Journal Title: 西日本皮膚科 Volume: 72 Pages: 229-234
  • NAID: 130004475366
  • Peer Reviewed
• [Journal Article] 表皮とStat3-もろ刃の剣としてのマスターシグナル- (2010)
  • Author(s): 佐野栄紀
  • Journal Title: 医学のあゆみ Volume: 234 Pages: 578-583
  • Peer Reviewed
• [Journal Article] 関節症性乾癬とその成因(解説) (2010)
  • Author(s): 佐野栄紀
  • Journal Title: 皮膚病診療 Volume: 32 Pages: 1160-1165
  • Peer Reviewed
• [Journal Article] Favorable response of reticular erythematous mucinosis to UVB irradiationusing a 308-nm excimer lamp (2010)
  • Author(s): Miyoshi, K.Miyajima, O.Yokogawa, M.Sano, S.
  • Journal Title: The Journal of Dermatology 37 Pages: 163-166
  • Peer Reviewed
• [Journal Article] 表皮角化細胞の Stat3 シグナル(前編) (2010)
  • Author(s): 佐野栄紀
  • Journal Title: 西日本皮膚科 1119 Pages: 54-59
  • NAID: 10026322038
  • Peer Reviewed
• [Journal Article] 表皮角化細胞の Stat3 シグナル(中編) (2010)
  • Author(s): 佐野栄紀
  • Journal Title: 西日本皮膚科 72 Pages: 145-151
  • NAID: 10026322225
  • Peer Reviewed
• [Journal Article] 乾癬発症のメカニズム (2009)
  • Author(s): 佐野栄紀
  • Journal Title: 皮の科 Volume: 8 Pages: 800-804
  • NAID: 130004547415
  • Peer Reviewed
• [Journal Article] 新しい治療法Stat3阻害剤の臨床応用 (2009)
  • Author(s): 佐野栄紀, 横川真紀, 三好研
  • Journal Title: 日皮会誌 Volume: 19 Pages: 2883-2885
  • Peer Reviewed
• [Journal Article] Constitutive activation and targeted disruption of signal transducer and activator of transcription 3(Stat3) in mouse epidermis reveal its critical role in UVB-induced skin carcinogenesis (2009)
  • Author(s): Kim DJ, Angel JM, Sano S, DiGiovanni J
  • Journal Title: Oncogene Volume: 28 Pages: 950-960
  • Peer Reviewed
• [Journal Article] Constitutive activation and targeted disruption of signal transducer and activator of transcription 3(Stat3)in mouse epidermis reveal its critical role in UVB-induced skin carcinogenesis (2009)
  • Author(s): Kim, D.J.Angel, J.M.Sano, S.DiGiovanni, J.
  • Journal Title: Oncogene 28 Pages: 950-960
  • Peer Reviewed
• [Journal Article] Screening of the specific polyoma virus as diagnostic and prognostic tools for Merkel cell carcinoma (2009)
  • Author(s): Nakajima, H.Takaishi, M.Yamamoto, M.Kamijima, R.Kodama, H.Tarutani, M.Sano, S.
  • Journal Title: Journal of Dermatological Science 56 Pages: 210-212
  • NAID: 10027398958
  • Peer Reviewed
• [Journal Article] 新しい治療法 Stat3 阻害剤の臨床応用 (2009)
  • Author(s): 佐野栄紀
  • Journal Title: 日本皮膚科学会雑誌 119 Pages: 2883-2885
  • Peer Reviewed
• [Journal Article] 乾癬発症のメカニズム (2009)
  • Author(s): 佐野栄紀
  • Journal Title: 皮膚の科学 8 Pages: 800-804
  • NAID: 130004547415
  • Peer Reviewed
• [Presentation] Induction of mesenchymal-epithelial transition in fibroblast-like spindle cancer cells by reprogramming factors (2011)
  • Author(s): Takaishi M, Takeda J, Sano S
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-12-13
• [Presentation] Development of psoriasis-like lesions in a mouse model by IL-23-dependent but IL-22-independent signaling (2011)
  • Author(s): Takaishi M, Nakajima K, Ouyang W, Sano S
  • Organizer: The 36^<th> annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 京都
  • Year and Date: 2011-12-09
• [Presentation] Inhibitory effect of a cathepsin K inhibitor on the development of psoriasis-like lesions (2011)
  • Author(s): Hirai T, Kanda T, Nakajima K, Yamamoto M, Sano S
  • Organizer: The 36^<th> annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 京都
  • Year and Date: 2011-12-09
• [Presentation] Epicutaneous treatment with TLR7 agonist leads to lupus glomerulonephritis in wild-type mice (2011)
  • Author(s): Sano S, Yokogawa M, Takaishi M, Nakajima K, Kataoka S
  • Organizer: The 36^<th> annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 京都
  • Year and Date: 2011-12-09
• [Presentation] Epicutaneous treatment with TLR7 agonist leads to lupus glomerulonephritis in wild-type mice (2011)
  • Author(s): Sano S, Yokogawa M, Takaishi M, Nakajima K, Kataoka S
  • Organizer: The 36th annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-12-09
• [Presentation] Novel imaging mass spectrometry to visualize essential epidermal barrier ceramides required for mammalian survival (2011)
  • Author(s): Uchida Y, Goto-Inoue N, Hayasaka T, Zaima N, Nakajima K, Sano S, Holleran WM, Setou M
  • Organizer: The 36th annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-12-09
• [Presentation] Inhibitory effect of a cathepsin K inhibitor on the development of psoriasis-like lesions (2011)
  • Author(s): Hirai T, Kanda T, Nakajima K, Yamamoto M, Sano S
  • Organizer: The 36th annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-12-09
• [Presentation] Development of psoriasis-like lesions in a mouse model by IL-23-dependent but IL-22-independent signaling (2011)
  • Author(s): Takaishi M, Nakajima K, Ouyang W, Sano S
  • Organizer: The 36th annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-12-09
• [Presentation] Psoriasis-like skin lesion induced by Raf-MAPK signaling requires Stat3 activation (2011)
  • Author(s): Tarutani M, Miyoshi K, Takaishi M, Sano S
  • Organizer: The 36th annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-12-09
• [Presentation] Anti-tumor effect of imiquimod on UVB-induced SCC is mediated through Th1/Th17 cells (2011)
  • Author(s): Yokogawa M, Shiga T, Nakajima K, Takaishi M, Tarutani M, DiGiovanni J, Sano S
  • Organizer: The 36th annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-12-09
• [Presentation] Topical tacrolimus treatment does not facilitate UV-induced carcinogenesis in a mouse model (2011)
  • Author(s): Shiga T, Kawamura K, Kamijima R, Yokogawa M, Tarutani M, Sano S
  • Organizer: The 36th annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-12-09
• [Presentation] Sebaceous glands as the primary target of EGFR-inhibitor in the development of papulopustular eruption (2011)
  • Author(s): Takata T, Tarutani M, Sano S
  • Organizer: The 36th annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-12-09
• [Presentation] T cell subcet of tumor-infiltrating lymphocytes predict prognosis of patients with cutaneous angiosarcoma (2011)
  • Author(s): Fujii H, Arakawa A, Kitoh A, Matsumura T, Konishi K, Sano S, Miyachi Y, Tanioka M
  • Organizer: The 36th annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-12-09
• [Presentation] A novel link between Th17 cutokines and adipokines in psoriasis (2011)
  • Author(s): Nakajima H, Nakajima K, Tarutani M, Morishige R, Sano S
  • Organizer: The 36th annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-12-09
• [Presentation] 乾癬・関節症性乾癬の病態・治療の最新話題 (2011)
  • Author(s): 佐野栄紀
  • Organizer: 日本脊椎関節炎学会,第21回学術集会ランチョンセミナー
  • Place of Presentation: 岡山
  • Year and Date: 2011-09-17
• [Presentation] 乾癬発症のためのサイトカインヒエラルキー (2011)
  • Author(s): 佐野栄紀
  • Organizer: 第26回日本乾癬学会学術大会ランチョンセミナー
  • Place of Presentation: 大阪
  • Year and Date: 2011-09-09
• [Presentation] 表皮特異的セラミドノックアウトマウスの皮膚バリア異常のイメージング (2011)
  • Author(s): 中島喜美子、佐野栄紀
  • Organizer: 第43回日本臨床分子形態学会総会・学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2011-09-09
• [Presentation] IL-23 is essential, but IL-22 is dispensable for the development of psoriasis-like lesions in K5.Stat3C mice (2011)
  • Author(s): Takaishi M, Nakajima K, Wenjun Ouyang, Sano S
  • Organizer: 41st Annual ESDR Meeting
  • Place of Presentation: Barcelona International Convention Centre (Spain)
  • Year and Date: 2011-09-07
• [Presentation] Inhibitory Effect of a Cathepsin K Inhibitor on the Development of Psoriasis-Like Lesions in a Mouse Model (2011)
  • Author(s): Hirai T, Kanda T, Nakajima K, Yamamoto M, Sano S
  • Organizer: 41st Annual ESDR Meeting
  • Place of Presentation: Barcelona International Convention Centre (Spain)
  • Year and Date: 2011-09-07
• [Presentation] Increased expression of endothelin-1 in cultured keratinocyte by combined treatments with narrow-band ultraviolet B irradation and tacalcitol (2011)
  • Author(s): Takata T, Tarutani M, Sano S
  • Organizer: 22nd World Congress of Dermatology
  • Place of Presentation: COEX Convention and Exhibition Center (Seoul, Korea)
  • Year and Date: 2011-05-24
• [Presentation] A case of nevoid basal cell carcinomasyndrome (2011)
  • Author(s): Kudo T, Shiga T, Nakajima H, Tarutani M, Sano S
  • Organizer: 22nd World Congress of Dermatology
  • Place of Presentation: COEX Convention and Exhibition Center (Seoul, Korea)
  • Year and Date: 2011-05-24
• [Presentation] Pityriasis rubra pilaris treated with maxacalcitol and narrow-band uvbirradiation (2011)
  • Author(s): Okino T, Kitagawa C, Nakajima H, Tarutani M, Sano S
  • Organizer: 22nd World Congress of Dermatology
  • Place of Presentation: COEX Convention and Exhibition Center (Seoul, Korea)
  • Year and Date: 2011-05-24
• [Presentation] Mouse Model for Psoriatic Arthritis (2011)
  • Author(s): Sano S
  • Organizer: 22nd World Congress of Dermatology
  • Place of Presentation: COEX Convention and Exhibition Center (Seoul, Korea)(招待講演)
  • Year and Date: 2011-05-24
• [Presentation] Reprogramming genes for induced pluripotent stem cells (iPSCs) reversed changes. associated with epithelial-to-mesenchymal transition of skin cancer cells (2011)
  • Author(s): Takaishi M, Yamamoto M, Yokogawa M, Takeda J, Sano S
  • Organizer: The 71th Annual Meeting of the Society for Investigative Dermatology
  • Place of Presentation: JW Marriott Desert Ridge Resort and Spa (Phenix, U.S.A)
  • Year and Date: 2011-05-04
• [Presentation] Psoriasis-like skin lesion induced by Raf-MAPK signaling requires Stat3 activation (2011)
  • Author(s): Tarutani M, Miyoshi K, Takaishi M, Sano S
  • Organizer: The 71th Annual Meeting of the Society for Investigative Dermatology
  • Place of Presentation: JW Marriott Desert Ridge Resort and Spa (Phenix, U.S.A)
  • Year and Date: 2011-05-04
• [Presentation] Primary ceramide deficiency in keratinocytes leads to gene alterations linked to dermatitis (2011)
  • Author(s): Nakajima K, Terao M, Azukizawa H, Katayama I, Takeda J, Sano S
  • Organizer: The 71th Annual Meeting of the Society for Investigative Dermatology
  • Place of Presentation: JW Marriott Desert Ridge Resort and Spa (Phenix, U.S.A)
  • Year and Date: 2011-05-04
• [Presentation] Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis (2011)
  • Author(s): Swindell WR, Johnston A, Carbajal S, Han G, Wohn C, Lu J, Xing X, Nair R P, Voorhees J J, Elder JT, Wang X-J, Sano S, Prens EP, DiGiovanni J, Pittelkow MR, Ward NL, Gudjonsson JE
  • Organizer: The 71th Annual Meeting of the Society for Investigative Dermatology
  • Place of Presentation: JW Marriott Desert Ridge Resort and Spa (Phenix, U.S.A)
  • Year and Date: 2011-05-04
• [Presentation] Cytokine aberrations in a mouse model of psoriatic arthritis (2011)
  • Author(s): Yamamoto M, Sano S
  • Organizer: The 71th Annual Meeting of the Society for Investigative Dermatology
  • Place of Presentation: JW Marriott Desert Ridge Resort and Spa (Phenix, U.S.A)
  • Year and Date: 2011-05-04
• [Presentation] Topical tacrolimus treatment does not facilitate UV-induced carcinogenesis in a mouse model (2011)
  • Author(s): Shiga T, Yokogawa M, Tarutani M, Sano S
  • Organizer: The 71th Annual Meeting of the Society for Investigative Dermatology
  • Place of Presentation: JW Marriott Desert Ridge Resort and Spa (Phenix, U.S.A)
  • Year and Date: 2011-05-04
• [Presentation] 乾癬研究・治療の新たな展開 (2011)
  • Author(s): 佐野栄紀
  • Organizer: 日本皮膚科学会第121回山陰・第17回島根合同地方会ランチョンセミナー
  • Place of Presentation: 出雲
  • Year and Date: 2011-03-13
• [Presentation] 乾癬研究・治療の新たな展開 (2011)
  • Author(s): 佐野栄紀
  • Organizer: 日本皮膚科学会第121回山陰・第17回島根合同地方会
  • Place of Presentation: ニューウェルシティ出雲(島根)
  • Year and Date: 2011-03-13
• [Presentation] A novel link between Th 17 cutokines and adipokines in psoriasis (2011)
  • Author(s): Nakajima H, Nakajima K, Tarutani M, Morishige R, Sano S.
  • Organizer: The 36^<th> annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 京都
• [Presentation] Anti-tumor effect of imiquimod on UVB-induced SCC is mediated through Th1/ Th17 cells (2011)
  • Author(s): Yokogawa M, Shiga T, Nakajima K, Takaishi M, Tarutani M, DiGiovanni J, Sano S
  • Organizer: The 36^<th> annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 京都
• [Presentation] Mouse Model for Psoriatic Arthritis (2011)
  • Author(s): Sano S
  • Organizer: 22nd World Congress of Dermatology KDA Seminar
  • Place of Presentation: Seoul
• [Presentation] Cytokine aberrations in a mouse model of psoriatic arthritis (2011)
  • Author(s): Yamamoto M, Sano S
  • Organizer: The 71th Annual Meeting of the Society for Investigative Dermatology
  • Place of Presentation: Phenix, U. S. A
• [Presentation] Psoriasis-like skin lesion induced by Raf-MAPK signaling requires Stat3 activation (2011)
  • Author(s): Tarutani M, Miyoshi K, Takaishi M, Sano S
  • Organizer: The 71th Annual Meeting of the Society for Investigative Dermatology
  • Place of Presentation: Phenix, U. S. A
• [Presentation] Primary ceramide deficiency in keratinocytes leads to gene alterations linked to dermatitis (2011)
  • Author(s): Nakajima K, Terao M, Azukizawa H, Katayama I, Takeda J, Sano S
  • Organizer: The 71th Annual Meeting of the Society for Investigative Dermatology
  • Place of Presentation: Phenix, U. S. A
• [Presentation] Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis (2011)
  • Author(s): Swindell WR, Johnston A, Carbajal S, Han G, Wohn C, Lu J, Xing X, Nair R P, Voorhees J J, Elder JT, Wang X-J, Sano S, Prens EP, DiGiovanni J, Pittelkow MR, Ward NL, Gudjonsson JE.
  • Organizer: The 71th Annual Meeting of the Society for Investigative Dermatology
  • Place of Presentation: Phenix, U. S. A
• [Presentation] 乾癬の発症に関わるリンフォカインネットワーク (2010)
  • Author(s): 佐野栄紀
  • Organizer: 第74回日本皮膚科学会東部支部学術大会ランチョンセミナー
  • Place of Presentation: 仙台
  • Year and Date: 2010-11-21
• [Presentation] 乾癬の発症に関わるリンフォカインネットワーク (2010)
  • Author(s): 佐野栄紀
  • Organizer: 第74回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 江陽グランドホテル(仙台)
  • Year and Date: 2010-11-20
• [Presentation] 表皮バリアと炎症 (2010)
  • Author(s): 佐野栄紀
  • Organizer: 第62回日本皮膚科学会西部支部学術大会
  • Place of Presentation: 倉敷市芸文館倉敷市立美術館(岡山)
  • Year and Date: 2010-10-23
• [Presentation] K5.Stat3C transgenic mouse as a model of psoriasis. (2010)
  • Author(s): S.Sano
  • Organizer: The First Eastern Asia Dermatology Congress
  • Place of Presentation: Hotel New Otani Hakata.(福岡)
  • Year and Date: 2010-09-30
• [Presentation] 乾癬モデルマウス(K5. Stat3C transgenic mice)におけるIL23/ Th17 axisについて (2010)
  • Author(s): 中島喜美子,佐野栄紀
  • Organizer: 第25回日本乾癬学会学術大会
  • Place of Presentation: 宇部
  • Year and Date: 2010-09-03
• [Presentation] Merkel細胞癌とポリオーマウイルス (2010)
  • Author(s): 佐野栄紀
  • Organizer: 第37回皮膚かたち研究学会学術大会
  • Place of Presentation: 石垣記念ホール(東京)
  • Year and Date: 2010-07-25
• [Presentation] マウスモデルで明らかになった乾癬におけるIL23/ Th17径路の役割 (2010)
  • Author(s): 佐野栄紀
  • Organizer: 第109回日本皮膚科学会総会ランチョンセミナー
  • Place of Presentation: 大阪
  • Year and Date: 2010-04-17
• [Presentation] マウスモデルで明らかになった乾癬におけるIL23/Th17径路の役割 (2010)
  • Author(s): 佐野栄紀
  • Organizer: 第109回日本皮膚科学会総会
  • Place of Presentation: 大阪国際会議場(グランキューブ大阪)リーガロイヤルホテル大阪堂島リバーフォーラム(大阪)
  • Year and Date: 2010-04-17
• [Presentation] 皮膚疾患モデル動物の未来 (2010)
  • Author(s): 佐野栄紀,堀江恭二,竹田潤二
  • Organizer: 第109回日本皮膚科学会総会特別企画「未来皮膚科学」
  • Place of Presentation: 大阪
  • Year and Date: 2010-04-16
• [Presentation] 皮膚疾患モデル動物の未来 (2010)
  • Author(s): 佐野栄紀
  • Organizer: 第109回日本皮膚科学会総会
  • Place of Presentation: 大阪国際会議場(グランキューブ大阪)リーガロイヤルホテル大阪堂島リバーフォーラム(大阪)
  • Year and Date: 2010-04-16
• [Presentation] Recent progress in psoriasis research on mechanistic interaction between cytokines and keratinocytes : A distinct role of the IL-23/ Th17 axis (2010)
  • Author(s): Sano S
  • Organizer: The 20^<th> academic meeting of KoreanSociety for Investigative Dermatology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-04-02
• [Presentation] Recent progress in psoriasis research on mechanistic interaction between cytokines and keratinocytes : a distinct role of the IL-23/Th17 axis (2010)
  • Author(s): S.Sano
  • Organizer: The Korean Society for Investigative Dermatology
  • Place of Presentation: Clinical Research Institute Seoul National University Hospital(韓国)
  • Year and Date: 2010-04-02
• [Presentation] Recent progress in psoriasis research on mechanistic interaction between cytokinesand keratinocytes (2009)
  • Author(s): Sano S
  • Organizer: 第34回日本研究皮膚科学会学術大会・総会ランチョンセミナー
  • Place of Presentation: 福岡
  • Year and Date: 2009-12-05
• [Presentation] Recent progress in psoriasis research on mechanistic interaction between cytokines and keratinocytes (2009)
  • Author(s): 佐野栄紀
  • Organizer: 日本研究皮膚科学会第34回年次学術大会・総会
  • Place of Presentation: JALリゾートシーホークホテル(福岡)
  • Year and Date: 2009-12-05
• [Presentation] Skin barrier disruption results in alteration of cutaneous immuneresponses (2009)
  • Author(s): Nakajima, K.Takaishi, M.Terao, M.Azukizawa, H.Katayama, I.Takeda, J.Sano, S.
  • Organizer: 日本研究皮膚科学会第34回年次学術大会・総会
  • Place of Presentation: JALリゾートシーホークホテル(福岡)
  • Year and Date: 2009-12-04
• [Presentation] 活性型ビタミンD3が持つ乾癬以外の多様な疾患に対する効果 (2009)
  • Author(s): 佐野栄紀
  • Organizer: 第61回日本皮膚科学会東部支部学術大会モーニングセミナー
  • Place of Presentation: 甲府
  • Year and Date: 2009-09-27
• [Presentation] 活性型ビタミンD3が持つ乾癬以外の多様な疾患に対する効果 (2009)
  • Author(s): 佐野栄紀
  • Organizer: 第73回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 甲府富士屋ホテル(甲府)
  • Year and Date: 2009-09-26
• [Presentation] 乾癬の発症機序 (2009)
  • Author(s): 佐野栄紀
  • Organizer: 第125回日本皮膚科学会広島地方会-第25回 矢村記念講演-
  • Place of Presentation: 広島国際会議場(広島)
  • Year and Date: 2009-09-13
• [Presentation] Ceramide deficiency in epidermis results in development of drmatitis through Langerhans cell maturation and expasion of IL-17-producing gd T cells (2009)
  • Author(s): 佐野栄紀
  • Organizer: 39th Annual ESDR Meeting
  • Place of Presentation: Semmelweis University(ブダペスト)ハンガリー
  • Year and Date: 2009-09-09
• [Presentation] 乾癬とTh17 (2009)
  • Author(s): 佐野栄紀
  • Organizer: 第24回日本乾癬学会
  • Place of Presentation: 東海大学校友会館(東京)
  • Year and Date: 2009-09-05
• [Presentation] 乾癬とTh17 (2009)
  • Author(s): 佐野栄紀
  • Organizer: 第24回日本乾癬学会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-04
• [Presentation] 日光角化症の発症におけるStat3の役割および特異的Stat3阻害軟膏による治療の試み:モデルマウスを用いた解析 (2009)
  • Author(s): 佐野栄紀
  • Organizer: 第5回加齢皮膚医学研究会
  • Place of Presentation: ホテル徳島東急イン(徳島)
  • Year and Date: 2009-07-12
• [Presentation] Impact of Stat3 on Skin Biology (2009)
  • Author(s): 佐野栄紀
  • Organizer: 2009 Gordon Conference on Epithelial Differentiation & Keratinization
  • Place of Presentation: Les Diablerets Conference Center(スイス)
  • Year and Date: 2009-06-21
• [Presentation] 近未来の乾癬治療 (2009)
  • Author(s): 佐野栄紀
  • Organizer: 第25回日本臨床皮膚科医会総会
  • Place of Presentation: 高知
  • Year and Date: 2009-05-10
• [Presentation] 近未来の乾癬治療 (2009)
  • Author(s): 佐野栄紀
  • Organizer: 第25回日本臨床皮膚科医会総会
  • Place of Presentation: 高知新阪急ホテル(高知)
  • Year and Date: 2009-05-09
• [Presentation] Stat3阻害剤の臨床応用 (2009)
  • Author(s): 佐野栄紀
  • Organizer: 第108回日本皮膚科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2009-04-24
• [Presentation] Stat3阻害剤の臨床応用 (2009)
  • Author(s): 佐野栄紀
  • Organizer: 第108回日本皮膚科学会総会
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 2009-04-24
• [Presentation] Ceramide deficiency in epidermis results in development of drmatitis through Langerhans cell maturation and expasion of IL-17-producing gd T cells (2009)
  • Author(s): Sano S, Nakajima K, Terao M, Takaishi M, Azukizawa H, Katayama I, Takeda J
  • Organizer: 39th Annual ESDR Meeting
  • Place of Presentation: Budapest, Hungary
• [Presentation] Impact of Stat3 on Skin Biology (2009)
  • Author(s): Sano S
  • Organizer: 2009 Gordon Conference on Epithelial Differentiation & Keratinization
  • Place of Presentation: Les Diablerets, Switzerland
• [Book] 今日の治療指針2010年版(魚鱗癬.飯塚一編) (2010)
  • Author(s): 佐野栄紀
  • Total Pages: 967
  • Publisher: 医学書院
• [Book] 今日の治療指針2010年版 (2010)
  • Author(s): 佐野栄紀
  • Total Pages: 967
  • Publisher: 株式会社 医学書院